{"cited_by_count":2889074,"description":"This cluster of papers explores the structure, function, and signaling mechanisms of G protein-coupled receptors (GPCRs), with a focus on crystal structures, signal transduction, arrestin-mediated pathways, pharmacology, drug discovery, receptor activation, biased signaling, and the molecular mechanisms involved. The research covers a wide range of topics related to GPCRs and their implications in various biological processes.","display_name":"Receptor Mechanisms and Signaling","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11178","wikipedia":"https://en.wikipedia.org/wiki/G_protein-coupled_receptor"},"field_id":"13","id":"T11178","keywords":[{"display_name":"G protein-coupled receptors","id":"g-protein-coupled-receptors","score":0.3793,"url":"https://openalex.org/keywords/g-protein-coupled-receptors"},{"display_name":"beta-adrenergic receptors","id":"beta-adrenergic-receptors","score":0.2877,"url":"https://openalex.org/keywords/beta-adrenergic-receptors"},{"display_name":"muscarinic receptors","id":"muscarinic-receptors","score":0.2462,"url":"https://openalex.org/keywords/muscarinic-receptors"},{"display_name":"receptor desensitization","id":"receptor-desensitization","score":0.3506,"url":"https://openalex.org/keywords/receptor-desensitization"},{"display_name":"adenylate cyclase","id":"adenylate-cyclase","score":0.2183,"url":"https://openalex.org/keywords/adenylate-cyclase"},{"display_name":"beta2-adrenergic receptor","id":"beta2-adrenergic-receptor","score":0.3628,"url":"https://openalex.org/keywords/beta2-adrenergic-receptor"},{"display_name":"receptor internalization","id":"receptor-internalization","score":0.235,"url":"https://openalex.org/keywords/receptor-internalization"},{"display_name":"G proteins","id":"g-proteins","score":0.2767,"url":"https://openalex.org/keywords/g-proteins"},{"display_name":"alpha1-adrenoceptors","id":"alpha1-adrenergic-receptors","score":0.2739,"url":"https://openalex.org/keywords/alpha1-adrenergic-receptors"},{"display_name":"alpha2-adrenoceptors","id":"alpha2-adrenergic-receptors","score":0.2462,"url":"https://openalex.org/keywords/alpha2-adrenergic-receptors"},{"display_name":"G protein-coupled receptor signaling","id":"g-protein-coupled-receptor-signaling","score":0.3181,"url":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling"},{"display_name":"G protein signaling","id":"g-protein-signaling","score":0.2861,"url":"https://openalex.org/keywords/g-protein-signaling"},{"display_name":"receptor activation","id":"receptor-activation","score":0.2956,"url":"https://openalex.org/keywords/receptor-activation"},{"display_name":"adrenergic receptors","id":"adrenergic-receptors","score":0.3072,"url":"https://openalex.org/keywords/adrenergic-receptors"},{"display_name":"alpha-adrenergic receptors","id":"alpha-adrenergic-receptors","score":0.2517,"url":"https://openalex.org/keywords/alpha-adrenergic-receptors"},{"display_name":"beta1-adrenergic receptor","id":"beta1-adrenergic-receptor","score":0.3711,"url":"https://openalex.org/keywords/beta1-adrenergic-receptor"},{"display_name":"receptor structure","id":"receptor-structure","score":0.3336,"url":"https://openalex.org/keywords/receptor-structure"},{"display_name":"G protein coupling","id":"g-protein-coupling","score":0.5533,"url":"https://openalex.org/keywords/g-protein-coupling"},{"display_name":"heterotrimeric G proteins","id":"heterotrimeric-g-proteins","score":0.4207,"url":"https://openalex.org/keywords/heterotrimeric-g-proteins"},{"display_name":"M2 muscarinic receptor","id":"m2-muscarinic-receptor","score":0.4127,"url":"https://openalex.org/keywords/m2-muscarinic-receptor"},{"display_name":"receptor signaling","id":"receptor-signaling","score":0.2032,"url":"https://openalex.org/keywords/receptor-signaling"},{"display_name":"receptor phosphorylation","id":"receptor-phosphorylation","score":0.2918,"url":"https://openalex.org/keywords/receptor-phosphorylation"},{"display_name":"G protein alpha subunit","id":"g-protein-alpha-subunit","score":0.4262,"url":"https://openalex.org/keywords/g-protein-alpha-subunit"},{"display_name":"Gs protein","id":"gs-protein","score":0.4736,"url":"https://openalex.org/keywords/gs-protein"},{"display_name":"beta-arrestin","id":"beta-arrestin","score":0.547,"url":"https://openalex.org/keywords/beta-arrestin"}],"legacy_keywords":["Crystal Structure","G-Protein-Coupled Receptors","Signal Transduction","Arrestin","Pharmacology","Drug Discovery","Receptor Activation","Biased Signaling","Cell Signaling","Molecular Mechanisms"],"openalex_id":"https://openalex.org/T11178","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T11178","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11178","works_count":116704,"label":"Receptor Mechanisms and Signaling","provider":"openalex","revision":"1eb78fa43587f9a5","taxonomy_revision":"f050b5d4780b1289","title":"Receptor Mechanisms and Signaling","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36174536009360003","address_version":"morton4x16-v1","coordinates":[1,13,1312,11178],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}