{"cited_by_count":969382,"description":"This cluster of papers explores the genetics, regulation, and adaptive significance of melanin pigmentation in mammalian skin, including its role in UV damage protection, hormonal regulation, and conditions such as vitiligo. It covers a wide range of topics from the molecular mechanisms of melanogenesis to the evolutionary and adaptive aspects of skin coloration.","display_name":"melanin and skin pigmentation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11144","wikipedia":"https://en.wikipedia.org/wiki/Skin_pigmentation"},"field_id":"13","id":"T11144","keywords":[{"display_name":"vitiligo","id":"vitiligo","score":0.5707,"url":"https://openalex.org/keywords/vitiligo"},{"display_name":"melanogenesis","id":"melanin-synthesis","score":0.5768,"url":"https://openalex.org/keywords/melanin-synthesis"},{"display_name":"skin pigmentation","id":"skin-pigmentation","score":0.3302,"url":"https://openalex.org/keywords/skin-pigmentation"},{"display_name":"melanocytes","id":"melanocytes","score":0.4626,"url":"https://openalex.org/keywords/melanocytes"},{"display_name":"hyperpigmentation","id":"hyperpigmentation","score":0.2344,"url":"https://openalex.org/keywords/hyperpigmentation"},{"display_name":"melanin","id":"melanin","score":0.3433,"url":"https://openalex.org/keywords/melanin"},{"display_name":"skin lightening","id":"skin-lightening","score":0.273,"url":"https://openalex.org/keywords/skin-lightening"},{"display_name":"tyrosinase","id":"tyrosinase","score":0.3558,"url":"https://openalex.org/keywords/tyrosinase"},{"display_name":"skin pigmentation disorders","id":"pigmentary-disorders","score":0.4041,"url":"https://openalex.org/keywords/pigmentary-disorders"},{"display_name":"tyrosinase inhibition","id":"tyrosinase-inhibition","score":0.2526,"url":"https://openalex.org/keywords/tyrosinase-inhibition"},{"display_name":"repigmentation","id":"repigmentation","score":0.8251,"url":"https://openalex.org/keywords/repigmentation"},{"display_name":"skin whitening products","id":"skin-lightening-products","score":0.3393,"url":"https://openalex.org/keywords/skin-lightening-products"},{"display_name":"melasma","id":"melasma","score":0.226,"url":"https://openalex.org/keywords/melasma"},{"display_name":"melanogenesis inhibition","id":"melanogenesis-inhibition","score":0.5875,"url":"https://openalex.org/keywords/melanogenesis-inhibition"},{"display_name":"depigmentation","id":"depigmentation","score":0.5268,"url":"https://openalex.org/keywords/depigmentation"},{"display_name":"MITF","id":"mitf","score":0.37,"url":"https://openalex.org/keywords/mitf"},{"display_name":"herbal cosmetics","id":"herbal-cosmetics","score":0.2104,"url":"https://openalex.org/keywords/herbal-cosmetics"},{"display_name":"albinism","id":"albinism","score":0.275,"url":"https://openalex.org/keywords/albinism"},{"display_name":"melanosomes","id":"melanosomes","score":0.4647,"url":"https://openalex.org/keywords/melanosomes"},{"display_name":"skin bleaching creams","id":"skin-whitening-cream","score":0.2113,"url":"https://openalex.org/keywords/skin-whitening-cream"},{"display_name":"TRP-1","id":"trp-1","score":0.6173,"url":"https://openalex.org/keywords/trp-1"},{"display_name":"melanophores","id":"melanophores","score":0.5646,"url":"https://openalex.org/keywords/melanophores"},{"display_name":"hypopigmentation","id":"hypopigmentation","score":0.2956,"url":"https://openalex.org/keywords/hypopigmentation"},{"display_name":"pigmentation","id":"pigmentation","score":0.2199,"url":"https://openalex.org/keywords/pigmentation"},{"display_name":"eumelanin","id":"eumelanin","score":0.5994,"url":"https://openalex.org/keywords/eumelanin"}],"legacy_keywords":["Melanin","Pigmentation","Melanocyte","Regulation","Tyrosinase","UV Damage","Skin Color","Genetics","Vitiligo","Adaptation"],"openalex_id":"https://openalex.org/T11144","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T11144","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11144","works_count":72451,"label":"melanin and skin pigmentation","provider":"openalex","revision":"fdf651a0910c2da2","taxonomy_revision":"f050b5d4780b1289","title":"melanin and skin pigmentation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36174535997055559","address_version":"morton4x16-v1","coordinates":[1,13,1307,11144],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}