{"cited_by_count":1442190,"description":"This cluster of papers explores the role of extracellular matrix components such as hyaluronan, proteoglycans, and heparan sulfate in regulating cell signaling, synaptic plasticity, inflammation, and angiogenesis. It delves into the molecular interactions and functions of these matrix molecules in various biological processes.","display_name":"Proteoglycans and glycosaminoglycans research","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11131","wikipedia":"https://en.wikipedia.org/wiki/Extracellular_matrix"},"field_id":"13","id":"T11131","keywords":[{"display_name":"glycosaminoglycans","id":"glycosaminoglycans","score":0.3047,"url":"https://openalex.org/keywords/glycosaminoglycans"},{"display_name":"chondroitin sulfate","id":"chondroitin-sulfate","score":0.3847,"url":"https://openalex.org/keywords/chondroitin-sulfate"},{"display_name":"heparan sulfate","id":"heparan-sulfate","score":0.4302,"url":"https://openalex.org/keywords/heparan-sulfate"},{"display_name":"proteoglycans","id":"proteoglycans","score":0.3228,"url":"https://openalex.org/keywords/proteoglycans"},{"display_name":"hyaluronidase","id":"hyaluronidase","score":0.2456,"url":"https://openalex.org/keywords/hyaluronidase"},{"display_name":"heparan sulfate proteoglycans","id":"heparan-sulfate-proteoglycans","score":0.3759,"url":"https://openalex.org/keywords/heparan-sulfate-proteoglycans"},{"display_name":"dermatan sulfate","id":"dermatan-sulfate","score":0.5226,"url":"https://openalex.org/keywords/dermatan-sulfate"},{"display_name":"glycosaminoglycan synthesis","id":"glycosaminoglycan-biosynthesis","score":0.4784,"url":"https://openalex.org/keywords/glycosaminoglycan-biosynthesis"},{"display_name":"heparanase","id":"heparanase","score":0.4086,"url":"https://openalex.org/keywords/heparanase"},{"display_name":"chondroitin sulfate proteoglycans","id":"chondroitin-sulfate-proteoglycans","score":0.4004,"url":"https://openalex.org/keywords/chondroitin-sulfate-proteoglycans"},{"display_name":"keratan sulfate","id":"keratan-sulfate","score":0.4696,"url":"https://openalex.org/keywords/keratan-sulfate"},{"display_name":"proteoglycan synthesis","id":"proteoglycan-synthesis","score":0.3094,"url":"https://openalex.org/keywords/proteoglycan-synthesis"},{"display_name":"sulfated glycosaminoglycans","id":"sulfated-glycosaminoglycans","score":0.3344,"url":"https://openalex.org/keywords/sulfated-glycosaminoglycans"},{"display_name":"hyaluronan synthesis","id":"hyaluronan-synthesis","score":0.594,"url":"https://openalex.org/keywords/hyaluronan-synthesis"},{"display_name":"chondroitinase ABC","id":"chondroitinase-abc","score":0.4072,"url":"https://openalex.org/keywords/chondroitinase-abc"},{"display_name":"versican","id":"versican","score":0.2906,"url":"https://openalex.org/keywords/versican"},{"display_name":"hyaluronan synthase","id":"hyaluronan-synthase","score":0.604,"url":"https://openalex.org/keywords/hyaluronan-synthase"},{"display_name":"perlecan","id":"perlecan","score":0.3254,"url":"https://openalex.org/keywords/perlecan"},{"display_name":"biglycan","id":"biglycan","score":0.2863,"url":"https://openalex.org/keywords/biglycan"},{"display_name":"chondroitin 4-sulfate","id":"chondroitin-4-sulfate","score":0.5664,"url":"https://openalex.org/keywords/chondroitin-4-sulfate"},{"display_name":"HAS2","id":"hyaluronan-synthase-2","score":0.3729,"url":"https://openalex.org/keywords/hyaluronan-synthase-2"},{"display_name":"syndecan-4","id":"syndecan-4","score":0.319,"url":"https://openalex.org/keywords/syndecan-4"},{"display_name":"hyaluronan degradation","id":"hyaluronic-acid-degradation","score":0.5643,"url":"https://openalex.org/keywords/hyaluronic-acid-degradation"},{"display_name":"hyaluronan receptor","id":"hyaluronan-receptor","score":0.5371,"url":"https://openalex.org/keywords/hyaluronan-receptor"},{"display_name":"chondroitin-6-sulfate","id":"chondroitin-6-sulfate","score":0.4843,"url":"https://openalex.org/keywords/chondroitin-6-sulfate"}],"legacy_keywords":["Hyaluronan","Proteoglycans","Heparan Sulfate","CD44","Cell Signaling","Glycosaminoglycans","Toll-like Receptors","Synaptic Plasticity","Inflammation","Angiogenesis"],"openalex_id":"https://openalex.org/T11131","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T11131","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11131","works_count":52427,"label":"Proteoglycans and glycosaminoglycans research","provider":"openalex","revision":"236a32e30360ffc3","taxonomy_revision":"f050b5d4780b1289","title":"Proteoglycans and glycosaminoglycans research","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36174533992702671","address_version":"morton4x16-v1","coordinates":[1,13,1307,11131],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}