{"cited_by_count":1690521,"description":"This cluster of papers explores the mechanisms and implications of cellular senescence, with a focus on telomere dynamics, tumor suppression, inflammation, DNA damage response, and the potential therapeutic role of senolytics in aging-related diseases.","display_name":"Telomeres, Telomerase, and Senescence","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10937","wikipedia":"https://en.wikipedia.org/wiki/Cellular_senescence"},"field_id":"27","id":"T10937","keywords":[{"display_name":"cellular senescence","id":"cellular-senescence","score":0.2734,"url":"https://openalex.org/keywords/cellular-senescence"},{"display_name":"telomere length","id":"telomere-length","score":0.5044,"url":"https://openalex.org/keywords/telomere-length"},{"display_name":"telomerase","id":"telomerase","score":0.6273,"url":"https://openalex.org/keywords/telomerase"},{"display_name":"telomere shortening","id":"telomere-shortening","score":0.6004,"url":"https://openalex.org/keywords/telomere-shortening"},{"display_name":"telomeres","id":"telomeres","score":0.4867,"url":"https://openalex.org/keywords/telomeres"},{"display_name":"telomerase activity","id":"telomerase-activity","score":0.5452,"url":"https://openalex.org/keywords/telomerase-activity"},{"display_name":"senescence-associated secretory phenotype","id":"senescence-associated-secretory-phenotype","score":0.4508,"url":"https://openalex.org/keywords/senescence-associated-secretory-phenotype"},{"display_name":"telomere maintenance","id":"telomere-maintenance","score":0.64,"url":"https://openalex.org/keywords/telomere-maintenance"},{"display_name":"telomerase reverse transcriptase","id":"tert","score":0.3926,"url":"https://openalex.org/keywords/tert"},{"display_name":"replicative senescence","id":"replicative-senescence","score":0.5633,"url":"https://openalex.org/keywords/replicative-senescence"},{"display_name":"senolytics","id":"senolytics","score":0.5299,"url":"https://openalex.org/keywords/senolytics"},{"display_name":"hTERT","id":"htert","score":0.4433,"url":"https://openalex.org/keywords/htert"},{"display_name":"cellular aging","id":"cellular-aging","score":0.253,"url":"https://openalex.org/keywords/cellular-aging"},{"display_name":"telomere dysfunction","id":"telomere-dysfunction","score":0.65,"url":"https://openalex.org/keywords/telomere-dysfunction"},{"display_name":"cell immortalization","id":"cell-immortalization","score":0.2924,"url":"https://openalex.org/keywords/cell-immortalization"},{"display_name":"alternative lengthening of telomeres","id":"alternative-lengthening-of-telomeres","score":0.7272,"url":"https://openalex.org/keywords/alternative-lengthening-of-telomeres"},{"display_name":"senescence-associated \u03b2-galactosidase","id":"senescence-associated-beta-galactosidase","score":0.4183,"url":"https://openalex.org/keywords/senescence-associated-beta-galactosidase"},{"display_name":"telomerase inhibition","id":"telomerase-inhibition","score":0.5276,"url":"https://openalex.org/keywords/telomerase-inhibition"},{"display_name":"leukocyte telomere length","id":"leukocyte-telomere-length","score":0.4749,"url":"https://openalex.org/keywords/leukocyte-telomere-length"},{"display_name":"telomere elongation","id":"telomere-elongation","score":0.7607,"url":"https://openalex.org/keywords/telomere-elongation"},{"display_name":"TRF2","id":"trf2","score":0.6494,"url":"https://openalex.org/keywords/trf2"},{"display_name":"telomerase RNA","id":"telomerase-rna","score":0.7335,"url":"https://openalex.org/keywords/telomerase-rna"},{"display_name":"telomerase inhibitors","id":"telomerase-inhibitors","score":0.5603,"url":"https://openalex.org/keywords/telomerase-inhibitors"},{"display_name":"telomere protection","id":"telomere-protection","score":0.7642,"url":"https://openalex.org/keywords/telomere-protection"},{"display_name":"oncogene-induced senescence","id":"oncogene-induced-senescence","score":0.5554,"url":"https://openalex.org/keywords/oncogene-induced-senescence"}],"legacy_keywords":["Senescence","Telomere","Tumor Suppression","Inflammation","Oncogene-induced Senescence","DNA Damage Response","Senolytics","Stem Cells","Aging","Telomerase"],"openalex_id":"https://openalex.org/T10937","source_created_date":"2024-01-23T15:27:08","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2737","url":"/topics/T10937","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10937","works_count":54060,"label":"Telomeres, Telomerase, and Senescence","provider":"openalex","revision":"47a4acb52805f8d9","taxonomy_revision":"f050b5d4780b1289","title":"Telomeres, Telomerase, and Senescence","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240731119984942","address_version":"morton4x16-v1","coordinates":[4,27,2737,10937],"answer_status":"Directory metadata; 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