{"cited_by_count":1187990,"description":"This cluster of papers explores the diverse roles of mast cells in allergic disease, immune responses, and inflammation. It covers topics such as the activation and regulation of mast cells, their interactions with other immune cells, their involvement in allergic and non-allergic immune responses, and their significance in diseases such as mastocytosis. The cluster also delves into the molecular mechanisms, signaling pathways, and therapeutic implications related to mast cell biology.","display_name":"Mast cells and histamine","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11346","wikipedia":"https://en.wikipedia.org/wiki/Mast_cell"},"field_id":"24","id":"T11346","keywords":[{"display_name":"mast cells","id":"mast-cells","score":0.3999,"url":"https://openalex.org/keywords/mast-cells"},{"display_name":"histamine","id":"histamine","score":0.2258,"url":"https://openalex.org/keywords/histamine"},{"display_name":"histamine release","id":"histamine-release","score":0.5375,"url":"https://openalex.org/keywords/histamine-release"},{"display_name":"mast cell degranulation","id":"mast-cell-degranulation","score":0.4712,"url":"https://openalex.org/keywords/mast-cell-degranulation"},{"display_name":"mast cell activation","id":"mast-cell-activation","score":0.5363,"url":"https://openalex.org/keywords/mast-cell-activation"},{"display_name":"basophils","id":"basophils","score":0.3262,"url":"https://openalex.org/keywords/basophils"},{"display_name":"systemic mastocytosis","id":"systemic-mastocytosis","score":0.8228,"url":"https://openalex.org/keywords/systemic-mastocytosis"},{"display_name":"mastocytosis","id":"mastocytosis","score":0.6602,"url":"https://openalex.org/keywords/mastocytosis"},{"display_name":"allergic inflammation","id":"allergic-inflammation","score":0.2044,"url":"https://openalex.org/keywords/allergic-inflammation"},{"display_name":"Fc\u03b5RI","id":"fcepsilonri","score":0.5378,"url":"https://openalex.org/keywords/fcepsilonri"},{"display_name":"tryptase","id":"tryptase","score":0.3505,"url":"https://openalex.org/keywords/tryptase"},{"display_name":"compound 48/80","id":"compound-48-80","score":0.5874,"url":"https://openalex.org/keywords/compound-48-80"},{"display_name":"histamine H1 receptor antagonists","id":"histamine-h1-receptor-antagonists","score":0.2515,"url":"https://openalex.org/keywords/histamine-h1-receptor-antagonists"},{"display_name":"histamine H1 receptor","id":"histamine-h1-receptor","score":0.3019,"url":"https://openalex.org/keywords/histamine-h1-receptor"},{"display_name":"histamine receptors","id":"histamine-receptors","score":0.4385,"url":"https://openalex.org/keywords/histamine-receptors"},{"display_name":"peritoneal mast cells","id":"peritoneal-mast-cells","score":0.8581,"url":"https://openalex.org/keywords/peritoneal-mast-cells"},{"display_name":"cutaneous mastocytosis","id":"cutaneous-mastocytosis","score":0.8478,"url":"https://openalex.org/keywords/cutaneous-mastocytosis"},{"display_name":"histamine H2 receptor","id":"histamine-h2-receptor","score":0.351,"url":"https://openalex.org/keywords/histamine-h2-receptor"},{"display_name":"mast cell mediators","id":"mast-cell-mediators","score":0.6726,"url":"https://openalex.org/keywords/mast-cell-mediators"},{"display_name":"RBL-2H3 cells","id":"rbl-2h3-cells","score":0.4383,"url":"https://openalex.org/keywords/rbl-2h3-cells"},{"display_name":"passive cutaneous anaphylaxis","id":"passive-cutaneous-anaphylaxis","score":0.4293,"url":"https://openalex.org/keywords/passive-cutaneous-anaphylaxis"},{"display_name":"bone marrow-derived mast cells","id":"bone-marrow-derived-mast-cells","score":0.7764,"url":"https://openalex.org/keywords/bone-marrow-derived-mast-cells"},{"display_name":"urticaria pigmentosa","id":"urticaria-pigmentosa","score":0.6527,"url":"https://openalex.org/keywords/urticaria-pigmentosa"},{"display_name":"antiallergic drugs","id":"antiallergic-drugs","score":0.2069,"url":"https://openalex.org/keywords/antiallergic-drugs"},{"display_name":"mast cell granules","id":"mast-cell-granules","score":0.7454,"url":"https://openalex.org/keywords/mast-cell-granules"}],"legacy_keywords":["Mast Cells","Allergic Disease","Immune Responses","Histamine","Basophils","T Cell Activation","Inflammation","Cytokines","Receptor Tyrosine Kinase","Mastocytosis"],"openalex_id":"https://openalex.org/T11346","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T11346","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11346","works_count":67611,"label":"Mast cells and histamine","provider":"openalex","revision":"ff3e7c57107bbc3a","taxonomy_revision":"f050b5d4780b1289","title":"Mast cells and histamine","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248716730572997","address_version":"morton4x16-v1","coordinates":[1,24,2403,11346],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}