{"cited_by_count":877328,"description":"This cluster of papers focuses on the genetic basis and clinical manifestations of primary immunodeficiency disorders, including immune dysregulation, Th17 cell deficiency, common variable immunodeficiency, and defects in the interferon-? pathway. It also discusses the use of hematopoietic stem cell transplantation and immunoglobulin replacement therapy in the management of these disorders.","display_name":"Immunodeficiency and Autoimmune Disorders","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11725","wikipedia":"https://en.wikipedia.org/wiki/Primary_immunodeficiency"},"field_id":"24","id":"T11725","keywords":[{"display_name":"primary immunodeficiency","id":"primary-immunodeficiency","score":0.7089,"url":"https://openalex.org/keywords/primary-immunodeficiency"},{"display_name":"common variable immunodeficiency","id":"common-variable-immunodeficiency","score":0.751,"url":"https://openalex.org/keywords/common-variable-immunodeficiency"},{"display_name":"hypogammaglobulinemia","id":"hypogammaglobulinemia","score":0.4384,"url":"https://openalex.org/keywords/hypogammaglobulinemia"},{"display_name":"severe combined immunodeficiency","id":"severe-combined-immunodeficiency","score":0.4913,"url":"https://openalex.org/keywords/severe-combined-immunodeficiency"},{"display_name":"antibody deficiency","id":"immunoglobulin-deficiency","score":0.6643,"url":"https://openalex.org/keywords/immunoglobulin-deficiency"},{"display_name":"recurrent infections","id":"recurrent-infections","score":0.2108,"url":"https://openalex.org/keywords/recurrent-infections"},{"display_name":"immunoglobulin replacement therapy","id":"immunoglobulin-replacement-therapy","score":0.6925,"url":"https://openalex.org/keywords/immunoglobulin-replacement-therapy"},{"display_name":"X-linked agammaglobulinemia","id":"x-linked-agammaglobulinemia","score":0.6965,"url":"https://openalex.org/keywords/x-linked-agammaglobulinemia"},{"display_name":"Wiskott-Aldrich syndrome","id":"wiskott-aldrich-syndrome","score":0.5368,"url":"https://openalex.org/keywords/wiskott-aldrich-syndrome"},{"display_name":"chronic granulomatous disease","id":"chronic-granulomatous-disease","score":0.26,"url":"https://openalex.org/keywords/chronic-granulomatous-disease"},{"display_name":"combined immunodeficiency","id":"combined-immunodeficiency","score":0.7716,"url":"https://openalex.org/keywords/combined-immunodeficiency"},{"display_name":"IgA deficiency","id":"iga-deficiency","score":0.4695,"url":"https://openalex.org/keywords/iga-deficiency"},{"display_name":"secondary immunodeficiency","id":"secondary-immunodeficiency","score":0.4242,"url":"https://openalex.org/keywords/secondary-immunodeficiency"},{"display_name":"hyper-IgE syndrome","id":"hyper-ige-syndrome","score":0.6663,"url":"https://openalex.org/keywords/hyper-ige-syndrome"},{"display_name":"agammaglobulinemia","id":"agammaglobulinemia","score":0.6347,"url":"https://openalex.org/keywords/agammaglobulinemia"},{"display_name":"T cell deficiency","id":"t-cell-immunodeficiency","score":0.3252,"url":"https://openalex.org/keywords/t-cell-immunodeficiency"},{"display_name":"selective IgA deficiency","id":"selective-iga-deficiency","score":0.6678,"url":"https://openalex.org/keywords/selective-iga-deficiency"},{"display_name":"B cell deficiency","id":"b-cell-deficiency","score":0.4825,"url":"https://openalex.org/keywords/b-cell-deficiency"},{"display_name":"chronic mucocutaneous candidiasis","id":"chronic-mucocutaneous-candidiasis","score":0.6428,"url":"https://openalex.org/keywords/chronic-mucocutaneous-candidiasis"},{"display_name":"Chediak-Higashi syndrome","id":"chediak-higashi-syndrome","score":0.5745,"url":"https://openalex.org/keywords/chediak-higashi-syndrome"},{"display_name":"pediatric immunology","id":"pediatric-immunology","score":0.3902,"url":"https://openalex.org/keywords/pediatric-immunology"},{"display_name":"autoimmune lymphoproliferative syndrome","id":"autoimmune-lymphoproliferative-syndrome","score":0.5974,"url":"https://openalex.org/keywords/autoimmune-lymphoproliferative-syndrome"},{"display_name":"primary antibody deficiency","id":"primary-antibody-deficiency","score":0.833,"url":"https://openalex.org/keywords/primary-antibody-deficiency"},{"display_name":"subcutaneous immunoglobulin","id":"subcutaneous-immunoglobulin","score":0.5394,"url":"https://openalex.org/keywords/subcutaneous-immunoglobulin"},{"display_name":"pediatric immunodeficiency","id":"pediatric-immunodeficiency","score":0.7612,"url":"https://openalex.org/keywords/pediatric-immunodeficiency"}],"legacy_keywords":["Primary Immunodeficiency","Genetic Mutations","Immune Dysregulation","Human Inborn Errors","Th17 Cell Deficiency","Common Variable Immunodeficiency","Hematopoietic Stem Cell Transplantation","Interferon-? Pathway Defects","B Cell Abnormalities","Immunoglobulin Replacement Therapy"],"openalex_id":"https://openalex.org/T11725","source_created_date":"2024-01-23T15:27:11","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T11725","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11725","works_count":59737,"label":"Immunodeficiency and Autoimmune Disorders","provider":"openalex","revision":"2a580dcfaf09377f","taxonomy_revision":"f050b5d4780b1289","title":"Immunodeficiency and Autoimmune Disorders","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248753237305421","address_version":"morton4x16-v1","coordinates":[1,24,2403,11725],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}