{"cited_by_count":2823710,"description":"This cluster of papers explores the mechanisms of estrogen receptor signaling, with a focus on its role in breast cancer, interactions with glucocorticoids, and the effects of various drugs such as tamoxifen and aromatase inhibitors. It delves into the molecular pathways, gene regulation, and coactivator/coregulator dynamics involved in estrogen signaling.","display_name":"Estrogen and related hormone effects","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10756","wikipedia":"https://en.wikipedia.org/wiki/Estrogen_receptor"},"field_id":"13","id":"T10756","keywords":[{"display_name":"estrogen receptor","id":"estrogen-receptor","score":0.2509,"url":"https://openalex.org/keywords/estrogen-receptor"},{"display_name":"estrogen receptor alpha","id":"estrogen-receptor-alpha","score":0.3744,"url":"https://openalex.org/keywords/estrogen-receptor-alpha"},{"display_name":"glucocorticoid receptor","id":"glucocorticoid-receptor","score":0.2082,"url":"https://openalex.org/keywords/glucocorticoid-receptor"},{"display_name":"estrogen receptor beta","id":"estrogen-receptor-beta","score":0.3826,"url":"https://openalex.org/keywords/estrogen-receptor-beta"},{"display_name":"antiestrogens","id":"antiestrogens","score":0.4902,"url":"https://openalex.org/keywords/antiestrogens"},{"display_name":"selective estrogen receptor modulators","id":"selective-estrogen-receptor-modulators","score":0.2963,"url":"https://openalex.org/keywords/selective-estrogen-receptor-modulators"},{"display_name":"steroid hormone receptors","id":"steroid-hormone-receptors","score":0.4069,"url":"https://openalex.org/keywords/steroid-hormone-receptors"},{"display_name":"estrogen signaling","id":"estrogen-signaling","score":0.4419,"url":"https://openalex.org/keywords/estrogen-signaling"},{"display_name":"estrone","id":"estrone","score":0.2357,"url":"https://openalex.org/keywords/estrone"},{"display_name":"aromatase","id":"aromatase","score":0.2452,"url":"https://openalex.org/keywords/aromatase"},{"display_name":"tamoxifen resistance","id":"tamoxifen-resistance","score":0.4858,"url":"https://openalex.org/keywords/tamoxifen-resistance"},{"display_name":"fulvestrant","id":"fulvestrant","score":0.2372,"url":"https://openalex.org/keywords/fulvestrant"},{"display_name":"endocrine therapy resistance","id":"endocrine-resistance","score":0.2552,"url":"https://openalex.org/keywords/endocrine-resistance"},{"display_name":"estrogen metabolism","id":"estrogen-metabolism","score":0.3589,"url":"https://openalex.org/keywords/estrogen-metabolism"},{"display_name":"estrogen response element","id":"estrogen-response-element","score":0.6484,"url":"https://openalex.org/keywords/estrogen-response-element"},{"display_name":"estrogen synthesis","id":"estrogen-biosynthesis","score":0.4004,"url":"https://openalex.org/keywords/estrogen-biosynthesis"},{"display_name":"oestrogen receptor","id":"oestrogen-receptor","score":0.2944,"url":"https://openalex.org/keywords/oestrogen-receptor"},{"display_name":"estriol","id":"estriol","score":0.246,"url":"https://openalex.org/keywords/estriol"},{"display_name":"raloxifene","id":"raloxifene","score":0.2065,"url":"https://openalex.org/keywords/raloxifene"},{"display_name":"G protein-coupled estrogen receptor","id":"g-protein-coupled-estrogen-receptor","score":0.4118,"url":"https://openalex.org/keywords/g-protein-coupled-estrogen-receptor"},{"display_name":"4-hydroxytamoxifen","id":"4-hydroxytamoxifen","score":0.4176,"url":"https://openalex.org/keywords/4-hydroxytamoxifen"},{"display_name":"hormone-dependent tumors","id":"hormone-dependent-cancers","score":0.2927,"url":"https://openalex.org/keywords/hormone-dependent-cancers"},{"display_name":"non-genomic estrogen signaling","id":"nongenomic-estrogen-signaling","score":0.6332,"url":"https://openalex.org/keywords/nongenomic-estrogen-signaling"},{"display_name":"estradiol binding","id":"estradiol-binding","score":0.7523,"url":"https://openalex.org/keywords/estradiol-binding"},{"display_name":"steroid hormone signaling","id":"steroid-hormone-signaling","score":0.3597,"url":"https://openalex.org/keywords/steroid-hormone-signaling"}],"legacy_keywords":["Estrogen","Receptor","Signaling","Breast Cancer","Glucocorticoids","Nuclear Receptors","Tamoxifen","Aromatase Inhibitors","G Protein-Coupled Receptor","Transcriptional Regulation"],"openalex_id":"https://openalex.org/T10756","source_created_date":"2024-01-23T15:27:08","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1311","url":"/topics/T10756","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10756","works_count":121646,"label":"Estrogen and related hormone effects","provider":"openalex","revision":"19ba7eab0bcb5428","taxonomy_revision":"f050b5d4780b1289","title":"Estrogen and related hormone effects","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36174499489803847","address_version":"morton4x16-v1","coordinates":[1,13,1311,10756],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}