{"cited_by_count":319552,"description":"This cluster of papers explores the biological activities of sesquiterpene lactones, particularly their potential in cancer treatment. The research covers apoptosis induction, anti-inflammatory effects, NF-?B inhibition, pharmacological properties, and the chemistry of sesquiterpene lactones derived from various medicinal plants. Additionally, it investigates the potential of compounds like thapsigargin in cancer therapy.","display_name":"Sesquiterpenes and Asteraceae Studies","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11547","wikipedia":"https://en.wikipedia.org/wiki/Sesquiterpene_lactone"},"field_id":"13","id":"T11547","keywords":[{"display_name":"sesquiterpene lactones","id":"sesquiterpene-lactones","score":0.2972,"url":"https://openalex.org/keywords/sesquiterpene-lactones"},{"display_name":"guaianolides","id":"guaianolides","score":0.6414,"url":"https://openalex.org/keywords/guaianolides"},{"display_name":"sesquiterpene esters","id":"sesquiterpene-esters","score":0.8705,"url":"https://openalex.org/keywords/sesquiterpene-esters"},{"display_name":"parthenolide","id":"parthenolide","score":0.3967,"url":"https://openalex.org/keywords/parthenolide"},{"display_name":"germacranolides","id":"germacranolides","score":0.8742,"url":"https://openalex.org/keywords/germacranolides"},{"display_name":"eudesmanolides","id":"eudesmanolides","score":0.7902,"url":"https://openalex.org/keywords/eudesmanolides"},{"display_name":"furanoeremophilanes","id":"furanoeremophilanes","score":0.9067,"url":"https://openalex.org/keywords/furanoeremophilanes"},{"display_name":"eudesmane sesquiterpenes","id":"eudesmane-sesquiterpenoids","score":0.4999,"url":"https://openalex.org/keywords/eudesmane-sesquiterpenoids"},{"display_name":"costunolide","id":"costunolide","score":0.4575,"url":"https://openalex.org/keywords/costunolide"},{"display_name":"monoesters","id":"monoesters","score":0.3967,"url":"https://openalex.org/keywords/monoesters"},{"display_name":"bicyclic sesquiterpenes","id":"bicyclic-sesquiterpenes","score":0.4285,"url":"https://openalex.org/keywords/bicyclic-sesquiterpenes"},{"display_name":"bicyclic sesquiterpene esters","id":"bicyclic-sesquiterpene-esters","score":0.9751,"url":"https://openalex.org/keywords/bicyclic-sesquiterpene-esters"},{"display_name":"alantolactone","id":"alantolactone","score":0.535,"url":"https://openalex.org/keywords/alantolactone"},{"display_name":"dehydrocostus lactone","id":"dehydrocostus-lactone","score":0.438,"url":"https://openalex.org/keywords/dehydrocostus-lactone"},{"display_name":"pseudoguaianolides","id":"pseudoguaianolides","score":0.8089,"url":"https://openalex.org/keywords/pseudoguaianolides"},{"display_name":"eremophilane sesquiterpenes","id":"eremophilane-sesquiterpenes","score":0.5961,"url":"https://openalex.org/keywords/eremophilane-sesquiterpenes"},{"display_name":"eremophilanes","id":"eremophilanes","score":0.7957,"url":"https://openalex.org/keywords/eremophilanes"},{"display_name":"santonin","id":"santonin","score":0.2196,"url":"https://openalex.org/keywords/santonin"},{"display_name":"eudesmanes","id":"eudesmanes","score":0.6473,"url":"https://openalex.org/keywords/eudesmanes"},{"display_name":"isoalantolactone","id":"isoalantolactone","score":0.5501,"url":"https://openalex.org/keywords/isoalantolactone"},{"display_name":"tricyclic sesquiterpene esters","id":"tricyclic-sesquiterpene-esters","score":0.9938,"url":"https://openalex.org/keywords/tricyclic-sesquiterpene-esters"},{"display_name":"helenalin","id":"helenalin","score":0.4435,"url":"https://openalex.org/keywords/helenalin"},{"display_name":"guaiane sesquiterpenes","id":"guaiane-sesquiterpenes","score":0.4689,"url":"https://openalex.org/keywords/guaiane-sesquiterpenes"},{"display_name":"Saussurea lappa","id":"saussurea-lappa","score":0.22,"url":"https://openalex.org/keywords/saussurea-lappa"},{"display_name":"\u03b1-methylene-\u03b3-lactones","id":"alpha-methylene-gamma-lactones","score":0.3566,"url":"https://openalex.org/keywords/alpha-methylene-gamma-lactones"}],"legacy_keywords":["Sesquiterpene Lactones","Cancer","Apoptosis","Anti-inflammatory","NF-?B","Pharmacology","Chemistry","Antioxidant","Medicinal Plants","Thapsigargin"],"openalex_id":"https://openalex.org/T11547","source_created_date":"2024-01-23T15:27:11","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1306","url":"/topics/T11547","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11547","works_count":25283,"label":"Sesquiterpenes and Asteraceae Studies","provider":"openalex","revision":"1e156cec0074e19e","taxonomy_revision":"f050b5d4780b1289","title":"Sesquiterpenes and Asteraceae Studies","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36182780187304651","address_version":"morton4x16-v1","coordinates":[1,13,1306,11547],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}