{"cited_by_count":915298,"description":"This cluster of papers focuses on the causes, molecular basis, detection, transmission, and potential treatments for prion diseases, including variant Creutzfeldt-Jakob disease. It explores the role of infectious prions, protein misfolding, and their impact on neurodegenerative diseases. The research also delves into the pathology of these diseases and their transmissibility through blood transfusion.","display_name":"Prion Diseases and Protein Misfolding","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11335","wikipedia":"https://en.wikipedia.org/wiki/Prion"},"field_id":"13","id":"T11335","keywords":[{"display_name":"prion disease","id":"prion-disease","score":0.8446,"url":"https://openalex.org/keywords/prion-disease"},{"display_name":"prion protein","id":"prion-protein","score":0.8237,"url":"https://openalex.org/keywords/prion-protein"},{"display_name":"Creutzfeldt-Jakob disease","id":"creutzfeldt-jakob-disease","score":0.7855,"url":"https://openalex.org/keywords/creutzfeldt-jakob-disease"},{"display_name":"bovine spongiform encephalopathy","id":"bovine-spongiform-encephalopathy","score":0.5237,"url":"https://openalex.org/keywords/bovine-spongiform-encephalopathy"},{"display_name":"scrapie","id":"scrapie","score":0.9273,"url":"https://openalex.org/keywords/scrapie"},{"display_name":"prions","id":"prions","score":0.7188,"url":"https://openalex.org/keywords/prions"},{"display_name":"variant Creutzfeldt-Jakob disease","id":"variant-creutzfeldt-jakob-disease","score":0.85,"url":"https://openalex.org/keywords/variant-creutzfeldt-jakob-disease"},{"display_name":"cellular prion protein","id":"cellular-prion-protein","score":0.7297,"url":"https://openalex.org/keywords/cellular-prion-protein"},{"display_name":"PrPSc","id":"prpsc","score":0.9768,"url":"https://openalex.org/keywords/prpsc"},{"display_name":"sporadic Creutzfeldt-Jakob disease","id":"sporadic-creutzfeldt-jakob-disease","score":0.9566,"url":"https://openalex.org/keywords/sporadic-creutzfeldt-jakob-disease"},{"display_name":"prion transmission","id":"prion-transmission","score":0.856,"url":"https://openalex.org/keywords/prion-transmission"},{"display_name":"chronic wasting disease","id":"chronic-wasting-disease","score":0.7012,"url":"https://openalex.org/keywords/chronic-wasting-disease"},{"display_name":"prion protein gene","id":"prnp","score":0.7793,"url":"https://openalex.org/keywords/prnp"},{"display_name":"prion strains","id":"prion-strains","score":0.9425,"url":"https://openalex.org/keywords/prion-strains"},{"display_name":"spongiform encephalopathy","id":"spongiform-encephalopathy","score":0.8202,"url":"https://openalex.org/keywords/spongiform-encephalopathy"},{"display_name":"prion propagation","id":"prion-propagation","score":0.8765,"url":"https://openalex.org/keywords/prion-propagation"},{"display_name":"Gerstmann-Str\u00e4ussler-Scheinker disease","id":"gerstmann-straussler-scheinker-disease","score":0.9318,"url":"https://openalex.org/keywords/gerstmann-straussler-scheinker-disease"},{"display_name":"prion detection","id":"prion-detection","score":0.9072,"url":"https://openalex.org/keywords/prion-detection"},{"display_name":"familial prion disease","id":"genetic-prion-disease","score":0.9717,"url":"https://openalex.org/keywords/genetic-prion-disease"},{"display_name":"kuru","id":"kuru","score":0.7429,"url":"https://openalex.org/keywords/kuru"},{"display_name":"prion pathogenesis","id":"prion-disease-pathogenesis","score":0.9855,"url":"https://openalex.org/keywords/prion-disease-pathogenesis"},{"display_name":"fatal familial insomnia","id":"fatal-familial-insomnia","score":0.864,"url":"https://openalex.org/keywords/fatal-familial-insomnia"},{"display_name":"prion conversion","id":"prion-conversion","score":0.953,"url":"https://openalex.org/keywords/prion-conversion"},{"display_name":"yeast prions","id":"yeast-prions","score":0.8242,"url":"https://openalex.org/keywords/yeast-prions"},{"display_name":"prion replication","id":"prion-replication","score":0.9642,"url":"https://openalex.org/keywords/prion-replication"}],"legacy_keywords":["Prion Diseases","Molecular Basis","Pathological Protein Misfolding","Variant Creutzfeldt-Jakob Disease","Infectious Prions","Neurodegenerative Diseases","Protein Aggregation","Transmissible Spongiform Encephalopathies","Cyclic Amplification","Cellular Prion Protein"],"openalex_id":"https://openalex.org/T11335","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T11335","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11335","works_count":43734,"label":"Prion Diseases and Protein Misfolding","provider":"openalex","revision":"dad528a21df95f44","taxonomy_revision":"f050b5d4780b1289","title":"Prion Diseases and Protein Misfolding","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36182745965144715","address_version":"morton4x16-v1","coordinates":[1,13,1312,11335],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}