{"cited_by_count":294250,"description":"This cluster of papers focuses on the classification, diagnosis, and treatment of histiocytic disorders, including Langerhans Cell Histiocytosis and Erdheim-Chester Disease. It explores the role of BRAF mutations, immunohistochemical approaches to classification, and consensus guidelines for clinical management. The papers also delve into the pathogenesis, molecular characterization, and therapy intensification for multisystem involvement.","display_name":"Histiocytic Disorders and Treatments","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11909","wikipedia":"https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis"},"field_id":"27","id":"T11909","keywords":[{"display_name":"Langerhans cell histiocytosis","id":"langerhans-cell-histiocytosis","score":0.8152,"url":"https://openalex.org/keywords/langerhans-cell-histiocytosis"},{"display_name":"Rosai-Dorfman disease","id":"rosai-dorfman-disease","score":0.9269,"url":"https://openalex.org/keywords/rosai-dorfman-disease"},{"display_name":"Erdheim-Chester disease","id":"erdheim-chester-disease","score":0.8806,"url":"https://openalex.org/keywords/erdheim-chester-disease"},{"display_name":"histiocytosis","id":"histiocytosis","score":0.6458,"url":"https://openalex.org/keywords/histiocytosis"},{"display_name":"eosinophilic granuloma","id":"eosinophilic-granuloma","score":0.5494,"url":"https://openalex.org/keywords/eosinophilic-granuloma"},{"display_name":"non-Langerhans cell histiocytosis","id":"non-langerhans-cell-histiocytosis","score":0.9584,"url":"https://openalex.org/keywords/non-langerhans-cell-histiocytosis"},{"display_name":"juvenile xanthogranuloma","id":"juvenile-xanthogranuloma","score":0.8264,"url":"https://openalex.org/keywords/juvenile-xanthogranuloma"},{"display_name":"CD1a","id":"cd1a","score":0.3322,"url":"https://openalex.org/keywords/cd1a"},{"display_name":"histiocytic disorders","id":"histiocytic-disorders","score":0.8708,"url":"https://openalex.org/keywords/histiocytic-disorders"},{"display_name":"pulmonary Langerhans cell histiocytosis","id":"pulmonary-langerhans-cell-histiocytosis","score":0.7124,"url":"https://openalex.org/keywords/pulmonary-langerhans-cell-histiocytosis"},{"display_name":"adult-onset Langerhans cell histiocytosis","id":"adult-langerhans-cell-histiocytosis","score":0.9828,"url":"https://openalex.org/keywords/adult-langerhans-cell-histiocytosis"},{"display_name":"Hand-Sch\u00fcller-Christian disease","id":"hand-schuller-christian-disease","score":0.8994,"url":"https://openalex.org/keywords/hand-schuller-christian-disease"},{"display_name":"blastic plasmacytoid dendritic cell neoplasm","id":"blastic-plasmacytoid-dendritic-cell-neoplasm","score":0.4848,"url":"https://openalex.org/keywords/blastic-plasmacytoid-dendritic-cell-neoplasm"},{"display_name":"emperipolesis","id":"emperipolesis","score":0.6114,"url":"https://openalex.org/keywords/emperipolesis"},{"display_name":"Letterer-Siwe disease","id":"letterer-siwe-disease","score":0.8952,"url":"https://openalex.org/keywords/letterer-siwe-disease"},{"display_name":"histiocytic sarcoma","id":"histiocytic-sarcoma","score":0.4852,"url":"https://openalex.org/keywords/histiocytic-sarcoma"},{"display_name":"malignant histiocytosis","id":"malignant-histiocytosis","score":0.5755,"url":"https://openalex.org/keywords/malignant-histiocytosis"},{"display_name":"histiocytic neoplasms","id":"histiocytic-neoplasms","score":0.7909,"url":"https://openalex.org/keywords/histiocytic-neoplasms"},{"display_name":"multicentric reticulohistiocytosis","id":"multicentric-reticulohistiocytosis","score":0.8181,"url":"https://openalex.org/keywords/multicentric-reticulohistiocytosis"},{"display_name":"follicular dendritic cell sarcoma","id":"follicular-dendritic-cell-sarcoma","score":0.542,"url":"https://openalex.org/keywords/follicular-dendritic-cell-sarcoma"},{"display_name":"cutaneous Langerhans cell histiocytosis","id":"cutaneous-langerhans-cell-histiocytosis","score":0.966,"url":"https://openalex.org/keywords/cutaneous-langerhans-cell-histiocytosis"},{"display_name":"cutaneous histiocytosis","id":"cutaneous-histiocytosis","score":0.8555,"url":"https://openalex.org/keywords/cutaneous-histiocytosis"},{"display_name":"histiocytic proliferation","id":"histiocytic-proliferation","score":0.7111,"url":"https://openalex.org/keywords/histiocytic-proliferation"},{"display_name":"xanthogranuloma","id":"xanthogranuloma","score":0.4467,"url":"https://openalex.org/keywords/xanthogranuloma"},{"display_name":"Birbeck granules","id":"birbeck-granules","score":0.4358,"url":"https://openalex.org/keywords/birbeck-granules"}],"legacy_keywords":["Langerhans Cell Histiocytosis","Erdheim-Chester Disease","Dendritic Cell Neoplasms","BRAF Mutations","Clinical Management","Immunohistochemical Approach","Multisystem Involvement","Therapy Intensification","Pathogenesis","Molecular Characterization"],"openalex_id":"https://openalex.org/T11909","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2737","url":"/topics/T11909","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11909","works_count":33558,"label":"Histiocytic Disorders and Treatments","provider":"openalex","revision":"edb8b70774cfa7c2","taxonomy_revision":"f050b5d4780b1289","title":"Histiocytic Disorders and Treatments","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249527204063534","address_version":"morton4x16-v1","coordinates":[4,27,2737,11909],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}