{"cited_by_count":1415089,"description":"This cluster of papers explores the role of natural killer (NK) cells in immunity, including their recognition mechanisms, activation, education, development, and potential for therapy. It covers topics such as NK cell receptors, immune inhibitory receptors, NKG2D immunoreceptor, and the use of NK cells in immunotherapy.","display_name":"Immune Cell Function and Interaction","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T11020","wikipedia":"https://en.wikipedia.org/wiki/Natural_killer_cell"},"field_id":"24","id":"T11020","keywords":[{"display_name":"natural killer cells","id":"natural-killer-cells","score":0.3279,"url":"https://openalex.org/keywords/natural-killer-cells"},{"display_name":"NK cell cytotoxicity","id":"nk-cell-cytotoxicity","score":0.4685,"url":"https://openalex.org/keywords/nk-cell-cytotoxicity"},{"display_name":"NK cell activation","id":"nk-cell-activation","score":0.6458,"url":"https://openalex.org/keywords/nk-cell-activation"},{"display_name":"NKG2D","id":"nkg2d","score":0.6001,"url":"https://openalex.org/keywords/nkg2d"},{"display_name":"killer cell immunoglobulin-like receptors","id":"killer-cell-immunoglobulin-like-receptors","score":0.6646,"url":"https://openalex.org/keywords/killer-cell-immunoglobulin-like-receptors"},{"display_name":"NK cell receptors","id":"nk-cell-receptors","score":0.7479,"url":"https://openalex.org/keywords/nk-cell-receptors"},{"display_name":"NK cell therapy","id":"nk-cell-therapy","score":0.7126,"url":"https://openalex.org/keywords/nk-cell-therapy"},{"display_name":"lymphokine-activated killer cells","id":"lymphokine-activated-killer-cells","score":0.407,"url":"https://openalex.org/keywords/lymphokine-activated-killer-cells"},{"display_name":"perforin","id":"perforin","score":0.204,"url":"https://openalex.org/keywords/perforin"},{"display_name":"inhibitory receptors","id":"inhibitory-receptors","score":0.374,"url":"https://openalex.org/keywords/inhibitory-receptors"},{"display_name":"CD16","id":"cd16","score":0.2683,"url":"https://openalex.org/keywords/cd16"},{"display_name":"NKG2D ligands","id":"nkg2d-ligands","score":0.6392,"url":"https://openalex.org/keywords/nkg2d-ligands"},{"display_name":"NK cell expansion","id":"nk-cell-expansion","score":0.7798,"url":"https://openalex.org/keywords/nk-cell-expansion"},{"display_name":"NKp46","id":"nkp46","score":0.6272,"url":"https://openalex.org/keywords/nkp46"},{"display_name":"NK cell subsets","id":"nk-cell-subsets","score":0.7205,"url":"https://openalex.org/keywords/nk-cell-subsets"},{"display_name":"NK cell differentiation","id":"nk-cell-differentiation","score":0.706,"url":"https://openalex.org/keywords/nk-cell-differentiation"},{"display_name":"NKG2A","id":"nkg2a","score":0.652,"url":"https://openalex.org/keywords/nkg2a"},{"display_name":"NK cell degranulation","id":"nk-cell-degranulation","score":0.6684,"url":"https://openalex.org/keywords/nk-cell-degranulation"},{"display_name":"NK cell proliferation","id":"nk-cell-proliferation","score":0.7243,"url":"https://openalex.org/keywords/nk-cell-proliferation"},{"display_name":"NK cell function","id":"nk-cell-function","score":0.6189,"url":"https://openalex.org/keywords/nk-cell-function"},{"display_name":"NK cell development","id":"nk-cell-development","score":0.7828,"url":"https://openalex.org/keywords/nk-cell-development"},{"display_name":"large granular lymphocytes","id":"large-granular-lymphocytes","score":0.4713,"url":"https://openalex.org/keywords/large-granular-lymphocytes"},{"display_name":"NKp30","id":"nkp30","score":0.7347,"url":"https://openalex.org/keywords/nkp30"},{"display_name":"HLA-E","id":"hla-e","score":0.3461,"url":"https://openalex.org/keywords/hla-e"},{"display_name":"NK cell dysfunction","id":"nk-cell-dysfunction","score":0.509,"url":"https://openalex.org/keywords/nk-cell-dysfunction"}],"legacy_keywords":["Natural Killer Cells","NK Cell Recognition","Immune Inhibitory Receptors","NKG2D Immunoreceptor","NK Cell Activation","NK Cell Education","NK Cell Therapy","NK Cell Receptors","NK Cell Development","NK Cell Immunotherapy"],"openalex_id":"https://openalex.org/T11020","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T11020","works_api_url":"https://api.openalex.org/works?filter=topics.id:T11020","works_count":51922,"label":"Immune Cell Function and Interaction","provider":"openalex","revision":"a028505cca2d63eb","taxonomy_revision":"f050b5d4780b1289","title":"Immune Cell Function and Interaction","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240504618395717","address_version":"morton4x16-v1","coordinates":[1,24,2403,11020],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}