{"cited_by_count":1393059,"description":"This cluster of papers explores the role of the complement system in immune response, focusing on its involvement in thrombotic microangiopathies, hemolytic uremic syndrome, and inflammatory diseases. It delves into the genetics, regulation, and therapeutic interventions such as Eculizumab for managing complement-related disorders.","display_name":"Complement system in diseases","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10993","wikipedia":"https://en.wikipedia.org/wiki/Complement_system"},"field_id":"24","id":"T10993","keywords":[{"display_name":"complement system","id":"complement-system","score":0.3722,"url":"https://openalex.org/keywords/complement-system"},{"display_name":"complement activation","id":"complement-activation","score":0.376,"url":"https://openalex.org/keywords/complement-activation"},{"display_name":"thrombotic thrombocytopenic purpura","id":"thrombotic-thrombocytopenic-purpura","score":0.7449,"url":"https://openalex.org/keywords/thrombotic-thrombocytopenic-purpura"},{"display_name":"thrombotic microangiopathy","id":"thrombotic-microangiopathy","score":0.5699,"url":"https://openalex.org/keywords/thrombotic-microangiopathy"},{"display_name":"alternative complement pathway","id":"alternative-complement-pathway","score":0.6353,"url":"https://openalex.org/keywords/alternative-complement-pathway"},{"display_name":"hemolytic uremic syndrome","id":"hemolytic-uremic-syndrome","score":0.4322,"url":"https://openalex.org/keywords/hemolytic-uremic-syndrome"},{"display_name":"paroxysmal nocturnal hemoglobinuria","id":"paroxysmal-nocturnal-hemoglobinuria","score":0.566,"url":"https://openalex.org/keywords/paroxysmal-nocturnal-hemoglobinuria"},{"display_name":"complement C3","id":"complement-c3","score":0.2445,"url":"https://openalex.org/keywords/complement-c3"},{"display_name":"eculizumab","id":"eculizumab","score":0.6755,"url":"https://openalex.org/keywords/eculizumab"},{"display_name":"atypical hemolytic uremic syndrome","id":"atypical-hemolytic-uremic-syndrome","score":0.8866,"url":"https://openalex.org/keywords/atypical-hemolytic-uremic-syndrome"},{"display_name":"complement inhibition","id":"complement-inhibition","score":0.5539,"url":"https://openalex.org/keywords/complement-inhibition"},{"display_name":"complement regulation","id":"complement-regulation","score":0.7383,"url":"https://openalex.org/keywords/complement-regulation"},{"display_name":"microangiopathic hemolytic anemia","id":"microangiopathic-hemolytic-anemia","score":0.7258,"url":"https://openalex.org/keywords/microangiopathic-hemolytic-anemia"},{"display_name":"complement factor H","id":"complement-factor-h","score":0.5155,"url":"https://openalex.org/keywords/complement-factor-h"},{"display_name":"membrane attack complex","id":"membrane-attack-complex","score":0.5377,"url":"https://openalex.org/keywords/membrane-attack-complex"},{"display_name":"classical complement pathway","id":"classical-complement-pathway","score":0.5773,"url":"https://openalex.org/keywords/classical-complement-pathway"},{"display_name":"C1q","id":"c1q","score":0.3745,"url":"https://openalex.org/keywords/c1q"},{"display_name":"complement regulatory proteins","id":"complement-regulatory-proteins","score":0.5973,"url":"https://openalex.org/keywords/complement-regulatory-proteins"},{"display_name":"ADAMTS13","id":"adamts13","score":0.4828,"url":"https://openalex.org/keywords/adamts13"},{"display_name":"C5a","id":"c5a","score":0.3082,"url":"https://openalex.org/keywords/c5a"},{"display_name":"mannose-binding lectin","id":"mannose-binding-lectin","score":0.3331,"url":"https://openalex.org/keywords/mannose-binding-lectin"},{"display_name":"factor B","id":"factor-b","score":0.6046,"url":"https://openalex.org/keywords/factor-b"},{"display_name":"CD55","id":"cd55","score":0.4227,"url":"https://openalex.org/keywords/cd55"},{"display_name":"CD59","id":"cd59","score":0.4531,"url":"https://openalex.org/keywords/cd59"},{"display_name":"properdin","id":"properdin","score":0.6734,"url":"https://openalex.org/keywords/properdin"}],"legacy_keywords":["Complement","Immune","Thrombotic Microangiopathies","Hemolytic Uremic Syndrome","Eculizumab","Innate Immunity","ADAMTS13","Regulation","Inflammatory Diseases","Genetics"],"openalex_id":"https://openalex.org/T10993","source_created_date":"2024-01-23T15:27:09","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T10993","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10993","works_count":73494,"label":"Complement system in diseases","provider":"openalex","revision":"df84063b2adeb8f9","taxonomy_revision":"f050b5d4780b1289","title":"Complement system in diseases","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240472549236813","address_version":"morton4x16-v1","coordinates":[1,24,2403,10993],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}