{"cited_by_count":1694676,"description":"This cluster of papers focuses on the structure, function, and dysfunction of the blood-brain barrier, as well as the interactions between astrocytes, endothelial cells, and pericytes in the neurovascular unit. It covers topics such as tight junctions, CNS drug delivery, neurological diseases, and the role of various cell types in maintaining vascular homeostasis.","display_name":"Barrier Structure and Function Studies","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11872","wikipedia":"https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier"},"field_id":"28","id":"T11872","keywords":[{"display_name":"blood-brain barrier","id":"blood-brain-barrier","score":0.2544,"url":"https://openalex.org/keywords/blood-brain-barrier"},{"display_name":"tight junctions","id":"tight-junctions","score":0.2547,"url":"https://openalex.org/keywords/tight-junctions"},{"display_name":"blood-brain barrier permeability","id":"blood-brain-barrier-permeability","score":0.3321,"url":"https://openalex.org/keywords/blood-brain-barrier-permeability"},{"display_name":"blood-brain barrier disruption","id":"blood-brain-barrier-disruption","score":0.245,"url":"https://openalex.org/keywords/blood-brain-barrier-disruption"},{"display_name":"brain drug delivery","id":"drug-delivery-to-the-brain","score":0.2728,"url":"https://openalex.org/keywords/drug-delivery-to-the-brain"},{"display_name":"brain microvascular endothelial cells","id":"brain-microvascular-endothelial-cells","score":0.4382,"url":"https://openalex.org/keywords/brain-microvascular-endothelial-cells"},{"display_name":"pericytes","id":"pericytes","score":0.2144,"url":"https://openalex.org/keywords/pericytes"},{"display_name":"occludin","id":"occludin","score":0.2343,"url":"https://openalex.org/keywords/occludin"},{"display_name":"brain endothelial cells","id":"brain-endothelial-cells","score":0.4219,"url":"https://openalex.org/keywords/brain-endothelial-cells"},{"display_name":"ZO-1","id":"zo-1","score":0.206,"url":"https://openalex.org/keywords/zo-1"},{"display_name":"claudin-5","id":"claudin-5","score":0.5235,"url":"https://openalex.org/keywords/claudin-5"},{"display_name":"cerebral microvasculature","id":"cerebral-microvasculature","score":0.3157,"url":"https://openalex.org/keywords/cerebral-microvasculature"},{"display_name":"neurovascular unit","id":"neurovascular-unit","score":0.3435,"url":"https://openalex.org/keywords/neurovascular-unit"},{"display_name":"paracellular permeability","id":"paracellular-permeability","score":0.3613,"url":"https://openalex.org/keywords/paracellular-permeability"},{"display_name":"blood-CSF barrier","id":"blood-cerebrospinal-fluid-barrier","score":0.3205,"url":"https://openalex.org/keywords/blood-cerebrospinal-fluid-barrier"},{"display_name":"blood-brain barrier integrity","id":"blood-brain-barrier-integrity","score":0.3639,"url":"https://openalex.org/keywords/blood-brain-barrier-integrity"},{"display_name":"transendothelial electrical resistance","id":"transendothelial-electrical-resistance","score":0.5489,"url":"https://openalex.org/keywords/transendothelial-electrical-resistance"},{"display_name":"blood-brain barrier dysfunction","id":"blood-brain-barrier-dysfunction","score":0.3718,"url":"https://openalex.org/keywords/blood-brain-barrier-dysfunction"},{"display_name":"claudins","id":"claudins","score":0.3242,"url":"https://openalex.org/keywords/claudins"},{"display_name":"in vitro BBB model","id":"in-vitro-bbb-model","score":0.862,"url":"https://openalex.org/keywords/in-vitro-bbb-model"},{"display_name":"brain capillaries","id":"brain-capillaries","score":0.5317,"url":"https://openalex.org/keywords/brain-capillaries"},{"display_name":"endothelial junctions","id":"endothelial-junctions","score":0.2247,"url":"https://openalex.org/keywords/endothelial-junctions"},{"display_name":"claudin-2","id":"claudin-2","score":0.2211,"url":"https://openalex.org/keywords/claudin-2"},{"display_name":"brain endothelium","id":"brain-endothelium","score":0.4364,"url":"https://openalex.org/keywords/brain-endothelium"},{"display_name":"barrier permeability","id":"barrier-permeability","score":0.515,"url":"https://openalex.org/keywords/barrier-permeability"}],"legacy_keywords":["Blood-Brain Barrier","Neurovascular Unit","Tight Junctions","Pericytes","Endothelial Cells","Astrocyte Interactions","Barrier Dysfunction","CNS Drug Delivery","Neurological Diseases","Vascular Homeostasis"],"openalex_id":"https://openalex.org/T11872","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2808","url":"/topics/T11872","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11872","works_count":49567,"label":"Barrier Structure and Function Studies","provider":"openalex","revision":"208c89dfff508a26","taxonomy_revision":"f050b5d4780b1289","title":"Barrier Structure and Function Studies","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249525266309633","address_version":"morton4x16-v1","coordinates":[1,28,2808,11872],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}