{"cited_by_count":1556525,"description":"This cluster of papers focuses on the pathophysiology, mechanisms, and therapeutic strategies related to myocardial reperfusion injury, including ischemic preconditioning, remote ischemic conditioning, oxidative stress, and the role of mitochondrial permeability transition pore. It also explores the involvement of various cell signaling pathways and reactive oxygen species in the context of cardioprotection and myocardial infarction.","display_name":"Cardiac Ischemia and Reperfusion","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11057","wikipedia":"https://en.wikipedia.org/wiki/Myocardial_reperfusion_injury"},"field_id":"27","id":"T11057","keywords":[{"display_name":"cardioprotection","id":"cardioprotection","score":0.3505,"url":"https://openalex.org/keywords/cardioprotection"},{"display_name":"myocardial ischemia-reperfusion injury","id":"myocardial-ischemia-reperfusion-injury","score":0.728,"url":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury"},{"display_name":"myocardial ischemia","id":"myocardial-ischemia","score":0.2189,"url":"https://openalex.org/keywords/myocardial-ischemia"},{"display_name":"ischemia-reperfusion 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apoptosis","id":"cardiomyocyte-apoptosis","score":0.2474,"url":"https://openalex.org/keywords/cardiomyocyte-apoptosis"},{"display_name":"coronary artery ligation","id":"coronary-artery-ligation","score":0.3105,"url":"https://openalex.org/keywords/coronary-artery-ligation"},{"display_name":"isolated perfused heart","id":"langendorff-preparation","score":0.3842,"url":"https://openalex.org/keywords/langendorff-preparation"},{"display_name":"myocardial energy metabolism","id":"myocardial-energy-metabolism","score":0.2553,"url":"https://openalex.org/keywords/myocardial-energy-metabolism"},{"display_name":"myocardial reperfusion","id":"myocardial-reperfusion","score":0.2658,"url":"https://openalex.org/keywords/myocardial-reperfusion"},{"display_name":"H9c2 cells","id":"h9c2-cells","score":0.2032,"url":"https://openalex.org/keywords/h9c2-cells"},{"display_name":"hypoxia/reoxygenation injury","id":"hypoxia-reoxygenation-injury","score":0.3959,"url":"https://openalex.org/keywords/hypoxia-reoxygenation-injury"},{"display_name":"ischemic postconditioning","id":"ischemic-postconditioning","score":0.7268,"url":"https://openalex.org/keywords/ischemic-postconditioning"},{"display_name":"cardioplegia","id":"cardioplegia","score":0.2714,"url":"https://openalex.org/keywords/cardioplegia"},{"display_name":"remote ischemic preconditioning","id":"remote-ischemic-preconditioning","score":0.5774,"url":"https://openalex.org/keywords/remote-ischemic-preconditioning"},{"display_name":"postconditioning","id":"postconditioning","score":0.6569,"url":"https://openalex.org/keywords/postconditioning"},{"display_name":"myocardial preconditioning","id":"myocardial-preconditioning","score":0.831,"url":"https://openalex.org/keywords/myocardial-preconditioning"},{"display_name":"reperfusion arrhythmias","id":"reperfusion-arrhythmias","score":0.6137,"url":"https://openalex.org/keywords/reperfusion-arrhythmias"},{"display_name":"isolated rat heart","id":"isolated-rat-heart","score":0.5512,"url":"https://openalex.org/keywords/isolated-rat-heart"},{"display_name":"hypoxia/reoxygenation","id":"hypoxia-reoxygenation","score":0.2687,"url":"https://openalex.org/keywords/hypoxia-reoxygenation"},{"display_name":"acute myocardial ischemia","id":"acute-myocardial-ischemia","score":0.2667,"url":"https://openalex.org/keywords/acute-myocardial-ischemia"}],"legacy_keywords":["Ischemia-Reperfusion Injury","Cardioprotection","Mitochondrial Permeability Transition Pore","Oxidative Stress","Ischemic Preconditioning","Remote Ischemic Conditioning","Reactive Oxygen Species","Myocardial Infarction","ATP-Sensitive Potassium Channels","Cell Signaling Pathways"],"openalex_id":"https://openalex.org/T11057","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2734","url":"/topics/T11057","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11057","works_count":87773,"label":"Cardiac Ischemia and Reperfusion","provider":"openalex","revision":"65738afc992d4db9","taxonomy_revision":"f050b5d4780b1289","title":"Cardiac Ischemia and Reperfusion","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240763331962218","address_version":"morton4x16-v1","coordinates":[4,27,2734,11057],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}