{"cited_by_count":1426309,"description":"This cluster of papers focuses on the structural and functional aspects of protein binding specificity, particularly in human serum albumin. The research encompasses various techniques such as fluorescence spectroscopy, crystallographic analysis, and molecular docking to investigate drug interactions, antioxidant properties, fatty acid binding, and plasma protein binding. The studies provide insights into the molecular mechanisms underlying protein-ligand interactions and their implications for drug development and therapeutic potential.","display_name":"Protein Interaction Studies and Fluorescence Analysis","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11908","wikipedia":"https://en.wikipedia.org/wiki/Protein%E2%80%93ligand_interaction"},"field_id":"13","id":"T11908","keywords":[{"display_name":"human serum albumin","id":"human-serum-albumin","score":0.383,"url":"https://openalex.org/keywords/human-serum-albumin"},{"display_name":"binding constant","id":"binding-constant","score":0.216,"url":"https://openalex.org/keywords/binding-constant"},{"display_name":"binding sites","id":"binding-sites","score":0.2513,"url":"https://openalex.org/keywords/binding-sites"},{"display_name":"binding thermodynamics","id":"binding-thermodynamics","score":0.3396,"url":"https://openalex.org/keywords/binding-thermodynamics"},{"display_name":"drug-protein binding","id":"drug-protein-binding","score":0.7094,"url":"https://openalex.org/keywords/drug-protein-binding"},{"display_name":"static quenching","id":"static-quenching","score":0.5032,"url":"https://openalex.org/keywords/static-quenching"},{"display_name":"drug-protein interactions","id":"drug-protein-interactions","score":0.4211,"url":"https://openalex.org/keywords/drug-protein-interactions"},{"display_name":"drug-albumin binding","id":"drug-albumin-binding","score":0.8384,"url":"https://openalex.org/keywords/drug-albumin-binding"},{"display_name":"binding distance","id":"binding-distance","score":0.8088,"url":"https://openalex.org/keywords/binding-distance"},{"display_name":"equilibrium dialysis","id":"equilibrium-dialysis","score":0.2828,"url":"https://openalex.org/keywords/equilibrium-dialysis"},{"display_name":"drug binding sites","id":"drug-binding-sites","score":0.2032,"url":"https://openalex.org/keywords/drug-binding-sites"},{"display_name":"fatty acid binding","id":"fatty-acid-binding","score":0.3011,"url":"https://openalex.org/keywords/fatty-acid-binding"},{"display_name":"subdomain IIA","id":"subdomain-iia","score":0.9603,"url":"https://openalex.org/keywords/subdomain-iia"},{"display_name":"free drug fraction","id":"free-drug-fraction","score":0.3975,"url":"https://openalex.org/keywords/free-drug-fraction"},{"display_name":"dye-protein interaction","id":"protein-dye-interaction","score":0.4842,"url":"https://openalex.org/keywords/protein-dye-interaction"},{"display_name":"Sudlow site I","id":"sudlow-site-i","score":0.9205,"url":"https://openalex.org/keywords/sudlow-site-i"},{"display_name":"dye-protein binding","id":"protein-dye-binding","score":0.6004,"url":"https://openalex.org/keywords/protein-dye-binding"},{"display_name":"binding site I","id":"binding-site-i","score":0.936,"url":"https://openalex.org/keywords/binding-site-i"},{"display_name":"drug displacement","id":"drug-displacement","score":0.5051,"url":"https://openalex.org/keywords/drug-displacement"},{"display_name":"unbound fraction","id":"unbound-fraction","score":0.2374,"url":"https://openalex.org/keywords/unbound-fraction"},{"display_name":"Stern-Volmer constant","id":"stern-volmer-constant","score":0.2116,"url":"https://openalex.org/keywords/stern-volmer-constant"},{"display_name":"tryptophan microenvironment","id":"tryptophan-microenvironment","score":0.4354,"url":"https://openalex.org/keywords/tryptophan-microenvironment"},{"display_name":"intrinsic fluorescence quenching","id":"intrinsic-fluorescence-quenching","score":0.4423,"url":"https://openalex.org/keywords/intrinsic-fluorescence-quenching"},{"display_name":"tryptophan fluorescence quenching","id":"tryptophan-fluorescence-quenching","score":0.2151,"url":"https://openalex.org/keywords/tryptophan-fluorescence-quenching"},{"display_name":"metal-protein binding","id":"metal-protein-binding","score":0.3551,"url":"https://openalex.org/keywords/metal-protein-binding"}],"legacy_keywords":["Serum Albumin","Protein Binding","Fluorescence Spectroscopy","Drug Interaction","Crystal Structure Analysis","Molecular Docking","Plasma Protein Binding","Antioxidant Properties","Fatty Acid Binding","Biophysical Studies"],"openalex_id":"https://openalex.org/T11908","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T11908","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11908","works_count":40753,"label":"Protein Interaction Studies and Fluorescence Analysis","provider":"openalex","revision":"365ffc973447fe95","taxonomy_revision":"f050b5d4780b1289","title":"Protein Interaction Studies and Fluorescence Analysis","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36183297734224387","address_version":"morton4x16-v1","coordinates":[1,13,1312,11908],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}