{"cited_by_count":1016120,"description":"This cluster of papers explores the immunological mechanisms involved in pregnancy, focusing on the interactions at the fetal-maternal interface, including the roles of decidual NK cells, regulatory T cells, HLA-G, and the Th1/Th2 paradigm. It delves into topics such as implantation, recurrent pregnancy loss, maternal-fetal tolerance, and endometrial receptivity.","display_name":"Reproductive System and Pregnancy","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11510","wikipedia":"https://en.wikipedia.org/wiki/Immunology_of_pregnancy"},"field_id":"24","id":"T11510","keywords":[{"display_name":"recurrent pregnancy loss","id":"recurrent-pregnancy-loss","score":0.3907,"url":"https://openalex.org/keywords/recurrent-pregnancy-loss"},{"display_name":"endometrium","id":"endometrium","score":0.2317,"url":"https://openalex.org/keywords/endometrium"},{"display_name":"embryo implantation","id":"embryo-implantation","score":0.3963,"url":"https://openalex.org/keywords/embryo-implantation"},{"display_name":"endometrial receptivity","id":"endometrial-receptivity","score":0.3763,"url":"https://openalex.org/keywords/endometrial-receptivity"},{"display_name":"trophoblast","id":"trophoblast","score":0.2369,"url":"https://openalex.org/keywords/trophoblast"},{"display_name":"decidua","id":"decidua","score":0.5249,"url":"https://openalex.org/keywords/decidua"},{"display_name":"maternal-fetal immune tolerance","id":"maternal-fetal-immune-tolerance","score":0.7059,"url":"https://openalex.org/keywords/maternal-fetal-immune-tolerance"},{"display_name":"maternal-fetal interface","id":"maternal-fetal-interface","score":0.4591,"url":"https://openalex.org/keywords/maternal-fetal-interface"},{"display_name":"implantation","id":"implantation","score":0.2942,"url":"https://openalex.org/keywords/implantation"},{"display_name":"decidualization","id":"decidualization","score":0.6093,"url":"https://openalex.org/keywords/decidualization"},{"display_name":"pregnancy immunology","id":"pregnancy-immunology","score":0.7383,"url":"https://openalex.org/keywords/pregnancy-immunology"},{"display_name":"recurrent implantation failure","id":"recurrent-implantation-failure","score":0.5778,"url":"https://openalex.org/keywords/recurrent-implantation-failure"},{"display_name":"endometrial stromal cells","id":"endometrial-stromal-cells","score":0.3277,"url":"https://openalex.org/keywords/endometrial-stromal-cells"},{"display_name":"trophoblast invasion","id":"trophoblast-invasion","score":0.255,"url":"https://openalex.org/keywords/trophoblast-invasion"},{"display_name":"implantation failure","id":"implantation-failure","score":0.4354,"url":"https://openalex.org/keywords/implantation-failure"},{"display_name":"HLA-G","id":"hla-g","score":0.3151,"url":"https://openalex.org/keywords/hla-g"},{"display_name":"early pregnancy loss","id":"early-pregnancy-loss","score":0.2592,"url":"https://openalex.org/keywords/early-pregnancy-loss"},{"display_name":"threatened abortion","id":"threatened-abortion","score":0.2714,"url":"https://openalex.org/keywords/threatened-abortion"},{"display_name":"reproductive immunology","id":"reproductive-immunology","score":0.6185,"url":"https://openalex.org/keywords/reproductive-immunology"},{"display_name":"implantation window","id":"window-of-implantation","score":0.6701,"url":"https://openalex.org/keywords/window-of-implantation"},{"display_name":"pregnancy maintenance","id":"pregnancy-maintenance","score":0.3148,"url":"https://openalex.org/keywords/pregnancy-maintenance"},{"display_name":"uterine natural killer cells","id":"uterine-natural-killer-cells","score":0.7724,"url":"https://openalex.org/keywords/uterine-natural-killer-cells"},{"display_name":"decidual cells","id":"decidual-cells","score":0.4937,"url":"https://openalex.org/keywords/decidual-cells"},{"display_name":"unexplained recurrent spontaneous abortion","id":"unexplained-recurrent-miscarriage","score":0.8142,"url":"https://openalex.org/keywords/unexplained-recurrent-miscarriage"},{"display_name":"extravillous trophoblast","id":"extravillous-trophoblast","score":0.2549,"url":"https://openalex.org/keywords/extravillous-trophoblast"}],"legacy_keywords":["Decidual NK Cells","Regulatory T Cells","Fetal-Maternal Interface","Implantation","Recurrent Pregnancy Loss","Maternal-Fetal Tolerance","HLA-G","Th1/Th2 Paradigm","Endometrial Receptivity","Immune Regulation"],"openalex_id":"https://openalex.org/T11510","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T11510","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11510","works_count":66012,"label":"Reproductive System and Pregnancy","provider":"openalex","revision":"8203db19ae7e67cf","taxonomy_revision":"f050b5d4780b1289","title":"Reproductive System and Pregnancy","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248718886447301","address_version":"morton4x16-v1","coordinates":[1,24,2403,11510],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}