{"cited_by_count":1292871,"description":"This cluster of papers focuses on the molecular physiology and pharmacology of purinergic signalling, including the role of adenosine receptors, P2X receptors, and nucleotide signalling in immune suppression, inflammation, neuroprotection, and the tumor microenvironment. It explores the potential therapeutic targets related to purinergic signalling.","display_name":"Adenosine and Purinergic Signaling","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11193","wikipedia":"https://en.wikipedia.org/wiki/Purinergic_signalling"},"field_id":"13","id":"T11193","keywords":[{"display_name":"adenosine","id":"adenosine","score":0.3044,"url":"https://openalex.org/keywords/adenosine"},{"display_name":"purinergic signaling","id":"purinergic-signaling","score":0.6492,"url":"https://openalex.org/keywords/purinergic-signaling"},{"display_name":"purinergic receptors","id":"purinergic-receptors","score":0.6762,"url":"https://openalex.org/keywords/purinergic-receptors"},{"display_name":"adenosine A1 receptor","id":"adenosine-a1-receptor","score":0.5629,"url":"https://openalex.org/keywords/adenosine-a1-receptor"},{"display_name":"adenosine receptors","id":"adenosine-receptors","score":0.5876,"url":"https://openalex.org/keywords/adenosine-receptors"},{"display_name":"P2X7 receptor","id":"p2x7-receptor","score":0.5554,"url":"https://openalex.org/keywords/p2x7-receptor"},{"display_name":"adenosine A2A receptor","id":"adenosine-a2a-receptor","score":0.4384,"url":"https://openalex.org/keywords/adenosine-a2a-receptor"},{"display_name":"extracellular ATP","id":"extracellular-atp","score":0.6064,"url":"https://openalex.org/keywords/extracellular-atp"},{"display_name":"P2X receptors","id":"p2x-receptors","score":0.7278,"url":"https://openalex.org/keywords/p2x-receptors"},{"display_name":"P2Y receptors","id":"p2y-receptors","score":0.7457,"url":"https://openalex.org/keywords/p2y-receptors"},{"display_name":"CD73","id":"cd73","score":0.4137,"url":"https://openalex.org/keywords/cd73"},{"display_name":"adenosine A2B receptor","id":"adenosine-a2b-receptor","score":0.6876,"url":"https://openalex.org/keywords/adenosine-a2b-receptor"},{"display_name":"ATP release","id":"atp-release","score":0.2883,"url":"https://openalex.org/keywords/atp-release"},{"display_name":"A3 adenosine receptor","id":"a3-adenosine-receptor","score":0.7152,"url":"https://openalex.org/keywords/a3-adenosine-receptor"},{"display_name":"P2Y2 receptor","id":"p2y2-receptor","score":0.7349,"url":"https://openalex.org/keywords/p2y2-receptor"},{"display_name":"adenosine receptor antagonists","id":"adenosine-receptor-antagonists","score":0.5959,"url":"https://openalex.org/keywords/adenosine-receptor-antagonists"},{"display_name":"CD39","id":"cd39","score":0.3723,"url":"https://openalex.org/keywords/cd39"},{"display_name":"ectonucleotidases","id":"ectonucleotidases","score":0.7354,"url":"https://openalex.org/keywords/ectonucleotidases"},{"display_name":"UTP","id":"uridine-triphosphate","score":0.4335,"url":"https://openalex.org/keywords/uridine-triphosphate"},{"display_name":"adenosine receptor agonists","id":"adenosine-receptor-agonists","score":0.6495,"url":"https://openalex.org/keywords/adenosine-receptor-agonists"},{"display_name":"P2Y1 receptor","id":"p2y1-receptor","score":0.582,"url":"https://openalex.org/keywords/p2y1-receptor"},{"display_name":"adenosine A2 receptor","id":"adenosine-a2-receptor","score":0.6993,"url":"https://openalex.org/keywords/adenosine-a2-receptor"},{"display_name":"ecto-5'-nucleotidase","id":"ecto-5-nucleotidase","score":0.6351,"url":"https://openalex.org/keywords/ecto-5-nucleotidase"},{"display_name":"suramin","id":"suramin","score":0.2391,"url":"https://openalex.org/keywords/suramin"},{"display_name":"extracellular nucleotides","id":"extracellular-nucleotides","score":0.7748,"url":"https://openalex.org/keywords/extracellular-nucleotides"}],"legacy_keywords":["Purinergic Signalling","Adenosine Receptors","P2X Receptors","Nucleotide Signalling","Immune Suppression","Inflammation","Neuroprotection","Extracellular ATP","Tumor Microenvironment","Therapeutic Targets"],"openalex_id":"https://openalex.org/T11193","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1314","url":"/topics/T11193","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11193","works_count":47593,"label":"Adenosine and Purinergic Signaling","provider":"openalex","revision":"9f9b82cd2f809fa3","taxonomy_revision":"f050b5d4780b1289","title":"Adenosine and Purinergic Signaling","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36174536009884235","address_version":"morton4x16-v1","coordinates":[1,13,1314,11193],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}