{"cited_by_count":1498860,"description":"This cluster of papers focuses on the incidence, risk factors, and management of viral-related cancers, particularly associated with Epstein-Barr virus (EBV) and Kaposi's Sarcoma-associated herpesvirus (KSHV), in immunocompromised individuals such as HIV/AIDS patients and transplant recipients. It explores the impact of immunosuppression, antiretroviral therapy, and viral reactivation on cancer development, as well as the use of targeted therapies and immune-based treatments for these malignancies.","display_name":"Viral-associated cancers and disorders","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10685","wikipedia":"https://en.wikipedia.org/wiki/Epstein%E2%80%93Barr_virus-associated_lymphoproliferative_disease"},"field_id":"27","id":"T10685","keywords":[{"display_name":"Epstein-Barr virus","id":"epstein-barr-virus","score":0.5085,"url":"https://openalex.org/keywords/epstein-barr-virus"},{"display_name":"Kaposi's sarcoma","id":"kaposi-sarcoma","score":0.6253,"url":"https://openalex.org/keywords/kaposi-sarcoma"},{"display_name":"infectious mononucleosis","id":"infectious-mononucleosis","score":0.614,"url":"https://openalex.org/keywords/infectious-mononucleosis"},{"display_name":"human herpesvirus 8","id":"human-herpesvirus-8","score":0.7899,"url":"https://openalex.org/keywords/human-herpesvirus-8"},{"display_name":"Kaposi's sarcoma-associated herpesvirus","id":"kaposi-s-sarcoma-associated-herpesvirus","score":0.761,"url":"https://openalex.org/keywords/kaposi-s-sarcoma-associated-herpesvirus"},{"display_name":"viral oncogenesis","id":"viral-carcinogenesis","score":0.3124,"url":"https://openalex.org/keywords/viral-carcinogenesis"},{"display_name":"post-transplant lymphoproliferative disorder","id":"post-transplant-lymphoproliferative-disorder","score":0.5758,"url":"https://openalex.org/keywords/post-transplant-lymphoproliferative-disorder"},{"display_name":"Burkitt lymphoma","id":"burkitt-lymphoma","score":0.2294,"url":"https://openalex.org/keywords/burkitt-lymphoma"},{"display_name":"lymphoproliferative disorders","id":"lymphoproliferative-disorders","score":0.2004,"url":"https://openalex.org/keywords/lymphoproliferative-disorders"},{"display_name":"viral latency","id":"viral-latency","score":0.2165,"url":"https://openalex.org/keywords/viral-latency"},{"display_name":"oncogenic viruses","id":"oncogenic-viruses","score":0.4283,"url":"https://openalex.org/keywords/oncogenic-viruses"},{"display_name":"primary effusion lymphoma","id":"primary-effusion-lymphoma","score":0.8318,"url":"https://openalex.org/keywords/primary-effusion-lymphoma"},{"display_name":"AIDS-related Kaposi's sarcoma","id":"aids-associated-kaposi-s-sarcoma","score":0.9132,"url":"https://openalex.org/keywords/aids-associated-kaposi-s-sarcoma"},{"display_name":"HIV-associated lymphoma","id":"hiv-associated-lymphoma","score":0.6318,"url":"https://openalex.org/keywords/hiv-associated-lymphoma"},{"display_name":"Epstein-Barr virus infection","id":"epstein-barr-virus-infection","score":0.3576,"url":"https://openalex.org/keywords/epstein-barr-virus-infection"},{"display_name":"latent membrane protein 1","id":"latent-membrane-protein-1","score":0.6092,"url":"https://openalex.org/keywords/latent-membrane-protein-1"},{"display_name":"multicentric Castleman disease","id":"multicentric-castleman-disease","score":0.6552,"url":"https://openalex.org/keywords/multicentric-castleman-disease"},{"display_name":"HIV-associated malignancies","id":"hiv-associated-malignancies","score":0.5957,"url":"https://openalex.org/keywords/hiv-associated-malignancies"},{"display_name":"EBNA1","id":"ebna1","score":0.5879,"url":"https://openalex.org/keywords/ebna1"},{"display_name":"EBV-encoded RNA","id":"ebv-encoded-rna","score":0.6727,"url":"https://openalex.org/keywords/ebv-encoded-rna"},{"display_name":"gammaherpesvirus","id":"gammaherpesviruses","score":0.4846,"url":"https://openalex.org/keywords/gammaherpesviruses"},{"display_name":"EBNA2","id":"ebna2","score":0.7417,"url":"https://openalex.org/keywords/ebna2"},{"display_name":"LMP1","id":"lmp1","score":0.5468,"url":"https://openalex.org/keywords/lmp1"},{"display_name":"viral etiology of cancer","id":"viral-etiology-of-cancer","score":0.4619,"url":"https://openalex.org/keywords/viral-etiology-of-cancer"},{"display_name":"plasmablastic lymphoma","id":"plasmablastic-lymphoma","score":0.4723,"url":"https://openalex.org/keywords/plasmablastic-lymphoma"}],"legacy_keywords":["Epstein-Barr Virus","Kaposi's Sarcoma","HIV/AIDS","Transplant Recipients","Lymphoproliferative Disorders","Human Herpesvirus 8","Cancer Incidence","Immunosuppression","Post-Transplant Lymphoproliferative Disease","Viral Oncogenesis"],"openalex_id":"https://openalex.org/T10685","source_created_date":"2024-01-23T15:27:07","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T10685","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10685","works_count":81914,"label":"Viral-associated cancers and disorders","provider":"openalex","revision":"e43abcb50308aa9b","taxonomy_revision":"f050b5d4780b1289","title":"Viral-associated cancers and disorders","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240215723665770","address_version":"morton4x16-v1","coordinates":[4,27,2730,10685],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}