{"cited_by_count":744943,"description":"This cluster of papers explores the mechanisms and pathways involved in the clearance of waste products and metabolites from the brain, including the role of the glymphatic system, cerebrospinal fluid dynamics, lymphatic drainage, and the impact on neurological disorders such as Alzheimer's disease and hydrocephalus. It also delves into the structural and functional features of perivascular pathways, choroid plexus biology, and the implications for brain aging.","display_name":"Cerebrospinal fluid and hydrocephalus","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11406","wikipedia":"https://en.wikipedia.org/wiki/Glymphatic_system"},"field_id":"28","id":"T11406","keywords":[{"display_name":"hydrocephalus","id":"hydrocephalus","score":0.3195,"url":"https://openalex.org/keywords/hydrocephalus"},{"display_name":"ventriculoperitoneal shunt","id":"ventriculoperitoneal-shunt","score":0.4692,"url":"https://openalex.org/keywords/ventriculoperitoneal-shunt"},{"display_name":"cerebrospinal fluid flow","id":"cerebrospinal-fluid-flow","score":0.5015,"url":"https://openalex.org/keywords/cerebrospinal-fluid-flow"},{"display_name":"normal pressure hydrocephalus","id":"normal-pressure-hydrocephalus","score":0.665,"url":"https://openalex.org/keywords/normal-pressure-hydrocephalus"},{"display_name":"shunt complications","id":"shunt-complications","score":0.6024,"url":"https://openalex.org/keywords/shunt-complications"},{"display_name":"obstructive hydrocephalus","id":"obstructive-hydrocephalus","score":0.4635,"url":"https://openalex.org/keywords/obstructive-hydrocephalus"},{"display_name":"shunt malfunction","id":"shunt-failure","score":0.6643,"url":"https://openalex.org/keywords/shunt-failure"},{"display_name":"idiopathic normal pressure hydrocephalus","id":"idiopathic-normal-pressure-hydrocephalus","score":0.8158,"url":"https://openalex.org/keywords/idiopathic-normal-pressure-hydrocephalus"},{"display_name":"endoscopic third ventriculostomy","id":"endoscopic-third-ventriculostomy","score":0.717,"url":"https://openalex.org/keywords/endoscopic-third-ventriculostomy"},{"display_name":"pediatric hydrocephalus","id":"pediatric-hydrocephalus","score":0.8584,"url":"https://openalex.org/keywords/pediatric-hydrocephalus"},{"display_name":"choroid plexus","id":"choroid-plexus","score":0.2483,"url":"https://openalex.org/keywords/choroid-plexus"},{"display_name":"shunt revision","id":"shunt-revision","score":0.675,"url":"https://openalex.org/keywords/shunt-revision"},{"display_name":"third ventricle","id":"third-ventricle","score":0.2822,"url":"https://openalex.org/keywords/third-ventricle"},{"display_name":"glymphatic system","id":"glymphatic-system","score":0.4802,"url":"https://openalex.org/keywords/glymphatic-system"},{"display_name":"cerebrospinal fluid shunt","id":"csf-shunt","score":0.4701,"url":"https://openalex.org/keywords/csf-shunt"},{"display_name":"cerebrospinal fluid drainage","id":"cerebrospinal-fluid-drainage","score":0.3358,"url":"https://openalex.org/keywords/cerebrospinal-fluid-drainage"},{"display_name":"cerebrospinal fluid shunting","id":"cerebrospinal-fluid-shunting","score":0.519,"url":"https://openalex.org/keywords/cerebrospinal-fluid-shunting"},{"display_name":"cerebrospinal fluid dynamics","id":"cerebrospinal-fluid-dynamics","score":0.5162,"url":"https://openalex.org/keywords/cerebrospinal-fluid-dynamics"},{"display_name":"shunt infection","id":"shunt-infection","score":0.5281,"url":"https://openalex.org/keywords/shunt-infection"},{"display_name":"communicating hydrocephalus","id":"communicating-hydrocephalus","score":0.6218,"url":"https://openalex.org/keywords/communicating-hydrocephalus"},{"display_name":"brain ventricles","id":"cerebral-ventricles","score":0.3561,"url":"https://openalex.org/keywords/cerebral-ventricles"},{"display_name":"congenital hydrocephalus","id":"congenital-hydrocephalus","score":0.5165,"url":"https://openalex.org/keywords/congenital-hydrocephalus"},{"display_name":"perivascular spaces","id":"perivascular-spaces","score":0.2593,"url":"https://openalex.org/keywords/perivascular-spaces"},{"display_name":"aqueductal stenosis","id":"aqueductal-stenosis","score":0.6012,"url":"https://openalex.org/keywords/aqueductal-stenosis"},{"display_name":"cerebrospinal fluid production","id":"cerebrospinal-fluid-production","score":0.6435,"url":"https://openalex.org/keywords/cerebrospinal-fluid-production"}],"legacy_keywords":["Glymphatic System","Cerebrospinal Fluid","Lymphatic Drainage","Brain Waste Clearance","Perivascular Pathways","Choroid Plexus","CSF Flow","Neurological Disorders","Hydrocephalus","Brain Aging"],"openalex_id":"https://openalex.org/T11406","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2804","url":"/topics/T11406","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11406","works_count":58954,"label":"Cerebrospinal fluid and hydrocephalus","provider":"openalex","revision":"0ac88c25de403dc6","taxonomy_revision":"f050b5d4780b1289","title":"Cerebrospinal fluid and hydrocephalus","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248977515392641","address_version":"morton4x16-v1","coordinates":[1,28,2804,11406],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}