{"cited_by_count":496771,"description":"This cluster of papers focuses on the use of bisphosphonates in the treatment of bone metastases and associated complications, particularly osteonecrosis of the jaw. It explores the mechanisms of action, clinical features, and therapeutic opportunities for bisphosphonates in cancer treatment, with a specific emphasis on prostate and breast cancer. The papers also discuss the role of bisphosphonates in maintaining bone health and preventing skeletal complications in cancer patients.","display_name":"Bone health and treatments","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11221","wikipedia":"https://en.wikipedia.org/wiki/Bisphosphonate"},"field_id":"27","id":"T11221","keywords":[{"display_name":"bisphosphonates","id":"bisphosphonates","score":0.3552,"url":"https://openalex.org/keywords/bisphosphonates"},{"display_name":"zoledronic acid","id":"zoledronic-acid","score":0.4997,"url":"https://openalex.org/keywords/zoledronic-acid"},{"display_name":"osteonecrosis of the jaw","id":"osteonecrosis-of-the-jaw","score":0.7256,"url":"https://openalex.org/keywords/osteonecrosis-of-the-jaw"},{"display_name":"bisphosphonate-related osteonecrosis of the jaw","id":"bisphosphonate-related-osteonecrosis-of-the-jaw","score":0.912,"url":"https://openalex.org/keywords/bisphosphonate-related-osteonecrosis-of-the-jaw"},{"display_name":"denosumab","id":"denosumab","score":0.3082,"url":"https://openalex.org/keywords/denosumab"},{"display_name":"medication-related osteonecrosis of the jaw","id":"medication-related-osteonecrosis-of-the-jaw","score":0.884,"url":"https://openalex.org/keywords/medication-related-osteonecrosis-of-the-jaw"},{"display_name":"skeletal-related events","id":"skeletal-related-events","score":0.6429,"url":"https://openalex.org/keywords/skeletal-related-events"},{"display_name":"pamidronate","id":"pamidronate","score":0.4405,"url":"https://openalex.org/keywords/pamidronate"},{"display_name":"antiresorptive agents","id":"antiresorptive-agents","score":0.3399,"url":"https://openalex.org/keywords/antiresorptive-agents"},{"display_name":"ibandronate","id":"ibandronate","score":0.3904,"url":"https://openalex.org/keywords/ibandronate"},{"display_name":"antiresorptive therapy","id":"antiresorptive-therapy","score":0.2273,"url":"https://openalex.org/keywords/antiresorptive-therapy"},{"display_name":"clodronate","id":"clodronate","score":0.4375,"url":"https://openalex.org/keywords/clodronate"},{"display_name":"hypercalcemia of malignancy","id":"hypercalcemia-of-malignancy","score":0.3133,"url":"https://openalex.org/keywords/hypercalcemia-of-malignancy"},{"display_name":"intravenous bisphosphonates","id":"intravenous-bisphosphonates","score":0.5627,"url":"https://openalex.org/keywords/intravenous-bisphosphonates"},{"display_name":"oral bisphosphonates","id":"oral-bisphosphonates","score":0.4935,"url":"https://openalex.org/keywords/oral-bisphosphonates"},{"display_name":"breast cancer bone metastasis","id":"breast-cancer-bone-metastasis","score":0.2714,"url":"https://openalex.org/keywords/breast-cancer-bone-metastasis"},{"display_name":"bisphosphonate adverse effects","id":"bisphosphonate-adverse-effects","score":0.6219,"url":"https://openalex.org/keywords/bisphosphonate-adverse-effects"},{"display_name":"drug-induced bone disease","id":"drug-induced-bone-disease","score":0.4584,"url":"https://openalex.org/keywords/drug-induced-bone-disease"},{"display_name":"osteoclast inhibition","id":"osteoclast-inhibition","score":0.3303,"url":"https://openalex.org/keywords/osteoclast-inhibition"},{"display_name":"bone resorption inhibition","id":"bone-resorption-inhibition","score":0.3007,"url":"https://openalex.org/keywords/bone-resorption-inhibition"},{"display_name":"bisphosphonate therapy","id":"bisphosphonate-therapy","score":0.2225,"url":"https://openalex.org/keywords/bisphosphonate-therapy"},{"display_name":"nitrogen-containing bisphosphonates","id":"nitrogen-containing-bisphosphonates","score":0.5889,"url":"https://openalex.org/keywords/nitrogen-containing-bisphosphonates"},{"display_name":"RANKL inhibition","id":"rankl-inhibition","score":0.2293,"url":"https://openalex.org/keywords/rankl-inhibition"},{"display_name":"bone-modifying agents","id":"bone-modifying-agents","score":0.6799,"url":"https://openalex.org/keywords/bone-modifying-agents"},{"display_name":"osteolytic bone metastasis","id":"osteolytic-bone-metastasis","score":0.2543,"url":"https://openalex.org/keywords/osteolytic-bone-metastasis"}],"legacy_keywords":["Bisphosphonates","Osteonecrosis of the Jaw","Bone Metastasis","Cancer Treatment","Skeletal Complications","Mechanism of Action","Metastatic Bone Disease","Clinical Practice Guidelines","Prostate Cancer","Breast Cancer"],"openalex_id":"https://openalex.org/T11221","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T11221","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11221","works_count":34770,"label":"Bone health and treatments","provider":"openalex","revision":"60413f419f07bfe5","taxonomy_revision":"f050b5d4780b1289","title":"Bone health and treatments","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240765605276010","address_version":"morton4x16-v1","coordinates":[4,27,2730,11221],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}