{"cited_by_count":673698,"description":"This cluster of papers focuses on the management and treatment of hemophilia, including prophylaxis, inhibitors, gene therapy, and the impact on joint health. It covers a wide range of topics such as recombinant factor VIII, factor IX, and the safety and efficacy of various treatment strategies.","display_name":"Hemophilia Treatment and Research","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11280","wikipedia":"https://en.wikipedia.org/wiki/Hemophilia_management"},"field_id":"27","id":"T11280","keywords":[{"display_name":"hemophilia A","id":"hemophilia-a","score":0.8639,"url":"https://openalex.org/keywords/hemophilia-a"},{"display_name":"hemophilia","id":"hemophilia","score":0.6484,"url":"https://openalex.org/keywords/hemophilia"},{"display_name":"hemophilia B","id":"hemophilia-b","score":0.8144,"url":"https://openalex.org/keywords/hemophilia-b"},{"display_name":"factor VIII","id":"factor-viii","score":0.4857,"url":"https://openalex.org/keywords/factor-viii"},{"display_name":"factor VIII inhibitors","id":"factor-viii-inhibitors","score":0.955,"url":"https://openalex.org/keywords/factor-viii-inhibitors"},{"display_name":"factor replacement therapy","id":"coagulation-factor-replacement-therapy","score":0.7469,"url":"https://openalex.org/keywords/coagulation-factor-replacement-therapy"},{"display_name":"bleeding disorders","id":"bleeding-disorders","score":0.2093,"url":"https://openalex.org/keywords/bleeding-disorders"},{"display_name":"recombinant factor VIIa","id":"recombinant-factor-viia","score":0.5056,"url":"https://openalex.org/keywords/recombinant-factor-viia"},{"display_name":"factor IX","id":"factor-ix","score":0.5705,"url":"https://openalex.org/keywords/factor-ix"},{"display_name":"hemarthrosis","id":"hemarthrosis","score":0.5973,"url":"https://openalex.org/keywords/hemarthrosis"},{"display_name":"hemophilic arthropathy","id":"hemophilic-arthropathy","score":0.8084,"url":"https://openalex.org/keywords/hemophilic-arthropathy"},{"display_name":"recombinant factor VIII","id":"recombinant-factor-viii","score":0.918,"url":"https://openalex.org/keywords/recombinant-factor-viii"},{"display_name":"von Willebrand disease","id":"von-willebrand-disease","score":0.2334,"url":"https://openalex.org/keywords/von-willebrand-disease"},{"display_name":"factor VIII concentrate","id":"factor-viii-concentrate","score":0.7953,"url":"https://openalex.org/keywords/factor-viii-concentrate"},{"display_name":"emicizumab","id":"emicizumab","score":0.958,"url":"https://openalex.org/keywords/emicizumab"},{"display_name":"hemophilia treatment","id":"hemophilia-treatment","score":0.9004,"url":"https://openalex.org/keywords/hemophilia-treatment"},{"display_name":"acquired hemophilia A","id":"acquired-hemophilia-a","score":0.9251,"url":"https://openalex.org/keywords/acquired-hemophilia-a"},{"display_name":"factor VIII replacement therapy","id":"factor-viii-replacement-therapy","score":0.9432,"url":"https://openalex.org/keywords/factor-viii-replacement-therapy"},{"display_name":"severe hemophilia","id":"severe-hemophilia","score":0.9671,"url":"https://openalex.org/keywords/severe-hemophilia"},{"display_name":"factor VII deficiency","id":"factor-vii-deficiency","score":0.6474,"url":"https://openalex.org/keywords/factor-vii-deficiency"},{"display_name":"acquired hemophilia","id":"acquired-hemophilia","score":0.8588,"url":"https://openalex.org/keywords/acquired-hemophilia"},{"display_name":"factor IX inhibitors","id":"factor-ix-inhibitors","score":0.9316,"url":"https://openalex.org/keywords/factor-ix-inhibitors"},{"display_name":"pediatric hemophilia","id":"pediatric-hemophilia","score":0.8958,"url":"https://openalex.org/keywords/pediatric-hemophilia"},{"display_name":"immune tolerance induction","id":"immune-tolerance-induction","score":0.5402,"url":"https://openalex.org/keywords/immune-tolerance-induction"},{"display_name":"on-demand treatment","id":"on-demand-treatment","score":0.5168,"url":"https://openalex.org/keywords/on-demand-treatment"}],"legacy_keywords":["Hemophilia","Factor VIII","Prophylaxis","Inhibitors","Recombinant Factor VIIa","Gene Therapy","Joint Disease","Coagulation Disorders","Efficacy","Safety"],"openalex_id":"https://openalex.org/T11280","source_created_date":"2024-01-23T15:27:10","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2720","url":"/topics/T11280","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11280","works_count":58555,"label":"Hemophilia Treatment and Research","provider":"openalex","revision":"1fbf422d77c647f5","taxonomy_revision":"f050b5d4780b1289","title":"Hemophilia Treatment and Research","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36248975301026082","address_version":"morton4x16-v1","coordinates":[4,27,2720,11280],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}