{"cited_by_count":1670185,"description":"This cluster of papers focuses on the activation of dioxygen at metalloenzyme active sites, encompassing mechanisms of oxygenation reactions, proton-coupled electron transfer, non-heme iron catalysts, cytochrome P450 enzymes, high-valent intermediates, methane monooxygenase, superoxide dismutases, and ribonucleotide reductases.","display_name":"Metal-Catalyzed Oxygenation Mechanisms","domain_id":"3","external_ids":{"openalex":"https://openalex.org/T11747","wikipedia":"https://en.wikipedia.org/wiki/Dioxygen_activation"},"field_id":"16","id":"T11747","keywords":[{"display_name":"oxygen activation","id":"oxygen-activation","score":0.2708,"url":"https://openalex.org/keywords/oxygen-activation"},{"display_name":"dioxygen activation","id":"dioxygen-activation","score":0.744,"url":"https://openalex.org/keywords/dioxygen-activation"},{"display_name":"compound I","id":"compound-i","score":0.6658,"url":"https://openalex.org/keywords/compound-i"},{"display_name":"oxygen atom transfer","id":"oxygen-atom-transfer","score":0.39,"url":"https://openalex.org/keywords/oxygen-atom-transfer"},{"display_name":"biomimetic catalysis","id":"biomimetic-catalysis","score":0.2535,"url":"https://openalex.org/keywords/biomimetic-catalysis"},{"display_name":"heme enzymes","id":"heme-enzymes","score":0.4146,"url":"https://openalex.org/keywords/heme-enzymes"},{"display_name":"cytochrome P450cam","id":"cytochrome-p450cam","score":0.6522,"url":"https://openalex.org/keywords/cytochrome-p450cam"},{"display_name":"non-heme iron enzymes","id":"nonheme-iron-enzymes","score":0.7112,"url":"https://openalex.org/keywords/nonheme-iron-enzymes"},{"display_name":"copper proteins","id":"copper-proteins","score":0.2868,"url":"https://openalex.org/keywords/copper-proteins"},{"display_name":"catechol oxidation","id":"catechol-oxidation","score":0.2921,"url":"https://openalex.org/keywords/catechol-oxidation"},{"display_name":"copper enzymes","id":"copper-enzymes","score":0.2595,"url":"https://openalex.org/keywords/copper-enzymes"},{"display_name":"tyrosyl radical","id":"tyrosyl-radical","score":0.4094,"url":"https://openalex.org/keywords/tyrosyl-radical"},{"display_name":"heme peroxidase","id":"heme-peroxidase","score":0.2271,"url":"https://openalex.org/keywords/heme-peroxidase"},{"display_name":"multicopper oxidase","id":"multicopper-oxidase","score":0.2392,"url":"https://openalex.org/keywords/multicopper-oxidase"},{"display_name":"model complexes","id":"model-complexes","score":0.349,"url":"https://openalex.org/keywords/model-complexes"},{"display_name":"C\u2013H oxidation","id":"c-h-oxidation","score":0.2227,"url":"https://openalex.org/keywords/c-h-oxidation"},{"display_name":"cytochrome c peroxidase","id":"cytochrome-c-peroxidase","score":0.2852,"url":"https://openalex.org/keywords/cytochrome-c-peroxidase"},{"display_name":"compound II","id":"compound-ii","score":0.5259,"url":"https://openalex.org/keywords/compound-ii"},{"display_name":"dioxygen reduction","id":"dioxygen-reduction","score":0.4648,"url":"https://openalex.org/keywords/dioxygen-reduction"},{"display_name":"methane monooxygenase","id":"methane-monooxygenase","score":0.3498,"url":"https://openalex.org/keywords/methane-monooxygenase"},{"display_name":"O-O bond cleavage","id":"o-o-bond-cleavage","score":0.3766,"url":"https://openalex.org/keywords/o-o-bond-cleavage"},{"display_name":"dioxygen binding","id":"dioxygen-binding","score":0.5664,"url":"https://openalex.org/keywords/dioxygen-binding"},{"display_name":"metalloenzyme mimics","id":"metalloenzyme-mimics","score":0.4285,"url":"https://openalex.org/keywords/metalloenzyme-mimics"},{"display_name":"dioxygenase","id":"dioxygenase","score":0.2797,"url":"https://openalex.org/keywords/dioxygenase"},{"display_name":"heme a","id":"heme-a","score":0.5594,"url":"https://openalex.org/keywords/heme-a"}],"legacy_keywords":["Dioxygen Activation","Metalloenzyme","Oxygenation Reactions","Proton-Coupled Electron Transfer","Non-Heme Iron Catalysts","Cytochrome P450 Enzymes","High-Valent Intermediates","Methane Monooxygenase","Superoxide Dismutases","Ribonucleotide Reductases"],"openalex_id":"https://openalex.org/T11747","source_created_date":"2024-01-23T15:27:11","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1604","url":"/topics/T11747","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11747","works_count":56739,"label":"Metal-Catalyzed Oxygenation Mechanisms","provider":"openalex","revision":"986990630fc38b6e","taxonomy_revision":"f050b5d4780b1289","title":"Metal-Catalyzed Oxygenation Mechanisms","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36183040241829017","address_version":"morton4x16-v1","coordinates":[3,16,1604,11747],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}