{"cited_by_count":2181374,"description":"This cluster of papers explores the role of insulin-like growth factors (IGFs) in various aspects of health and disease, including their involvement in cancer development and progression, regulation of metabolism, impact on bone growth, neuroendocrine control, and association with conditions like hypopituitarism. It also discusses the signaling pathways and potential therapeutic implications related to IGFs.","display_name":"Growth Hormone and Insulin-like Growth Factors","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10748","wikipedia":"https://en.wikipedia.org/wiki/Insulin-like_growth_factor"},"field_id":"27","id":"T10748","keywords":[{"display_name":"insulin-like growth factor I","id":"insulin-like-growth-factor-i","score":0.3147,"url":"https://openalex.org/keywords/insulin-like-growth-factor-i"},{"display_name":"growth hormone","id":"growth-hormone","score":0.4041,"url":"https://openalex.org/keywords/growth-hormone"},{"display_name":"growth hormone deficiency","id":"growth-hormone-deficiency","score":0.6608,"url":"https://openalex.org/keywords/growth-hormone-deficiency"},{"display_name":"growth hormone therapy","id":"growth-hormone-therapy","score":0.6762,"url":"https://openalex.org/keywords/growth-hormone-therapy"},{"display_name":"short stature","id":"short-stature","score":0.2843,"url":"https://openalex.org/keywords/short-stature"},{"display_name":"growth hormone secretion","id":"growth-hormone-secretion","score":0.6457,"url":"https://openalex.org/keywords/growth-hormone-secretion"},{"display_name":"insulin-like growth factor II","id":"igf-ii","score":0.3674,"url":"https://openalex.org/keywords/igf-ii"},{"display_name":"IGF-1 receptor","id":"igf-1-receptor","score":0.3041,"url":"https://openalex.org/keywords/igf-1-receptor"},{"display_name":"recombinant human growth hormone","id":"recombinant-human-growth-hormone","score":0.6041,"url":"https://openalex.org/keywords/recombinant-human-growth-hormone"},{"display_name":"IGF binding proteins","id":"insulin-like-growth-factor-binding-proteins","score":0.6629,"url":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins"},{"display_name":"insulin-like growth factor","id":"insulin-like-growth-factor","score":0.4184,"url":"https://openalex.org/keywords/insulin-like-growth-factor"},{"display_name":"growth hormone-releasing hormone","id":"growth-hormone-releasing-hormone","score":0.6163,"url":"https://openalex.org/keywords/growth-hormone-releasing-hormone"},{"display_name":"growth hormone receptor","id":"growth-hormone-receptor","score":0.6059,"url":"https://openalex.org/keywords/growth-hormone-receptor"},{"display_name":"IGFBP-3","id":"igfbp-3","score":0.4924,"url":"https://openalex.org/keywords/igfbp-3"},{"display_name":"human growth hormone","id":"human-growth-hormone","score":0.4832,"url":"https://openalex.org/keywords/human-growth-hormone"},{"display_name":"growth hormone replacement therapy","id":"growth-hormone-replacement-therapy","score":0.8107,"url":"https://openalex.org/keywords/growth-hormone-replacement-therapy"},{"display_name":"growth disorders","id":"growth-disorders","score":0.3345,"url":"https://openalex.org/keywords/growth-disorders"},{"display_name":"prolactin secretion","id":"prolactin-secretion","score":0.2427,"url":"https://openalex.org/keywords/prolactin-secretion"},{"display_name":"adult height","id":"adult-height","score":0.2916,"url":"https://openalex.org/keywords/adult-height"},{"display_name":"prolactin receptor","id":"prolactin-receptor","score":0.3748,"url":"https://openalex.org/keywords/prolactin-receptor"},{"display_name":"IGF binding protein-3","id":"igf-binding-protein-3","score":0.6537,"url":"https://openalex.org/keywords/igf-binding-protein-3"},{"display_name":"idiopathic short stature","id":"idiopathic-short-stature","score":0.7806,"url":"https://openalex.org/keywords/idiopathic-short-stature"},{"display_name":"somatotropic axis","id":"gh-igf-1-axis","score":0.5872,"url":"https://openalex.org/keywords/gh-igf-1-axis"},{"display_name":"insulin-like growth factor binding protein-3","id":"insulin-like-growth-factor-binding-protein-3","score":0.5155,"url":"https://openalex.org/keywords/insulin-like-growth-factor-binding-protein-3"},{"display_name":"IGFBP-1","id":"igfbp-1","score":0.3821,"url":"https://openalex.org/keywords/igfbp-1"}],"legacy_keywords":["Insulin-like Growth Factors","IGF-1","Growth Hormone","Cancer","Metabolism","Hypopituitarism","Receptor Signaling","Bone Growth","Neuroendocrine Control","Prolactin"],"openalex_id":"https://openalex.org/T10748","source_created_date":"2024-01-23T15:27:07","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2712","url":"/topics/T10748","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10748","works_count":108375,"label":"Growth Hormone and Insulin-like Growth Factors","provider":"openalex","revision":"de9a6aea2ea8d41c","taxonomy_revision":"f050b5d4780b1289","title":"Growth Hormone and Insulin-like Growth Factors","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240215853951266","address_version":"morton4x16-v1","coordinates":[4,27,2712,10748],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}