{"cited_by_count":1332624,"description":"This cluster of papers focuses on the role of calcium signaling and ion channels, particularly TRP channels, in sensory neurons and their involvement in thermosensation, nociception, and the pain pathway. It also explores the function of store-operated channels, Orai1, and STIM1 in calcium homeostasis and signaling. The papers cover a wide range of topics related to calcium signaling in sensory perception and disease.","display_name":"Ion Channels and Receptors","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11204","wikipedia":"https://en.wikipedia.org/wiki/Calcium_signaling"},"field_id":"28","id":"T11204","keywords":[{"display_name":"TRPV1","id":"trpv1","score":0.4516,"url":"https://openalex.org/keywords/trpv1"},{"display_name":"TRP channels","id":"transient-receptor-potential-channels","score":0.5963,"url":"https://openalex.org/keywords/transient-receptor-potential-channels"},{"display_name":"store-operated calcium entry","id":"store-operated-calcium-entry","score":0.5261,"url":"https://openalex.org/keywords/store-operated-calcium-entry"},{"display_name":"TRPA1","id":"trpa1","score":0.5459,"url":"https://openalex.org/keywords/trpa1"},{"display_name":"STIM1","id":"stromal-interaction-molecule-1","score":0.6181,"url":"https://openalex.org/keywords/stromal-interaction-molecule-1"},{"display_name":"TRPV4","id":"trpv4","score":0.5003,"url":"https://openalex.org/keywords/trpv4"},{"display_name":"TRPM8","id":"trpm8","score":0.6558,"url":"https://openalex.org/keywords/trpm8"},{"display_name":"Orai1","id":"orai1","score":0.5969,"url":"https://openalex.org/keywords/orai1"},{"display_name":"acid-sensing ion channels","id":"acid-sensing-ion-channels","score":0.5017,"url":"https://openalex.org/keywords/acid-sensing-ion-channels"},{"display_name":"cation channels","id":"cation-channels","score":0.3304,"url":"https://openalex.org/keywords/cation-channels"},{"display_name":"thermosensation","id":"thermosensation","score":0.3195,"url":"https://openalex.org/keywords/thermosensation"},{"display_name":"TRPC1","id":"trpc1","score":0.6065,"url":"https://openalex.org/keywords/trpc1"},{"display_name":"TRPC6","id":"trpc6","score":0.3909,"url":"https://openalex.org/keywords/trpc6"},{"display_name":"TRPC channels","id":"trpc-channels","score":0.6495,"url":"https://openalex.org/keywords/trpc-channels"},{"display_name":"vanilloid receptor","id":"vanilloid-receptor","score":0.5968,"url":"https://openalex.org/keywords/vanilloid-receptor"},{"display_name":"TRPM2","id":"trpm2","score":0.4066,"url":"https://openalex.org/keywords/trpm2"},{"display_name":"TRPC3","id":"trpc3","score":0.5739,"url":"https://openalex.org/keywords/trpc3"},{"display_name":"TRPV2","id":"trpv2","score":0.6365,"url":"https://openalex.org/keywords/trpv2"},{"display_name":"CRAC channels","id":"crac-channels","score":0.6856,"url":"https://openalex.org/keywords/crac-channels"},{"display_name":"TRPM7","id":"trpm7","score":0.3843,"url":"https://openalex.org/keywords/trpm7"},{"display_name":"capsaicin receptor","id":"capsaicin-receptor","score":0.7306,"url":"https://openalex.org/keywords/capsaicin-receptor"},{"display_name":"TRPV3","id":"trpv3","score":0.703,"url":"https://openalex.org/keywords/trpv3"},{"display_name":"capsazepine","id":"capsazepine","score":0.457,"url":"https://openalex.org/keywords/capsazepine"},{"display_name":"TRPM4","id":"trpm4","score":0.5151,"url":"https://openalex.org/keywords/trpm4"},{"display_name":"TRPV1 antagonists","id":"trpv1-antagonists","score":0.6169,"url":"https://openalex.org/keywords/trpv1-antagonists"}],"legacy_keywords":["Calcium Signaling","Ion Channels","TRP Channels","Sensory Neurons","Thermosensation","Nociception","Store-Operated Channels","Orai1","STIM1","Pain Pathway"],"openalex_id":"https://openalex.org/T11204","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2809","url":"/topics/T11204","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11204","works_count":45696,"label":"Ion Channels and Receptors","provider":"openalex","revision":"7f731ba6c64e4cd0","taxonomy_revision":"f050b5d4780b1289","title":"Ion Channels and Receptors","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240765672122885","address_version":"morton4x16-v1","coordinates":[1,28,2809,11204],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}