{"cited_by_count":608268,"description":"This cluster of papers focuses on the association between polyomaviruses, particularly Merkel cell polyomavirus and JC virus, with the development of malignancies such as Merkel cell carcinoma and the manifestation of progressive multifocal leukoencephalopathy in immunocompromised individuals. It also explores the impact of immunosuppressive therapies, viral replication in renal transplant recipients, and the potential role of viral oncoproteins in promoting tumorigenesis.","display_name":"Polyomavirus and related diseases","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11827","wikipedia":"https://en.wikipedia.org/wiki/Merkel_cell_polyomavirus"},"field_id":"27","id":"T11827","keywords":[{"display_name":"Merkel cell carcinoma","id":"merkel-cell-carcinoma","score":0.7229,"url":"https://openalex.org/keywords/merkel-cell-carcinoma"},{"display_name":"BK virus","id":"bk-polyomavirus","score":0.7265,"url":"https://openalex.org/keywords/bk-polyomavirus"},{"display_name":"progressive multifocal leukoencephalopathy","id":"progressive-multifocal-leukoencephalopathy","score":0.6429,"url":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy"},{"display_name":"JC virus","id":"jc-virus","score":0.7957,"url":"https://openalex.org/keywords/jc-virus"},{"display_name":"simian virus 40","id":"simian-virus-40","score":0.5661,"url":"https://openalex.org/keywords/simian-virus-40"},{"display_name":"polyomavirus","id":"polyomavirus","score":0.668,"url":"https://openalex.org/keywords/polyomavirus"},{"display_name":"Merkel cell polyomavirus","id":"merkel-cell-polyomavirus","score":0.8064,"url":"https://openalex.org/keywords/merkel-cell-polyomavirus"},{"display_name":"BK virus nephropathy","id":"bk-virus-nephropathy","score":0.7448,"url":"https://openalex.org/keywords/bk-virus-nephropathy"},{"display_name":"large T antigen","id":"large-t-antigen","score":0.7412,"url":"https://openalex.org/keywords/large-t-antigen"},{"display_name":"T antigen","id":"t-antigen","score":0.4118,"url":"https://openalex.org/keywords/t-antigen"},{"display_name":"small T antigen","id":"small-t-antigen","score":0.8187,"url":"https://openalex.org/keywords/small-t-antigen"},{"display_name":"BK viremia","id":"bk-virus-viremia","score":0.7272,"url":"https://openalex.org/keywords/bk-virus-viremia"},{"display_name":"human polyomaviruses","id":"human-polyomavirus","score":0.7007,"url":"https://openalex.org/keywords/human-polyomavirus"},{"display_name":"neuroendocrine skin cancer","id":"neuroendocrine-skin-cancer","score":0.9358,"url":"https://openalex.org/keywords/neuroendocrine-skin-cancer"},{"display_name":"BK virus reactivation","id":"bk-virus-reactivation","score":0.8027,"url":"https://openalex.org/keywords/bk-virus-reactivation"},{"display_name":"SV40 T antigen","id":"sv40-t-antigen","score":0.2515,"url":"https://openalex.org/keywords/sv40-t-antigen"},{"display_name":"polyomavirus-associated nephropathy","id":"polyomavirus-associated-nephropathy","score":0.7991,"url":"https://openalex.org/keywords/polyomavirus-associated-nephropathy"},{"display_name":"papovavirus","id":"papovavirus","score":0.536,"url":"https://openalex.org/keywords/papovavirus"},{"display_name":"BK virus infection","id":"bk-virus-infection","score":0.595,"url":"https://openalex.org/keywords/bk-virus-infection"},{"display_name":"neuroendocrine skin tumor","id":"neuroendocrine-skin-tumor","score":0.8623,"url":"https://openalex.org/keywords/neuroendocrine-skin-tumor"},{"display_name":"cutaneous neuroendocrine carcinoma","id":"cutaneous-neuroendocrine-carcinoma","score":0.8013,"url":"https://openalex.org/keywords/cutaneous-neuroendocrine-carcinoma"},{"display_name":"metastatic Merkel cell carcinoma","id":"metastatic-merkel-cell-carcinoma","score":0.8294,"url":"https://openalex.org/keywords/metastatic-merkel-cell-carcinoma"},{"display_name":"polyomavirus infection","id":"polyomavirus-infection","score":0.7125,"url":"https://openalex.org/keywords/polyomavirus-infection"},{"display_name":"BK viruria","id":"bk-viruria","score":0.8881,"url":"https://openalex.org/keywords/bk-viruria"},{"display_name":"JC virus reactivation","id":"jc-virus-reactivation","score":0.8517,"url":"https://openalex.org/keywords/jc-virus-reactivation"}],"legacy_keywords":["Polyomavirus","Merkel Cell Carcinoma","Progressive Multifocal Leukoencephalopathy","Natalizumab","Renal Transplantation","T antigen mutations","Viral Oncoproteins","Immunosuppression","Viral Nephropathy","JC Virus"],"openalex_id":"https://openalex.org/T11827","source_created_date":"2024-01-23T15:27:12","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T11827","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11827","works_count":28614,"label":"Polyomavirus and related diseases","provider":"openalex","revision":"53031eeb346c73a4","taxonomy_revision":"f050b5d4780b1289","title":"Polyomavirus and related diseases","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249525065245162","address_version":"morton4x16-v1","coordinates":[4,27,2730,11827],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}