{"cited_by_count":2196321,"description":"This cluster of papers explores the molecular mechanisms, physiological roles, and pathophysiological implications of aquaporins, a family of water channel proteins involved in ion transport across cell membranes. The research covers various aspects such as brain edema, kidney function, regulation, and the role of aquaporins in disease.","display_name":"Ion Transport and Channel Regulation","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10724","wikipedia":"https://en.wikipedia.org/wiki/Aquaporin"},"field_id":"13","id":"T10724","keywords":[{"display_name":"Na+/K+-ATPase","id":"na-k-atpase","score":0.2803,"url":"https://openalex.org/keywords/na-k-atpase"},{"display_name":"aquaporins","id":"aquaporins","score":0.424,"url":"https://openalex.org/keywords/aquaporins"},{"display_name":"sodium transport","id":"sodium-transport","score":0.4212,"url":"https://openalex.org/keywords/sodium-transport"},{"display_name":"ouabain","id":"ouabain","score":0.271,"url":"https://openalex.org/keywords/ouabain"},{"display_name":"proximal tubule","id":"proximal-tubule","score":0.2047,"url":"https://openalex.org/keywords/proximal-tubule"},{"display_name":"aquaporin-2","id":"aquaporin-2","score":0.6436,"url":"https://openalex.org/keywords/aquaporin-2"},{"display_name":"amiloride","id":"amiloride","score":0.303,"url":"https://openalex.org/keywords/amiloride"},{"display_name":"aquaporin-1","id":"aquaporin-1","score":0.4924,"url":"https://openalex.org/keywords/aquaporin-1"},{"display_name":"aquaporin-4","id":"aquaporin-4","score":0.3306,"url":"https://openalex.org/keywords/aquaporin-4"},{"display_name":"epithelial sodium channel","id":"enac","score":0.3471,"url":"https://openalex.org/keywords/enac"},{"display_name":"Na+/H+ exchanger","id":"na-h-exchanger","score":0.3948,"url":"https://openalex.org/keywords/na-h-exchanger"},{"display_name":"cell volume regulation","id":"cell-volume-regulation","score":0.4708,"url":"https://openalex.org/keywords/cell-volume-regulation"},{"display_name":"sodium reabsorption","id":"sodium-reabsorption","score":0.3966,"url":"https://openalex.org/keywords/sodium-reabsorption"},{"display_name":"chloride transport","id":"chloride-transport","score":0.3076,"url":"https://openalex.org/keywords/chloride-transport"},{"display_name":"collecting duct","id":"collecting-duct","score":0.3714,"url":"https://openalex.org/keywords/collecting-duct"},{"display_name":"basolateral membrane","id":"basolateral-membrane","score":0.3559,"url":"https://openalex.org/keywords/basolateral-membrane"},{"display_name":"Na+/H+ exchange","id":"na-h-exchange","score":0.4343,"url":"https://openalex.org/keywords/na-h-exchange"},{"display_name":"sodium uptake","id":"sodium-absorption","score":0.2581,"url":"https://openalex.org/keywords/sodium-absorption"},{"display_name":"potassium transport","id":"potassium-transport","score":0.2424,"url":"https://openalex.org/keywords/potassium-transport"},{"display_name":"AQP3","id":"aquaporin-3","score":0.4668,"url":"https://openalex.org/keywords/aquaporin-3"},{"display_name":"NHE3","id":"nhe3","score":0.4955,"url":"https://openalex.org/keywords/nhe3"},{"display_name":"cell swelling","id":"cell-swelling","score":0.2605,"url":"https://openalex.org/keywords/cell-swelling"},{"display_name":"water reabsorption","id":"water-reabsorption","score":0.4959,"url":"https://openalex.org/keywords/water-reabsorption"},{"display_name":"chloride secretion","id":"chloride-secretion","score":0.2873,"url":"https://openalex.org/keywords/chloride-secretion"},{"display_name":"epithelial ion transport","id":"epithelial-ion-transport","score":0.504,"url":"https://openalex.org/keywords/epithelial-ion-transport"}],"legacy_keywords":["Aquaporins","Water Channels","Ion Transport","Cell Membrane","Physiology","Pathophysiology","Brain Edema","Kidney Function","Regulation","Disease"],"openalex_id":"https://openalex.org/T10724","source_created_date":"2024-01-23T15:27:07","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T10724","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10724","works_count":96199,"label":"Ion Transport and Channel Regulation","provider":"openalex","revision":"19aa60b8a9852e32","taxonomy_revision":"f050b5d4780b1289","title":"Ion Transport and Channel Regulation","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36173986387732995","address_version":"morton4x16-v1","coordinates":[1,13,1312,10724],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}