{"cited_by_count":1475065,"description":"This cluster of papers explores the role of copper and zinc in health and disease, focusing on oxidative stress, antioxidant properties, metallothionein, neurological disorders, homeostasis, toxicity, immune function, and nutrition. The papers cover a wide range of topics including the molecular mechanisms, physiological roles, and clinical implications of copper and zinc in the human body.","display_name":"Trace Elements in Health","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10915","wikipedia":"https://en.wikipedia.org/wiki/Copper_toxicity#Human_health_effects"},"field_id":"29","id":"T10915","keywords":[{"display_name":"zinc deficiency","id":"zinc-deficiency","score":0.4265,"url":"https://openalex.org/keywords/zinc-deficiency"},{"display_name":"Wilson's disease","id":"wilson-s-disease","score":0.5343,"url":"https://openalex.org/keywords/wilson-s-disease"},{"display_name":"zinc supplementation","id":"zinc-supplementation","score":0.3773,"url":"https://openalex.org/keywords/zinc-supplementation"},{"display_name":"metallothionein","id":"metallothionein","score":0.3024,"url":"https://openalex.org/keywords/metallothionein"},{"display_name":"copper metabolism","id":"copper-metabolism","score":0.6724,"url":"https://openalex.org/keywords/copper-metabolism"},{"display_name":"serum zinc","id":"serum-zinc","score":0.5677,"url":"https://openalex.org/keywords/serum-zinc"},{"display_name":"copper deficiency","id":"copper-deficiency","score":0.4966,"url":"https://openalex.org/keywords/copper-deficiency"},{"display_name":"serum copper","id":"serum-copper","score":0.5926,"url":"https://openalex.org/keywords/serum-copper"},{"display_name":"ceruloplasmin","id":"ceruloplasmin","score":0.2654,"url":"https://openalex.org/keywords/ceruloplasmin"},{"display_name":"trace element deficiency","id":"trace-element-deficiency","score":0.5083,"url":"https://openalex.org/keywords/trace-element-deficiency"},{"display_name":"copper metabolism disorder","id":"copper-metabolism-disorder","score":0.6489,"url":"https://openalex.org/keywords/copper-metabolism-disorder"},{"display_name":"zinc metabolism","id":"zinc-metabolism","score":0.7608,"url":"https://openalex.org/keywords/zinc-metabolism"},{"display_name":"zinc homeostasis","id":"zinc-homeostasis","score":0.4972,"url":"https://openalex.org/keywords/zinc-homeostasis"},{"display_name":"copper accumulation","id":"copper-accumulation","score":0.3522,"url":"https://openalex.org/keywords/copper-accumulation"},{"display_name":"ATP7B","id":"atp7b","score":0.6522,"url":"https://openalex.org/keywords/atp7b"},{"display_name":"plasma zinc","id":"plasma-zinc-concentration","score":0.6541,"url":"https://openalex.org/keywords/plasma-zinc-concentration"},{"display_name":"copper homeostasis","id":"copper-homeostasis","score":0.4393,"url":"https://openalex.org/keywords/copper-homeostasis"},{"display_name":"zinc intake","id":"zinc-intake","score":0.3919,"url":"https://openalex.org/keywords/zinc-intake"},{"display_name":"Menkes disease","id":"menkes-disease","score":0.679,"url":"https://openalex.org/keywords/menkes-disease"},{"display_name":"zinc transporters","id":"zinc-transporters","score":0.5071,"url":"https://openalex.org/keywords/zinc-transporters"},{"display_name":"zinc status","id":"zinc-status","score":0.6611,"url":"https://openalex.org/keywords/zinc-status"},{"display_name":"dietary zinc","id":"dietary-zinc","score":0.4915,"url":"https://openalex.org/keywords/dietary-zinc"},{"display_name":"copper transport","id":"copper-transport","score":0.4778,"url":"https://openalex.org/keywords/copper-transport"},{"display_name":"metal homeostasis","id":"metal-homeostasis","score":0.2201,"url":"https://openalex.org/keywords/metal-homeostasis"},{"display_name":"zinc absorption","id":"zinc-absorption","score":0.571,"url":"https://openalex.org/keywords/zinc-absorption"}],"legacy_keywords":["Copper","Zinc","Oxidative Stress","Antioxidant","Metallothionein","Neurological Disorders","Homeostasis","Toxicity","Immune Function","Nutrition"],"openalex_id":"https://openalex.org/T10915","source_created_date":"2024-01-23T15:27:08","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2916","url":"/topics/T10915","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10915","works_count":84157,"label":"Trace Elements in Health","provider":"openalex","revision":"5718c20b47d9f0f3","taxonomy_revision":"f050b5d4780b1289","title":"Trace Elements in Health","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240747292403594","address_version":"morton4x16-v1","coordinates":[4,29,2916,10915],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}