{"cited_by_count":661516,"description":"This cluster of papers focuses on recent advances in multicomponent reactions, particularly in the context of green chemistry, heterocyclic synthesis, catalysis, and organic synthesis. It explores the use of nanocatalysts, isocyanides, and asymmetric synthesis in the development of sustainable methodologies for drug discovery.","display_name":"Multicomponent Synthesis of Heterocycles","domain_id":"3","external_ids":{"openalex":"https://openalex.org/T10817","wikipedia":"https://en.wikipedia.org/wiki/Multicomponent_reaction"},"field_id":"16","id":"T10817","keywords":[{"display_name":"multicomponent reactions","id":"multicomponent-reactions","score":0.4658,"url":"https://openalex.org/keywords/multicomponent-reactions"},{"display_name":"three-component reaction","id":"three-component-reaction","score":0.5052,"url":"https://openalex.org/keywords/three-component-reaction"},{"display_name":"solvent-free synthesis","id":"solvent-free-synthesis","score":0.2121,"url":"https://openalex.org/keywords/solvent-free-synthesis"},{"display_name":"aromatic aldehydes","id":"aromatic-aldehydes","score":0.276,"url":"https://openalex.org/keywords/aromatic-aldehydes"},{"display_name":"malononitrile","id":"malononitrile","score":0.4331,"url":"https://openalex.org/keywords/malononitrile"},{"display_name":"Biginelli reaction","id":"biginelli-reaction","score":0.7695,"url":"https://openalex.org/keywords/biginelli-reaction"},{"display_name":"one-pot three-component reaction","id":"one-pot-three-component-reaction","score":0.6809,"url":"https://openalex.org/keywords/one-pot-three-component-reaction"},{"display_name":"recyclable catalyst","id":"reusable-catalyst","score":0.2438,"url":"https://openalex.org/keywords/reusable-catalyst"},{"display_name":"Ugi reaction","id":"ugi-reaction","score":0.6158,"url":"https://openalex.org/keywords/ugi-reaction"},{"display_name":"isocyanides","id":"isocyanides","score":0.264,"url":"https://openalex.org/keywords/isocyanides"},{"display_name":"dimedone","id":"dimedone","score":0.5573,"url":"https://openalex.org/keywords/dimedone"},{"display_name":"catalyst-free synthesis","id":"catalyst-free-synthesis","score":0.2311,"url":"https://openalex.org/keywords/catalyst-free-synthesis"},{"display_name":"one-pot multicomponent reaction","id":"one-pot-multicomponent-reaction","score":0.693,"url":"https://openalex.org/keywords/one-pot-multicomponent-reaction"},{"display_name":"ammonium acetate","id":"ammonium-acetate","score":0.2984,"url":"https://openalex.org/keywords/ammonium-acetate"},{"display_name":"multicomponent synthesis","id":"multicomponent-synthesis","score":0.5251,"url":"https://openalex.org/keywords/multicomponent-synthesis"},{"display_name":"ethyl acetoacetate","id":"ethyl-acetoacetate","score":0.2727,"url":"https://openalex.org/keywords/ethyl-acetoacetate"},{"display_name":"four-component reaction","id":"four-component-reaction","score":0.661,"url":"https://openalex.org/keywords/four-component-reaction"},{"display_name":"isatin","id":"isatin","score":0.2143,"url":"https://openalex.org/keywords/isatin"},{"display_name":"3,4-dihydropyrimidin-2(1H)-ones","id":"3-4-dihydropyrimidin-2-1h-ones","score":0.8425,"url":"https://openalex.org/keywords/3-4-dihydropyrimidin-2-1h-ones"},{"display_name":"magnetic nanocatalyst","id":"magnetic-nanocatalyst","score":0.3943,"url":"https://openalex.org/keywords/magnetic-nanocatalyst"},{"display_name":"4-hydroxycoumarin","id":"4-hydroxycoumarin","score":0.2878,"url":"https://openalex.org/keywords/4-hydroxycoumarin"},{"display_name":"dihydropyrimidinones","id":"dihydropyrimidinones","score":0.5752,"url":"https://openalex.org/keywords/dihydropyrimidinones"},{"display_name":"spirooxindoles","id":"spirooxindoles","score":0.2008,"url":"https://openalex.org/keywords/spirooxindoles"},{"display_name":"ethyl cyanoacetate","id":"ethyl-cyanoacetate","score":0.2298,"url":"https://openalex.org/keywords/ethyl-cyanoacetate"},{"display_name":"Passerini reaction","id":"passerini-reaction","score":0.524,"url":"https://openalex.org/keywords/passerini-reaction"}],"legacy_keywords":["Multicomponent Reactions","Green Chemistry","Heterocyclic Synthesis","Catalysis","Organic Synthesis","Nanocatalysts","Isocyanides","Asymmetric Synthesis","Drug Discovery","Sustainable Methodologies"],"openalex_id":"https://openalex.org/T10817","source_created_date":"2024-01-23T15:27:08","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1605","url":"/topics/T10817","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10817","works_count":44049,"label":"Multicomponent Synthesis of Heterocycles","provider":"openalex","revision":"7979c835bd11a3f6","taxonomy_revision":"f050b5d4780b1289","title":"Multicomponent Synthesis of Heterocycles","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36174757389009949","address_version":"morton4x16-v1","coordinates":[3,16,1605,10817],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}