{"cited_by_count":935792,"description":"This cluster of papers explores the advancements in focused ultrasound technology and its diverse applications, including blood-brain barrier disruption, hyperthermia in cancer treatment, microbubble-mediated drug delivery, MRI-guided therapies, and noninvasive treatments for various conditions. The research covers a wide range of topics such as the use of ultrasound contrast agents, thermal therapy, and targeted drug delivery to the brain.","display_name":"Ultrasound and Hyperthermia Applications","domain_id":"3","external_ids":{"openalex":"https://openalex.org/T10958","wikipedia":"https://en.wikipedia.org/wiki/Focused_ultrasound"},"field_id":"22","id":"T10958","keywords":[{"display_name":"microbubbles","id":"microbubbles","score":0.4229,"url":"https://openalex.org/keywords/microbubbles"},{"display_name":"high-intensity focused ultrasound","id":"high-intensity-focused-ultrasound","score":0.5805,"url":"https://openalex.org/keywords/high-intensity-focused-ultrasound"},{"display_name":"ultrasound contrast agents","id":"ultrasound-contrast-agents","score":0.5822,"url":"https://openalex.org/keywords/ultrasound-contrast-agents"},{"display_name":"focused ultrasound","id":"focused-ultrasound","score":0.5985,"url":"https://openalex.org/keywords/focused-ultrasound"},{"display_name":"ultrasound therapy","id":"therapeutic-ultrasound","score":0.2753,"url":"https://openalex.org/keywords/therapeutic-ultrasound"},{"display_name":"thermal ablation","id":"thermal-ablation","score":0.2468,"url":"https://openalex.org/keywords/thermal-ablation"},{"display_name":"ultrasound-mediated drug delivery","id":"ultrasound-mediated-drug-delivery","score":0.7184,"url":"https://openalex.org/keywords/ultrasound-mediated-drug-delivery"},{"display_name":"tumor ablation","id":"tumor-ablation","score":0.2141,"url":"https://openalex.org/keywords/tumor-ablation"},{"display_name":"MR-guided focused ultrasound","id":"mri-guided-focused-ultrasound","score":0.4931,"url":"https://openalex.org/keywords/mri-guided-focused-ultrasound"},{"display_name":"microwave hyperthermia","id":"microwave-hyperthermia","score":0.498,"url":"https://openalex.org/keywords/microwave-hyperthermia"},{"display_name":"sonoporation","id":"sonoporation","score":0.7022,"url":"https://openalex.org/keywords/sonoporation"},{"display_name":"blood-brain barrier opening","id":"blood-brain-barrier-opening","score":0.6052,"url":"https://openalex.org/keywords/blood-brain-barrier-opening"},{"display_name":"tissue heating","id":"tissue-heating","score":0.2846,"url":"https://openalex.org/keywords/tissue-heating"},{"display_name":"tumor heating","id":"tumor-heating","score":0.6355,"url":"https://openalex.org/keywords/tumor-heating"},{"display_name":"inertial cavitation","id":"inertial-cavitation","score":0.7855,"url":"https://openalex.org/keywords/inertial-cavitation"},{"display_name":"MR thermometry","id":"mr-thermometry","score":0.4519,"url":"https://openalex.org/keywords/mr-thermometry"},{"display_name":"transcranial focused ultrasound","id":"transcranial-focused-ultrasound","score":0.7958,"url":"https://openalex.org/keywords/transcranial-focused-ultrasound"},{"display_name":"histotripsy","id":"histotripsy","score":0.7782,"url":"https://openalex.org/keywords/histotripsy"},{"display_name":"ultrasound-mediated gene delivery","id":"ultrasound-mediated-gene-delivery","score":0.7667,"url":"https://openalex.org/keywords/ultrasound-mediated-gene-delivery"},{"display_name":"thermal dose","id":"thermal-dose","score":0.5961,"url":"https://openalex.org/keywords/thermal-dose"},{"display_name":"transcranial ultrasound","id":"transcranial-ultrasound","score":0.2624,"url":"https://openalex.org/keywords/transcranial-ultrasound"},{"display_name":"local hyperthermia","id":"local-hyperthermia","score":0.4411,"url":"https://openalex.org/keywords/local-hyperthermia"},{"display_name":"ultrasound-triggered drug release","id":"ultrasound-triggered-drug-release","score":0.486,"url":"https://openalex.org/keywords/ultrasound-triggered-drug-release"},{"display_name":"ultrasound heating","id":"ultrasonic-heating","score":0.5687,"url":"https://openalex.org/keywords/ultrasonic-heating"},{"display_name":"mechanical index","id":"mechanical-index","score":0.6185,"url":"https://openalex.org/keywords/mechanical-index"}],"legacy_keywords":["Focused Ultrasound","Blood-Brain Barrier","Hyperthermia","Microbubbles","Drug Delivery","Cancer Treatment","MRI-Guided","Thermal Therapy","Ultrasound Contrast Agents","Noninvasive Treatment"],"openalex_id":"https://openalex.org/T10958","source_created_date":"2024-01-23T15:27:08","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2204","url":"/topics/T10958","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10958","works_count":64003,"label":"Ultrasound and Hyperthermia Applications","provider":"openalex","revision":"ba110ecbef0fb46f","taxonomy_revision":"f050b5d4780b1289","title":"Ultrasound and Hyperthermia Applications","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240456363200177","address_version":"morton4x16-v1","coordinates":[3,22,2204,10958],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}