{"cited_by_count":557170,"description":"This cluster of papers focuses on the management, diagnosis, and treatment of Primary Aldosteronism, a condition characterized by the overproduction of aldosterone by the adrenal glands. The research covers topics such as case detection, cardiovascular events, glucocorticoid and mineralocorticoid receptor actions, hypertension, and the use of spironolactone therapy. 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receptor","id":"mineralocorticoid-receptor","score":0.3645,"url":"https://openalex.org/keywords/mineralocorticoid-receptor"},{"display_name":"hyperaldosteronism","id":"hyperaldosteronism","score":0.5526,"url":"https://openalex.org/keywords/hyperaldosteronism"},{"display_name":"adrenal vein sampling","id":"adrenal-vein-sampling","score":0.7527,"url":"https://openalex.org/keywords/adrenal-vein-sampling"},{"display_name":"plasma aldosterone","id":"plasma-aldosterone-concentration","score":0.4156,"url":"https://openalex.org/keywords/plasma-aldosterone-concentration"},{"display_name":"secondary hypertension","id":"secondary-hypertension","score":0.2589,"url":"https://openalex.org/keywords/secondary-hypertension"},{"display_name":"aldosterone-renin ratio","id":"aldosterone-to-renin-ratio","score":0.8189,"url":"https://openalex.org/keywords/aldosterone-to-renin-ratio"},{"display_name":"aldosterone synthase","id":"aldosterone-synthase","score":0.6941,"url":"https://openalex.org/keywords/aldosterone-synthase"},{"display_name":"aldosterone secretion","id":"aldosterone-secretion","score":0.5218,"url":"https://openalex.org/keywords/aldosterone-secretion"},{"display_name":"CYP11B2","id":"cyp11b2","score":0.6399,"url":"https://openalex.org/keywords/cyp11b2"},{"display_name":"aldosterone biosynthesis","id":"aldosterone-biosynthesis","score":0.6496,"url":"https://openalex.org/keywords/aldosterone-biosynthesis"},{"display_name":"mineralocorticoids","id":"mineralocorticoids","score":0.289,"url":"https://openalex.org/keywords/mineralocorticoids"},{"display_name":"eplerenone","id":"eplerenone","score":0.308,"url":"https://openalex.org/keywords/eplerenone"},{"display_name":"11\u03b2-hydroxysteroid dehydrogenase type 2","id":"11beta-hydroxysteroid-dehydrogenase-type-2","score":0.3225,"url":"https://openalex.org/keywords/11beta-hydroxysteroid-dehydrogenase-type-2"},{"display_name":"zona glomerulosa","id":"zona-glomerulosa","score":0.3208,"url":"https://openalex.org/keywords/zona-glomerulosa"},{"display_name":"endocrine hypertension","id":"endocrine-hypertension","score":0.6922,"url":"https://openalex.org/keywords/endocrine-hypertension"},{"display_name":"bilateral adrenal hyperplasia","id":"bilateral-adrenal-hyperplasia","score":0.6091,"url":"https://openalex.org/keywords/bilateral-adrenal-hyperplasia"},{"display_name":"11\u03b2-hydroxysteroid dehydrogenase","id":"11beta-hydroxysteroid-dehydrogenase","score":0.3445,"url":"https://openalex.org/keywords/11beta-hydroxysteroid-dehydrogenase"},{"display_name":"mineralocorticoid excess","id":"mineralocorticoid-excess","score":0.538,"url":"https://openalex.org/keywords/mineralocorticoid-excess"},{"display_name":"glucocorticoid metabolism","id":"glucocorticoid-metabolism","score":0.2118,"url":"https://openalex.org/keywords/glucocorticoid-metabolism"},{"display_name":"idiopathic hyperaldosteronism","id":"idiopathic-hyperaldosteronism","score":0.9499,"url":"https://openalex.org/keywords/idiopathic-hyperaldosteronism"},{"display_name":"secondary hyperaldosteronism","id":"secondary-hyperaldosteronism","score":0.4687,"url":"https://openalex.org/keywords/secondary-hyperaldosteronism"}],"legacy_keywords":["Primary Aldosteronism","Aldosterone","Hypertension","Cardiovascular Events","Glucocorticoid","Mineralocorticoid Receptor","Adrenal Vein Sampling","Spironolactone Therapy","Metabolic Syndrome","Renal Injury"],"openalex_id":"https://openalex.org/T11839","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2712","url":"/topics/T11839","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11839","works_count":37780,"label":"Hormonal Regulation and Hypertension","provider":"openalex","revision":"948e370260071f49","taxonomy_revision":"f050b5d4780b1289","title":"Hormonal Regulation and 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