{"cited_by_count":1760460,"description":"This cluster of papers focuses on the role of STAT3 in cancer inflammation and immunity, with a particular emphasis on its involvement in cytokine signaling, regulation of the JAK/STAT pathway, modulation of the immune response, and its impact on the tumor microenvironment. The cluster also explores the interplay between STAT3, IL-6, and SOCS proteins in transcriptional control, inflammation, and cancer progression.","display_name":"Cytokine Signaling Pathways and Interactions","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11503","wikipedia":"https://en.wikipedia.org/wiki/STAT3"},"field_id":"27","id":"T11503","keywords":[{"display_name":"cytokine signaling","id":"cytokine-signaling","score":0.2813,"url":"https://openalex.org/keywords/cytokine-signaling"},{"display_name":"gp130","id":"gp130","score":0.4551,"url":"https://openalex.org/keywords/gp130"},{"display_name":"SOCS3","id":"socs3","score":0.2233,"url":"https://openalex.org/keywords/socs3"},{"display_name":"cytokine receptors","id":"cytokine-receptors","score":0.3366,"url":"https://openalex.org/keywords/cytokine-receptors"},{"display_name":"STAT5","id":"stat5","score":0.2288,"url":"https://openalex.org/keywords/stat5"},{"display_name":"IL-6 receptor","id":"il-6-receptor","score":0.2104,"url":"https://openalex.org/keywords/il-6-receptor"},{"display_name":"suppressor of cytokine signaling","id":"suppressor-of-cytokine-signaling","score":0.4508,"url":"https://openalex.org/keywords/suppressor-of-cytokine-signaling"},{"display_name":"JAK1","id":"jak1","score":0.3182,"url":"https://openalex.org/keywords/jak1"},{"display_name":"SOCS1","id":"socs1","score":0.2199,"url":"https://openalex.org/keywords/socs1"},{"display_name":"STAT3 activation","id":"stat3-activation","score":0.3147,"url":"https://openalex.org/keywords/stat3-activation"},{"display_name":"IL-6 signaling","id":"il-6-signaling","score":0.2412,"url":"https://openalex.org/keywords/il-6-signaling"},{"display_name":"oncostatin M","id":"oncostatin-m","score":0.22,"url":"https://openalex.org/keywords/oncostatin-m"},{"display_name":"Janus kinase","id":"janus-kinase","score":0.5392,"url":"https://openalex.org/keywords/janus-kinase"},{"display_name":"STAT3 inhibitor","id":"stat3-inhibitor","score":0.4006,"url":"https://openalex.org/keywords/stat3-inhibitor"},{"display_name":"cytokine receptor signaling","id":"cytokine-receptor-signaling","score":0.4778,"url":"https://openalex.org/keywords/cytokine-receptor-signaling"},{"display_name":"soluble IL-6 receptor","id":"soluble-il-6-receptor","score":0.2336,"url":"https://openalex.org/keywords/soluble-il-6-receptor"},{"display_name":"JAK3","id":"jak3","score":0.2889,"url":"https://openalex.org/keywords/jak3"},{"display_name":"signal transducer and activator of transcription","id":"signal-transducer-and-activator-of-transcription","score":0.6388,"url":"https://openalex.org/keywords/signal-transducer-and-activator-of-transcription"},{"display_name":"TYK2","id":"tyk2","score":0.2553,"url":"https://openalex.org/keywords/tyk2"},{"display_name":"STAT5A","id":"stat5a","score":0.2869,"url":"https://openalex.org/keywords/stat5a"},{"display_name":"STAT proteins","id":"stat-proteins","score":0.6154,"url":"https://openalex.org/keywords/stat-proteins"},{"display_name":"AG490","id":"ag490","score":0.2434,"url":"https://openalex.org/keywords/ag490"},{"display_name":"STAT5B","id":"stat5b","score":0.2512,"url":"https://openalex.org/keywords/stat5b"},{"display_name":"GM-CSF receptor","id":"gm-csf-receptor","score":0.3784,"url":"https://openalex.org/keywords/gm-csf-receptor"},{"display_name":"STAT3 inhibition","id":"stat3-inhibition","score":0.2343,"url":"https://openalex.org/keywords/stat3-inhibition"}],"legacy_keywords":["STAT3","IL-6","JAK/STAT pathway","inflammation","cancer","cytokine signaling","immune response","SOCS proteins","tumor microenvironment","transcriptional control"],"openalex_id":"https://openalex.org/T11503","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T11503","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11503","works_count":45299,"label":"Cytokine Signaling Pathways and Interactions","provider":"openalex","revision":"0449ed89ecf5d455","taxonomy_revision":"f050b5d4780b1289","title":"Cytokine Signaling Pathways and Interactions","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248977590643178","address_version":"morton4x16-v1","coordinates":[4,27,2730,11503],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}