{"cited_by_count":629021,"description":"This cluster of papers focuses on the cardiotoxic effects of various cancer treatments, particularly anthracyclines and related drugs like doxorubicin and trastuzumab. It explores the molecular mechanisms, pharmacologic developments, early detection, prevention, and management of cardiotoxicity in cancer patients. The papers also discuss the long-term cardiovascular complications and survival outcomes in individuals undergoing these treatments.","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11535","wikipedia":"https://en.wikipedia.org/wiki/Cardiotoxicity"},"field_id":"27","id":"T11535","keywords":[{"display_name":"cardiotoxicity","id":"cardiotoxicity","score":0.2952,"url":"https://openalex.org/keywords/cardiotoxicity"},{"display_name":"anthracycline cardiotoxicity","id":"anthracycline-induced-cardiotoxicity","score":0.7963,"url":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity"},{"display_name":"chemotherapy-induced cardiotoxicity","id":"chemotherapy-induced-cardiotoxicity","score":0.8373,"url":"https://openalex.org/keywords/chemotherapy-induced-cardiotoxicity"},{"display_name":"doxorubicin 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cardiomyopathy","id":"chemotherapy-induced-cardiomyopathy","score":0.7934,"url":"https://openalex.org/keywords/chemotherapy-induced-cardiomyopathy"},{"display_name":"cancer therapy-related cardiotoxicity","id":"cancer-therapy-related-cardiotoxicity","score":0.7221,"url":"https://openalex.org/keywords/cancer-therapy-related-cardiotoxicity"},{"display_name":"cardiotoxicity prevention","id":"cardiotoxicity-prevention","score":0.8767,"url":"https://openalex.org/keywords/cardiotoxicity-prevention"},{"display_name":"early detection of cardiotoxicity","id":"early-detection-of-cardiotoxicity","score":0.9427,"url":"https://openalex.org/keywords/early-detection-of-cardiotoxicity"},{"display_name":"cumulative anthracycline dose","id":"cumulative-anthracycline-dose","score":0.8986,"url":"https://openalex.org/keywords/cumulative-anthracycline-dose"},{"display_name":"cancer therapy-related cardiac dysfunction","id":"cancer-therapy-related-cardiac-dysfunction","score":0.8804,"url":"https://openalex.org/keywords/cancer-therapy-related-cardiac-dysfunction"},{"display_name":"radiation-induced heart disease","id":"radiation-induced-heart-disease","score":0.2385,"url":"https://openalex.org/keywords/radiation-induced-heart-disease"},{"display_name":"drug-induced cardiomyopathy","id":"drug-induced-cardiomyopathy","score":0.2887,"url":"https://openalex.org/keywords/drug-induced-cardiomyopathy"},{"display_name":"adriamycin cardiotoxicity","id":"adriamycin-cardiotoxicity","score":0.6263,"url":"https://openalex.org/keywords/adriamycin-cardiotoxicity"},{"display_name":"doxorubicin-induced cardiomyopathy","id":"doxorubicin-induced-cardiomyopathy","score":0.5874,"url":"https://openalex.org/keywords/doxorubicin-induced-cardiomyopathy"},{"display_name":"cardiac function monitoring","id":"cardiac-function-monitoring","score":0.2657,"url":"https://openalex.org/keywords/cardiac-function-monitoring"},{"display_name":"subclinical cardiotoxicity","id":"subclinical-cardiotoxicity","score":0.9101,"url":"https://openalex.org/keywords/subclinical-cardiotoxicity"},{"display_name":"trastuzumab cardiotoxicity","id":"trastuzumab-cardiotoxicity","score":0.7184,"url":"https://openalex.org/keywords/trastuzumab-cardiotoxicity"},{"display_name":"cardiotoxicity prediction","id":"cardiotoxicity-prediction","score":0.4361,"url":"https://openalex.org/keywords/cardiotoxicity-prediction"},{"display_name":"cardiotoxicity monitoring","id":"cardiotoxicity-monitoring","score":0.8173,"url":"https://openalex.org/keywords/cardiotoxicity-monitoring"},{"display_name":"late cardiotoxicity","id":"late-cardiotoxicity","score":0.8757,"url":"https://openalex.org/keywords/late-cardiotoxicity"}],"legacy_keywords":["Anthracyclines","Doxorubicin","Cardiomyopathy","Chemotherapy","Cardiovascular Complications","Trastuzumab","Oxidative Stress","Cardiac Dysfunction","Prevention","Survivors"],"openalex_id":"https://openalex.org/T11535","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2705","url":"/topics/T11535","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11535","works_count":35090,"label":"Chemotherapy-induced cardiotoxicity and mitigation","provider":"openalex","revision":"981845be8c37c5b8","taxonomy_revision":"f050b5d4780b1289","title":"Chemotherapy-induced cardiotoxicity and mitigation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36249009656342958","address_version":"morton4x16-v1","coordinates":[4,27,2705,11535],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}