{"cited_by_count":1810753,"description":"This cluster of papers explores the diverse aspects of macrophage activation and polarization, including their role in tumor microenvironments, interaction with myeloid-derived suppressor cells, modulation of immune responses, and metabolic regulation. The papers cover topics such as monocyte and macrophage heterogeneity, tissue-resident macrophages, and the impact of macrophage plasticity on health and disease.","display_name":"Immune cells in cancer","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11313","wikipedia":"https://en.wikipedia.org/wiki/Macrophage_activation_syndrome"},"field_id":"24","id":"T11313","keywords":[{"display_name":"tumor-associated macrophages","id":"tumor-associated-macrophages","score":0.4181,"url":"https://openalex.org/keywords/tumor-associated-macrophages"},{"display_name":"myeloid-derived suppressor cells","id":"myeloid-derived-suppressor-cells","score":0.3252,"url":"https://openalex.org/keywords/myeloid-derived-suppressor-cells"},{"display_name":"M2 macrophage polarization","id":"m2-macrophage-polarization","score":0.2348,"url":"https://openalex.org/keywords/m2-macrophage-polarization"},{"display_name":"tumor-associated neutrophils","id":"tumor-associated-neutrophils","score":0.3107,"url":"https://openalex.org/keywords/tumor-associated-neutrophils"},{"display_name":"macrophage heterogeneity","id":"macrophage-heterogeneity","score":0.3076,"url":"https://openalex.org/keywords/macrophage-heterogeneity"},{"display_name":"tumour-associated macrophages","id":"tumour-associated-macrophages","score":0.4152,"url":"https://openalex.org/keywords/tumour-associated-macrophages"},{"display_name":"macrophage plasticity","id":"macrophage-plasticity","score":0.4126,"url":"https://openalex.org/keywords/macrophage-plasticity"},{"display_name":"macrophage reprogramming","id":"macrophage-reprogramming","score":0.4013,"url":"https://openalex.org/keywords/macrophage-reprogramming"},{"display_name":"macrophage cytotoxicity","id":"macrophage-mediated-cytotoxicity","score":0.2729,"url":"https://openalex.org/keywords/macrophage-mediated-cytotoxicity"},{"display_name":"tissue-resident macrophages","id":"tissue-resident-macrophages","score":0.2235,"url":"https://openalex.org/keywords/tissue-resident-macrophages"},{"display_name":"monocytic MDSCs","id":"monocytic-mdscs","score":0.6279,"url":"https://openalex.org/keywords/monocytic-mdscs"},{"display_name":"macrophage metabolism","id":"macrophage-metabolism","score":0.3159,"url":"https://openalex.org/keywords/macrophage-metabolism"},{"display_name":"polymorphonuclear myeloid-derived suppressor cells","id":"pmn-mdscs","score":0.4475,"url":"https://openalex.org/keywords/pmn-mdscs"},{"display_name":"TAM-targeted therapy","id":"tam-targeted-therapy","score":0.9231,"url":"https://openalex.org/keywords/tam-targeted-therapy"},{"display_name":"granulocytic MDSCs","id":"granulocytic-mdscs","score":0.5865,"url":"https://openalex.org/keywords/granulocytic-mdscs"},{"display_name":"macrophage-targeted therapy","id":"macrophage-targeted-therapy","score":0.4036,"url":"https://openalex.org/keywords/macrophage-targeted-therapy"},{"display_name":"macrophage-tumor cell interaction","id":"tumor-cell-macrophage-interaction","score":0.6558,"url":"https://openalex.org/keywords/tumor-cell-macrophage-interaction"},{"display_name":"TAM polarization","id":"tam-polarization","score":0.6921,"url":"https://openalex.org/keywords/tam-polarization"},{"display_name":"tumor-associated myeloid cells","id":"tumor-associated-myeloid-cells","score":0.3623,"url":"https://openalex.org/keywords/tumor-associated-myeloid-cells"},{"display_name":"tumor-infiltrating myeloid cells","id":"tumor-infiltrating-myeloid-cells","score":0.2283,"url":"https://openalex.org/keywords/tumor-infiltrating-myeloid-cells"},{"display_name":"microbial signals","id":"microbial-signals","score":0.4945,"url":"https://openalex.org/keywords/microbial-signals"},{"display_name":"tumoricidal activity","id":"tumoricidal-activity","score":0.3499,"url":"https://openalex.org/keywords/tumoricidal-activity"},{"display_name":"tissue damage signals","id":"tissue-damage-signals","score":0.5685,"url":"https://openalex.org/keywords/tissue-damage-signals"},{"display_name":"macrophage origin","id":"macrophage-origin","score":0.3012,"url":"https://openalex.org/keywords/macrophage-origin"},{"display_name":"macrophage activating factor","id":"macrophage-activating-factor","score":0.3613,"url":"https://openalex.org/keywords/macrophage-activating-factor"}],"legacy_keywords":["Macrophage","Activation","Polarization","Tumor-associated","Monocytes","Myeloid-derived suppressor cells","Inflammation","Metabolism","Cancer","Immunity"],"openalex_id":"https://openalex.org/T11313","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T11313","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11313","works_count":52146,"label":"Immune cells in cancer","provider":"openalex","revision":"09d877eaaf7dadaa","taxonomy_revision":"f050b5d4780b1289","title":"Immune cells in cancer","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248716604743757","address_version":"morton4x16-v1","coordinates":[1,24,2403,11313],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}