{"cited_by_count":441960,"description":"This cluster of papers focuses on the molecular mechanisms, pathophysiological consequences, and clinical management of Hereditary Angioedema. It covers topics such as the role of kinin receptors, coagulation factors XII and XI, polyphosphate, C1 inhibitor deficiency, and the use of bradykinin-receptor antagonists in the treatment of angioedema. Additionally, it explores the involvement of tissue kallikreins and the contact activation system in the disease pathology.","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11917","wikipedia":"https://en.wikipedia.org/wiki/Hereditary_angioedema"},"field_id":"27","id":"T11917","keywords":[{"display_name":"bradykinin","id":"bradykinin","score":0.3351,"url":"https://openalex.org/keywords/bradykinin"},{"display_name":"hereditary angioedema","id":"hereditary-angioedema","score":0.8304,"url":"https://openalex.org/keywords/hereditary-angioedema"},{"display_name":"kallikrein-kinin system","id":"kallikrein-kinin-system","score":0.6107,"url":"https://openalex.org/keywords/kallikrein-kinin-system"},{"display_name":"C1 inhibitor deficiency","id":"c1-inhibitor-deficiency","score":0.8909,"url":"https://openalex.org/keywords/c1-inhibitor-deficiency"},{"display_name":"angioedema","id":"angioedema","score":0.2418,"url":"https://openalex.org/keywords/angioedema"},{"display_name":"C1 inhibitor","id":"c1-inhibitor","score":0.5234,"url":"https://openalex.org/keywords/c1-inhibitor"},{"display_name":"kallikrein","id":"kallikrein","score":0.4908,"url":"https://openalex.org/keywords/kallikrein"},{"display_name":"bradykinin B2 receptor","id":"bradykinin-b2-receptor","score":0.4851,"url":"https://openalex.org/keywords/bradykinin-b2-receptor"},{"display_name":"factor XII","id":"factor-xii","score":0.5416,"url":"https://openalex.org/keywords/factor-xii"},{"display_name":"kinins","id":"kinins","score":0.5179,"url":"https://openalex.org/keywords/kinins"},{"display_name":"high molecular weight kininogen","id":"high-molecular-weight-kininogen","score":0.7475,"url":"https://openalex.org/keywords/high-molecular-weight-kininogen"},{"display_name":"prekallikrein","id":"prekallikrein","score":0.7385,"url":"https://openalex.org/keywords/prekallikrein"},{"display_name":"kininogen","id":"kininogen","score":0.6859,"url":"https://openalex.org/keywords/kininogen"},{"display_name":"plasma kallikrein","id":"plasma-kallikrein","score":0.6922,"url":"https://openalex.org/keywords/plasma-kallikrein"},{"display_name":"icatibant","id":"icatibant","score":0.7352,"url":"https://openalex.org/keywords/icatibant"},{"display_name":"factor XI","id":"factor-xi","score":0.3796,"url":"https://openalex.org/keywords/factor-xi"},{"display_name":"bradykinin receptor antagonists","id":"bradykinin-receptor-antagonists","score":0.6382,"url":"https://openalex.org/keywords/bradykinin-receptor-antagonists"},{"display_name":"contact activation","id":"contact-system-activation","score":0.4806,"url":"https://openalex.org/keywords/contact-system-activation"},{"display_name":"bradykinin B1 receptor","id":"bradykinin-b1-receptor","score":0.6168,"url":"https://openalex.org/keywords/bradykinin-b1-receptor"},{"display_name":"drug-induced angioedema","id":"drug-induced-angioedema","score":0.8361,"url":"https://openalex.org/keywords/drug-induced-angioedema"},{"display_name":"bradykinin receptors","id":"bradykinin-receptors","score":0.5263,"url":"https://openalex.org/keywords/bradykinin-receptors"},{"display_name":"acquired angioedema","id":"acquired-angioedema","score":0.8435,"url":"https://openalex.org/keywords/acquired-angioedema"},{"display_name":"tissue kallikrein","id":"tissue-kallikrein","score":0.5706,"url":"https://openalex.org/keywords/tissue-kallikrein"},{"display_name":"des-Arg9-bradykinin","id":"des-arg9-bradykinin","score":0.7122,"url":"https://openalex.org/keywords/des-arg9-bradykinin"},{"display_name":"factor XI deficiency","id":"factor-xi-deficiency","score":0.2755,"url":"https://openalex.org/keywords/factor-xi-deficiency"}],"legacy_keywords":["Hereditary Angioedema","Kinin Receptor Family","Coagulation Factor XII","Polyphosphate","C1 Inhibitor Deficiency","Bradykinin-Receptor Antagonist","Factor XI Antisense Oligonucleotide","Tissue Kallikreins","Contact Activation System","Thrombosis"],"openalex_id":"https://openalex.org/T11917","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2716","url":"/topics/T11917","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11917","works_count":29944,"label":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","provider":"openalex","revision":"7bbcddb1fd877a6b","taxonomy_revision":"f050b5d4780b1289","title":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249527199919402","address_version":"morton4x16-v1","coordinates":[4,27,2716,11917],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}