{"cited_by_count":1043451,"description":"This cluster of papers explores the occurrence, classification, and biological function of hydrogenases, including their role in nitrogen fixation, structure-function relationships of iron-sulfur clusters, molecular catalysis for hydrogen production, biomimetic models of enzyme active sites, and the application of hydrogenases in photosynthetic systems and mitochondrial iron-sulfur biogenesis.","display_name":"Metalloenzymes and iron-sulfur proteins","domain_id":"3","external_ids":{"openalex":"https://openalex.org/T11626","wikipedia":"https://en.wikipedia.org/wiki/Hydrogenase"},"field_id":"21","id":"T11626","keywords":[{"display_name":"iron-sulfur clusters","id":"iron-sulfur-clusters","score":0.4803,"url":"https://openalex.org/keywords/iron-sulfur-clusters"},{"display_name":"nitrogenase","id":"nitrogenase","score":0.5093,"url":"https://openalex.org/keywords/nitrogenase"},{"display_name":"hydrogenase","id":"hydrogenase","score":0.5273,"url":"https://openalex.org/keywords/hydrogenase"},{"display_name":"iron-sulfur proteins","id":"iron-sulfur-proteins","score":0.4777,"url":"https://openalex.org/keywords/iron-sulfur-proteins"},{"display_name":"ferredoxin","id":"ferredoxin","score":0.3919,"url":"https://openalex.org/keywords/ferredoxin"},{"display_name":"[NiFe] hydrogenase","id":"nife-hydrogenase","score":0.7869,"url":"https://openalex.org/keywords/nife-hydrogenase"},{"display_name":"[4Fe-4S] cluster","id":"4fe-4s-cluster","score":0.6526,"url":"https://openalex.org/keywords/4fe-4s-cluster"},{"display_name":"[FeFe]-hydrogenase","id":"fefe-hydrogenase","score":0.813,"url":"https://openalex.org/keywords/fefe-hydrogenase"},{"display_name":"Azotobacter vinelandii","id":"azotobacter-vinelandii","score":0.3138,"url":"https://openalex.org/keywords/azotobacter-vinelandii"},{"display_name":"iron-sulfur cluster assembly","id":"iron-sulfur-cluster-assembly","score":0.4466,"url":"https://openalex.org/keywords/iron-sulfur-cluster-assembly"},{"display_name":"[2Fe-2S] cluster","id":"2fe-2s-cluster","score":0.5862,"url":"https://openalex.org/keywords/2fe-2s-cluster"},{"display_name":"molybdenum cofactor","id":"molybdenum-cofactor","score":0.5708,"url":"https://openalex.org/keywords/molybdenum-cofactor"},{"display_name":"molybdenum enzymes","id":"molybdenum-enzymes","score":0.6116,"url":"https://openalex.org/keywords/molybdenum-enzymes"},{"display_name":"MoFe protein","id":"mofe-protein","score":0.9466,"url":"https://openalex.org/keywords/mofe-protein"},{"display_name":"Clostridium pasteurianum","id":"clostridium-pasteurianum","score":0.4274,"url":"https://openalex.org/keywords/clostridium-pasteurianum"},{"display_name":"FeMo cofactor","id":"femo-cofactor","score":0.9062,"url":"https://openalex.org/keywords/femo-cofactor"},{"display_name":"rubredoxin","id":"rubredoxin","score":0.4362,"url":"https://openalex.org/keywords/rubredoxin"},{"display_name":"flavodoxin","id":"flavodoxin","score":0.3458,"url":"https://openalex.org/keywords/flavodoxin"},{"display_name":"iron-molybdenum cofactor","id":"iron-molybdenum-cofactor","score":0.8848,"url":"https://openalex.org/keywords/iron-molybdenum-cofactor"},{"display_name":"carbon monoxide dehydrogenase","id":"carbon-monoxide-dehydrogenase","score":0.4327,"url":"https://openalex.org/keywords/carbon-monoxide-dehydrogenase"},{"display_name":"Fe4S4 cluster","id":"fe4s4-cluster","score":0.7276,"url":"https://openalex.org/keywords/fe4s4-cluster"},{"display_name":"Fe protein","id":"fe-protein","score":0.9501,"url":"https://openalex.org/keywords/fe-protein"},{"display_name":"Desulfovibrio vulgaris","id":"desulfovibrio-vulgaris","score":0.2315,"url":"https://openalex.org/keywords/desulfovibrio-vulgaris"},{"display_name":"hydrogen metabolism","id":"hydrogen-metabolism","score":0.379,"url":"https://openalex.org/keywords/hydrogen-metabolism"},{"display_name":"hydrogenase active site","id":"hydrogenase-active-site","score":0.9462,"url":"https://openalex.org/keywords/hydrogenase-active-site"}],"legacy_keywords":["Hydrogenases","Nitrogen Fixation","Iron-Sulfur Clusters","Molecular Catalysis","Electrocatalytic Hydrogen Production","Biomimetic Models","Enzyme Structure-Function","Photosynthetic Systems","Molybdenum Cofactor","Mitochondrial Iron-Sulfur Biogenesis"],"openalex_id":"https://openalex.org/T11626","source_created_date":"2024-01-23T15:27:11","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2105","url":"/topics/T11626","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11626","works_count":37958,"label":"Metalloenzymes and iron-sulfur proteins","provider":"openalex","revision":"6ea3d3b7c7c125ab","taxonomy_revision":"f050b5d4780b1289","title":"Metalloenzymes and iron-sulfur proteins","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248733851501207","address_version":"morton4x16-v1","coordinates":[3,21,2105,11626],"answer_status":"Directory metadata; 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