{"cited_by_count":1656478,"description":"This cluster of papers focuses on the innate immune response to viral infection, particularly the role of pattern recognition receptors such as RIG-I-like receptors and the cGAS-STING pathway in detecting viral nucleic acids and activating antiviral signaling. It also explores the mechanisms of interferon signaling, immune sensing of DNA and RNA viruses, and the regulation of antiviral responses.","display_name":"interferon and immune responses","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11668","wikipedia":"https://en.wikipedia.org/wiki/Innate_immune_system"},"field_id":"24","id":"T11668","keywords":[{"display_name":"type I interferon","id":"type-i-interferon","score":0.3695,"url":"https://openalex.org/keywords/type-i-interferon"},{"display_name":"interferon","id":"interferon","score":0.2944,"url":"https://openalex.org/keywords/interferon"},{"display_name":"interferon-beta","id":"interferon-beta","score":0.2353,"url":"https://openalex.org/keywords/interferon-beta"},{"display_name":"interferon-stimulated genes","id":"interferon-stimulated-genes","score":0.4101,"url":"https://openalex.org/keywords/interferon-stimulated-genes"},{"display_name":"antiviral innate immunity","id":"antiviral-innate-immunity","score":0.5897,"url":"https://openalex.org/keywords/antiviral-innate-immunity"},{"display_name":"antiviral immunity","id":"antiviral-immunity","score":0.2121,"url":"https://openalex.org/keywords/antiviral-immunity"},{"display_name":"interferon signaling","id":"interferon-signaling","score":0.312,"url":"https://openalex.org/keywords/interferon-signaling"},{"display_name":"STING","id":"sting","score":0.4317,"url":"https://openalex.org/keywords/sting"},{"display_name":"RIG-I","id":"rig-i","score":0.5625,"url":"https://openalex.org/keywords/rig-i"},{"display_name":"interferon induction","id":"interferon-induction","score":0.6614,"url":"https://openalex.org/keywords/interferon-induction"},{"display_name":"IRF3","id":"irf3","score":0.4895,"url":"https://openalex.org/keywords/irf3"},{"display_name":"interferon lambda","id":"interferon-lambda","score":0.3117,"url":"https://openalex.org/keywords/interferon-lambda"},{"display_name":"cGAS-STING pathway","id":"cgas-sting-pathway","score":0.3091,"url":"https://openalex.org/keywords/cgas-sting-pathway"},{"display_name":"interferon production","id":"interferon-production","score":0.6008,"url":"https://openalex.org/keywords/interferon-production"},{"display_name":"MDA5","id":"mda5","score":0.4658,"url":"https://openalex.org/keywords/mda5"},{"display_name":"type I interferon signaling","id":"type-i-interferon-signaling","score":0.3348,"url":"https://openalex.org/keywords/type-i-interferon-signaling"},{"display_name":"antiviral defense","id":"antiviral-defense","score":0.2533,"url":"https://openalex.org/keywords/antiviral-defense"},{"display_name":"antiviral response","id":"antiviral-response","score":0.3132,"url":"https://openalex.org/keywords/antiviral-response"},{"display_name":"cGAS","id":"cgas","score":0.5072,"url":"https://openalex.org/keywords/cgas"},{"display_name":"MAVS","id":"mavs","score":0.6147,"url":"https://openalex.org/keywords/mavs"},{"display_name":"cytosolic DNA sensing","id":"cytosolic-dna-sensing","score":0.6119,"url":"https://openalex.org/keywords/cytosolic-dna-sensing"},{"display_name":"TBK1","id":"tbk1","score":0.3763,"url":"https://openalex.org/keywords/tbk1"},{"display_name":"IRF7","id":"irf7","score":0.3746,"url":"https://openalex.org/keywords/irf7"},{"display_name":"interferon response","id":"interferon-response","score":0.2249,"url":"https://openalex.org/keywords/interferon-response"},{"display_name":"antiviral signaling","id":"antiviral-signaling","score":0.6269,"url":"https://openalex.org/keywords/antiviral-signaling"}],"legacy_keywords":["Innate Immunity","Viral Infection","Interferon Signaling","Pattern Recognition Receptors","cGAS-STING Pathway","RIG-I-like Receptors","Antiviral Response","Type I Interferons","Immune Sensing","Inflammatory Disease"],"openalex_id":"https://openalex.org/T11668","source_created_date":"2024-01-23T15:27:11","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T11668","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11668","works_count":57709,"label":"interferon and immune responses","provider":"openalex","revision":"388d77397db81493","taxonomy_revision":"f050b5d4780b1289","title":"interferon and immune responses","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248753103579205","address_version":"morton4x16-v1","coordinates":[1,24,2403,11668],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}