{"cited_by_count":955368,"description":"This cluster of papers explores the role of sirtuins, particularly SIRT1-7, in regulating metabolism, aging, and cellular homeostasis. It investigates the impact of resveratrol, NAD+, calorie restriction, and oxidative stress on sirtuin activity and their implications for longevity and age-related diseases. The cluster also delves into the interplay between sirtuins, mitochondria, and cellular energy balance.","display_name":"Sirtuins and Resveratrol in Medicine","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11051","wikipedia":"https://en.wikipedia.org/wiki/Sirtuin"},"field_id":"27","id":"T11051","keywords":[{"display_name":"resveratrol","id":"resveratrol","score":0.2534,"url":"https://openalex.org/keywords/resveratrol"},{"display_name":"SIRT1","id":"sirt1","score":0.2684,"url":"https://openalex.org/keywords/sirt1"},{"display_name":"sirtuins","id":"sirtuins","score":0.5602,"url":"https://openalex.org/keywords/sirtuins"},{"display_name":"SIRT3","id":"sirt3","score":0.3617,"url":"https://openalex.org/keywords/sirt3"},{"display_name":"NAD+-dependent deacetylase","id":"nad-dependent-deacetylase","score":0.7004,"url":"https://openalex.org/keywords/nad-dependent-deacetylase"},{"display_name":"SIRT6","id":"sirt6","score":0.4439,"url":"https://openalex.org/keywords/sirt6"},{"display_name":"NAD+ metabolism","id":"nad-metabolism","score":0.3502,"url":"https://openalex.org/keywords/nad-metabolism"},{"display_name":"SIRT2","id":"sirt2","score":0.3803,"url":"https://openalex.org/keywords/sirt2"},{"display_name":"NAD biosynthesis","id":"nad-biosynthesis","score":0.2903,"url":"https://openalex.org/keywords/nad-biosynthesis"},{"display_name":"nicotinamide mononucleotide","id":"nicotinamide-mononucleotide","score":0.3088,"url":"https://openalex.org/keywords/nicotinamide-mononucleotide"},{"display_name":"nicotinamide riboside","id":"nicotinamide-riboside","score":0.4078,"url":"https://openalex.org/keywords/nicotinamide-riboside"},{"display_name":"NAD+ precursors","id":"nad-precursors","score":0.4886,"url":"https://openalex.org/keywords/nad-precursors"},{"display_name":"SIRT5","id":"sirt5","score":0.4744,"url":"https://openalex.org/keywords/sirt5"},{"display_name":"protein deacetylation","id":"protein-deacetylation","score":0.364,"url":"https://openalex.org/keywords/protein-deacetylation"},{"display_name":"SIRT7","id":"sirt7","score":0.4789,"url":"https://openalex.org/keywords/sirt7"},{"display_name":"NAD+ salvage pathway","id":"nad-salvage-pathway","score":0.3878,"url":"https://openalex.org/keywords/nad-salvage-pathway"},{"display_name":"SIRT4","id":"sirt4","score":0.5454,"url":"https://openalex.org/keywords/sirt4"},{"display_name":"Sir2","id":"sir2","score":0.2724,"url":"https://openalex.org/keywords/sir2"},{"display_name":"resveratrol analogues","id":"resveratrol-analogs","score":0.3863,"url":"https://openalex.org/keywords/resveratrol-analogs"},{"display_name":"sirtuin inhibitors","id":"sirtuin-inhibitors","score":0.5977,"url":"https://openalex.org/keywords/sirtuin-inhibitors"},{"display_name":"resveratrol derivatives","id":"resveratrol-derivatives","score":0.3385,"url":"https://openalex.org/keywords/resveratrol-derivatives"},{"display_name":"SIRT1 activators","id":"sirt1-activators","score":0.6176,"url":"https://openalex.org/keywords/sirt1-activators"},{"display_name":"EX527","id":"ex527","score":0.2422,"url":"https://openalex.org/keywords/ex527"},{"display_name":"NAMPT inhibitors","id":"nampt-inhibitors","score":0.4227,"url":"https://openalex.org/keywords/nampt-inhibitors"},{"display_name":"SRT1720","id":"srt1720","score":0.4282,"url":"https://openalex.org/keywords/srt1720"}],"legacy_keywords":["Sirtuins","Resveratrol","Metabolism","Aging","Mitochondria","NAD+","Calorie Restriction","Oxidative Stress","Longevity","Cellular Homeostasis"],"openalex_id":"https://openalex.org/T11051","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2717","url":"/topics/T11051","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11051","works_count":26934,"label":"Sirtuins and Resveratrol in Medicine","provider":"openalex","revision":"44acc43469529954","taxonomy_revision":"f050b5d4780b1289","title":"Sirtuins and Resveratrol in Medicine","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240763327538606","address_version":"morton4x16-v1","coordinates":[4,27,2717,11051],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}