{"cited_by_count":854208,"description":"This cluster of papers focuses on the pharmacokinetics of antibiotics, particularly in critically ill patients. It covers topics such as drug dosing, antimicrobial resistance, therapeutic drug monitoring, and the impact of factors like augmented renal clearance on antibiotic levels in the body.","display_name":"Antibiotics Pharmacokinetics and Efficacy","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T11036","wikipedia":"https://en.wikipedia.org/wiki/Antibiotic_resistance"},"field_id":"27","id":"T11036","keywords":[{"display_name":"cephalosporins","id":"cephalosporins","score":0.2528,"url":"https://openalex.org/keywords/cephalosporins"},{"display_name":"aminoglycosides","id":"aminoglycosides","score":0.2186,"url":"https://openalex.org/keywords/aminoglycosides"},{"display_name":"serum drug concentration","id":"serum-drug-levels","score":0.2558,"url":"https://openalex.org/keywords/serum-drug-levels"},{"display_name":"antibiotic dosing","id":"antibiotic-dosing","score":0.553,"url":"https://openalex.org/keywords/antibiotic-dosing"},{"display_name":"carbapenems","id":"carbapenems","score":0.2055,"url":"https://openalex.org/keywords/carbapenems"},{"display_name":"trough concentration","id":"trough-concentration","score":0.2193,"url":"https://openalex.org/keywords/trough-concentration"},{"display_name":"antibiotic pharmacokinetics","id":"antibiotic-pharmacokinetics","score":0.6327,"url":"https://openalex.org/keywords/antibiotic-pharmacokinetics"},{"display_name":"piperacillin","id":"piperacillin","score":0.2578,"url":"https://openalex.org/keywords/piperacillin"},{"display_name":"population pharmacokinetic model","id":"population-pharmacokinetic-model","score":0.202,"url":"https://openalex.org/keywords/population-pharmacokinetic-model"},{"display_name":"tissue penetration","id":"tissue-penetration","score":0.3101,"url":"https://openalex.org/keywords/tissue-penetration"},{"display_name":"loading dose","id":"loading-dose","score":0.2022,"url":"https://openalex.org/keywords/loading-dose"},{"display_name":"time above MIC","id":"time-above-mic","score":0.8592,"url":"https://openalex.org/keywords/time-above-mic"},{"display_name":"probability of target attainment","id":"probability-of-target-attainment","score":0.8148,"url":"https://openalex.org/keywords/probability-of-target-attainment"},{"display_name":"pediatric antibiotic therapy","id":"pediatric-antibiotic-therapy","score":0.5426,"url":"https://openalex.org/keywords/pediatric-antibiotic-therapy"},{"display_name":"dosing interval","id":"dosing-interval","score":0.2058,"url":"https://openalex.org/keywords/dosing-interval"},{"display_name":"Gram-positive bacterial infections","id":"gram-positive-bacterial-infections","score":0.2103,"url":"https://openalex.org/keywords/gram-positive-bacterial-infections"},{"display_name":"pharmacokinetics/pharmacodynamics","id":"pharmacokinetics-pharmacodynamics","score":0.2259,"url":"https://openalex.org/keywords/pharmacokinetics-pharmacodynamics"},{"display_name":"antibiotic dosing regimens","id":"antibiotic-dosing-regimens","score":0.5184,"url":"https://openalex.org/keywords/antibiotic-dosing-regimens"},{"display_name":"AUC/MIC ratio","id":"auc-mic-ratio","score":0.7236,"url":"https://openalex.org/keywords/auc-mic-ratio"},{"display_name":"cefoperazone","id":"cefoperazone","score":0.2437,"url":"https://openalex.org/keywords/cefoperazone"},{"display_name":"prolonged infusion","id":"prolonged-infusion","score":0.3963,"url":"https://openalex.org/keywords/prolonged-infusion"},{"display_name":"post-antibiotic effect","id":"postantibiotic-effect","score":0.4143,"url":"https://openalex.org/keywords/postantibiotic-effect"},{"display_name":"netilmicin","id":"netilmicin","score":0.2824,"url":"https://openalex.org/keywords/netilmicin"},{"display_name":"imipenem/cilastatin","id":"imipenem-cilastatin","score":0.2568,"url":"https://openalex.org/keywords/imipenem-cilastatin"},{"display_name":"oral cephalosporins","id":"oral-cephalosporins","score":0.4843,"url":"https://openalex.org/keywords/oral-cephalosporins"}],"legacy_keywords":["Antibiotic Pharmacokinetics","Critically Ill Patients","Pharmacodynamic","Beta-lactam Antibiotics","Drug Dosing","Antimicrobial Resistance","Continuous Infusion","Aminoglycosides","Therapeutic Drug Monitoring","Augmented Renal Clearance"],"openalex_id":"https://openalex.org/T11036","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2736","url":"/topics/T11036","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11036","works_count":88882,"label":"Antibiotics Pharmacokinetics and Efficacy","provider":"openalex","revision":"b95f57a9724ff070","taxonomy_revision":"f050b5d4780b1289","title":"Antibiotics Pharmacokinetics and Efficacy","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240763323853090","address_version":"morton4x16-v1","coordinates":[4,27,2736,11036],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}