{"cited_by_count":767804,"description":"This cluster of papers focuses on the pathogenesis, clinical manifestations, and treatment of systemic sclerosis, with an emphasis on fibrosis, autoantibodies, pulmonary involvement, and the role of TGF-\u00df signaling. It also explores genetic markers, endothelial dysfunction, and various treatment approaches including immunosuppressive therapy for this complex autoimmune disease.","display_name":"Systemic Sclerosis and Related Diseases","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11330","wikipedia":"https://en.wikipedia.org/wiki/Systemic_sclerosis"},"field_id":"27","id":"T11330","keywords":[{"display_name":"systemic sclerosis","id":"systemic-sclerosis","score":0.6298,"url":"https://openalex.org/keywords/systemic-sclerosis"},{"display_name":"Raynaud's phenomenon","id":"raynaud-s-phenomenon","score":0.5263,"url":"https://openalex.org/keywords/raynaud-s-phenomenon"},{"display_name":"diffuse cutaneous systemic sclerosis","id":"diffuse-cutaneous-systemic-sclerosis","score":0.9194,"url":"https://openalex.org/keywords/diffuse-cutaneous-systemic-sclerosis"},{"display_name":"skin fibrosis","id":"skin-fibrosis","score":0.4847,"url":"https://openalex.org/keywords/skin-fibrosis"},{"display_name":"limited cutaneous systemic sclerosis","id":"limited-cutaneous-systemic-sclerosis","score":0.8798,"url":"https://openalex.org/keywords/limited-cutaneous-systemic-sclerosis"},{"display_name":"morphea","id":"localized-scleroderma","score":0.66,"url":"https://openalex.org/keywords/localized-scleroderma"},{"display_name":"digital ulcers","id":"digital-ulcers","score":0.8585,"url":"https://openalex.org/keywords/digital-ulcers"},{"display_name":"mixed connective tissue disease","id":"mixed-connective-tissue-disease","score":0.3643,"url":"https://openalex.org/keywords/mixed-connective-tissue-disease"},{"display_name":"anti-centromere antibodies","id":"anticentromere-antibodies","score":0.7009,"url":"https://openalex.org/keywords/anticentromere-antibodies"},{"display_name":"anti-Scl-70 antibodies","id":"anti-scl-70-antibodies","score":0.7817,"url":"https://openalex.org/keywords/anti-scl-70-antibodies"},{"display_name":"nailfold capillaroscopy","id":"nailfold-capillaroscopy","score":0.5104,"url":"https://openalex.org/keywords/nailfold-capillaroscopy"},{"display_name":"modified Rodnan skin score","id":"modified-rodnan-skin-score","score":0.9472,"url":"https://openalex.org/keywords/modified-rodnan-skin-score"},{"display_name":"scleroderma renal crisis","id":"scleroderma-renal-crisis","score":0.8098,"url":"https://openalex.org/keywords/scleroderma-renal-crisis"},{"display_name":"vasculopathy","id":"vasculopathy","score":0.2886,"url":"https://openalex.org/keywords/vasculopathy"},{"display_name":"capillaroscopy","id":"capillaroscopy","score":0.3679,"url":"https://openalex.org/keywords/capillaroscopy"},{"display_name":"primary Raynaud's phenomenon","id":"primary-raynaud-s-phenomenon","score":0.8573,"url":"https://openalex.org/keywords/primary-raynaud-s-phenomenon"},{"display_name":"digital ischemia","id":"digital-ischemia","score":0.3514,"url":"https://openalex.org/keywords/digital-ischemia"},{"display_name":"nailfold videocapillaroscopy","id":"nailfold-videocapillaroscopy","score":0.6989,"url":"https://openalex.org/keywords/nailfold-videocapillaroscopy"},{"display_name":"Parry-Romberg syndrome","id":"parry-romberg-syndrome","score":0.6746,"url":"https://openalex.org/keywords/parry-romberg-syndrome"},{"display_name":"CREST syndrome","id":"crest-syndrome","score":0.5315,"url":"https://openalex.org/keywords/crest-syndrome"},{"display_name":"secondary Raynaud's phenomenon","id":"secondary-raynaud-phenomenon","score":0.8513,"url":"https://openalex.org/keywords/secondary-raynaud-phenomenon"},{"display_name":"sclerodactyly","id":"sclerodactyly","score":0.7044,"url":"https://openalex.org/keywords/sclerodactyly"},{"display_name":"linear scleroderma","id":"linear-scleroderma","score":0.7218,"url":"https://openalex.org/keywords/linear-scleroderma"},{"display_name":"skin thickening","id":"skin-thickening","score":0.274,"url":"https://openalex.org/keywords/skin-thickening"},{"display_name":"systemic sclerosis-associated interstitial lung disease","id":"systemic-sclerosis-associated-interstitial-lung-disease","score":0.7054,"url":"https://openalex.org/keywords/systemic-sclerosis-associated-interstitial-lung-disease"}],"legacy_keywords":["Systemic Sclerosis","Fibrosis","Autoantibodies","Pulmonary Involvement","Treatment","Raynaud's Phenomenon","Genetic Markers","Endothelial Dysfunction","TGF-\u00df Signaling","Immunosuppressive Therapy"],"openalex_id":"https://openalex.org/T11330","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2734","url":"/topics/T11330","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11330","works_count":58611,"label":"Systemic Sclerosis and Related Diseases","provider":"openalex","revision":"82da3d3c06a71cf7","taxonomy_revision":"f050b5d4780b1289","title":"Systemic Sclerosis and Related Diseases","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248975434737122","address_version":"morton4x16-v1","coordinates":[4,27,2734,11330],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}