{"cited_by_count":637890,"description":"This cluster of papers focuses on the mechanisms and implications of ferroptosis in cancer, exploring topics such as the role of lipid peroxidation, the involvement of GPX4, the impact on the tumor microenvironment, and the interplay with immune cells. It also covers the use of RNA-sequencing for gene expression analysis in the context of ferroptosis and cancer.","display_name":"Ferroptosis and cancer prognosis","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11297","wikipedia":"https://en.wikipedia.org/wiki/Ferroptosis"},"field_id":"27","id":"T11297","keywords":[{"display_name":"ferroptosis","id":"ferroptosis","score":0.4167,"url":"https://openalex.org/keywords/ferroptosis"},{"display_name":"GPX4","id":"gpx4","score":0.4153,"url":"https://openalex.org/keywords/gpx4"},{"display_name":"SLC7A11","id":"slc7a11","score":0.3778,"url":"https://openalex.org/keywords/slc7a11"},{"display_name":"cuproptosis","id":"cuproptosis","score":0.2988,"url":"https://openalex.org/keywords/cuproptosis"},{"display_name":"erastin","id":"erastin","score":0.5768,"url":"https://openalex.org/keywords/erastin"},{"display_name":"ACSL4","id":"acsl4","score":0.4089,"url":"https://openalex.org/keywords/acsl4"},{"display_name":"ferrostatin-1","id":"ferrostatin-1","score":0.4911,"url":"https://openalex.org/keywords/ferrostatin-1"},{"display_name":"ferroptosis resistance","id":"ferroptosis-resistance","score":0.7079,"url":"https://openalex.org/keywords/ferroptosis-resistance"},{"display_name":"ferroptosis-related genes","id":"ferroptosis-related-genes","score":0.7299,"url":"https://openalex.org/keywords/ferroptosis-related-genes"},{"display_name":"RSL3","id":"rsl3","score":0.6207,"url":"https://openalex.org/keywords/rsl3"},{"display_name":"regulated cell death","id":"regulated-cell-death","score":0.2573,"url":"https://openalex.org/keywords/regulated-cell-death"},{"display_name":"ferroptosis inhibitors","id":"ferroptosis-inhibitors","score":0.645,"url":"https://openalex.org/keywords/ferroptosis-inhibitors"},{"display_name":"ferroptosis inducers","id":"ferroptosis-inducers","score":0.8702,"url":"https://openalex.org/keywords/ferroptosis-inducers"},{"display_name":"ferritinophagy","id":"ferritinophagy","score":0.3892,"url":"https://openalex.org/keywords/ferritinophagy"},{"display_name":"disulfidptosis","id":"disulfidptosis","score":0.4567,"url":"https://openalex.org/keywords/disulfidptosis"},{"display_name":"iron-dependent cell death","id":"iron-dependent-cell-death","score":0.7419,"url":"https://openalex.org/keywords/iron-dependent-cell-death"},{"display_name":"FTH1","id":"fth1","score":0.2425,"url":"https://openalex.org/keywords/fth1"},{"display_name":"NCOA4","id":"ncoa4","score":0.3315,"url":"https://openalex.org/keywords/ncoa4"},{"display_name":"ferroptosis-targeted therapy","id":"ferroptosis-targeted-therapy","score":0.8915,"url":"https://openalex.org/keywords/ferroptosis-targeted-therapy"},{"display_name":"system xc-","id":"system-xc","score":0.2742,"url":"https://openalex.org/keywords/system-xc"},{"display_name":"lipid reactive oxygen species","id":"lipid-reactive-oxygen-species","score":0.6407,"url":"https://openalex.org/keywords/lipid-reactive-oxygen-species"},{"display_name":"FDX1","id":"fdx1","score":0.305,"url":"https://openalex.org/keywords/fdx1"},{"display_name":"cuproptosis-related genes","id":"cuproptosis-related-genes","score":0.5619,"url":"https://openalex.org/keywords/cuproptosis-related-genes"},{"display_name":"liproxstatin-1","id":"liproxstatin-1","score":0.4614,"url":"https://openalex.org/keywords/liproxstatin-1"},{"display_name":"Fer-1","id":"fer-1","score":0.4323,"url":"https://openalex.org/keywords/fer-1"}],"legacy_keywords":["Ferroptosis","Cancer","Cell Death","Tumor Microenvironment","Lipid Peroxidation","GPX4","Immune Cells","Oxidative Stress","RNA-sequencing","Gene Expression"],"openalex_id":"https://openalex.org/T11297","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2740","url":"/topics/T11297","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11297","works_count":23258,"label":"Ferroptosis and cancer prognosis","provider":"openalex","revision":"8c24dafc50f07fde","taxonomy_revision":"f050b5d4780b1289","title":"Ferroptosis and cancer prognosis","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248975309153578","address_version":"morton4x16-v1","coordinates":[4,27,2740,11297],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}