{"cited_by_count":2034953,"description":"This cluster of papers explores the metabolic reprogramming in cancer cells, focusing on the role of hypoxia-inducible factor 1 (HIF-1), the Warburg effect, tumor hypoxia, glutamine metabolism, and the impact of the tumor microenvironment on cancer cell metabolism. It also delves into oxygen sensing, mitochondrial metabolism, glycolysis inhibition, and the role of hexokinase II in cancer progression.","display_name":"Cancer, Hypoxia, and Metabolism","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10631","wikipedia":"https://en.wikipedia.org/wiki/Cancer_metabolism"},"field_id":"13","id":"T10631","keywords":[{"display_name":"cancer metabolism","id":"tumor-metabolism","score":0.3196,"url":"https://openalex.org/keywords/tumor-metabolism"},{"display_name":"tumor hypoxia","id":"tumor-hypoxia","score":0.2637,"url":"https://openalex.org/keywords/tumor-hypoxia"},{"display_name":"HIF-1\u03b1","id":"hif-1alpha","score":0.2028,"url":"https://openalex.org/keywords/hif-1alpha"},{"display_name":"Warburg effect","id":"warburg-effect","score":0.4737,"url":"https://openalex.org/keywords/warburg-effect"},{"display_name":"aerobic glycolysis","id":"aerobic-glycolysis","score":0.4155,"url":"https://openalex.org/keywords/aerobic-glycolysis"},{"display_name":"hypoxia-inducible factor","id":"hypoxia-inducible-factor","score":0.3116,"url":"https://openalex.org/keywords/hypoxia-inducible-factor"},{"display_name":"hypoxia-inducible factor-1\u03b1","id":"hypoxia-inducible-factor-1alpha","score":0.2066,"url":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha"},{"display_name":"HIF-1","id":"hypoxia-inducible-factor-1","score":0.3021,"url":"https://openalex.org/keywords/hypoxia-inducible-factor-1"},{"display_name":"HIF-2\u03b1","id":"hif-2alpha","score":0.2707,"url":"https://openalex.org/keywords/hif-2alpha"},{"display_name":"glutamine metabolism","id":"glutamine-metabolism","score":0.2315,"url":"https://openalex.org/keywords/glutamine-metabolism"},{"display_name":"PKM2","id":"pkm2","score":0.3039,"url":"https://openalex.org/keywords/pkm2"},{"display_name":"LDHA","id":"ldha","score":0.3176,"url":"https://openalex.org/keywords/ldha"},{"display_name":"tumor oxygenation","id":"tumor-oxygenation","score":0.3281,"url":"https://openalex.org/keywords/tumor-oxygenation"},{"display_name":"tumor metabolic reprogramming","id":"cancer-metabolic-reprogramming","score":0.3825,"url":"https://openalex.org/keywords/cancer-metabolic-reprogramming"},{"display_name":"glycolysis inhibition","id":"glycolysis-inhibition","score":0.2159,"url":"https://openalex.org/keywords/glycolysis-inhibition"},{"display_name":"hexokinase 2","id":"hexokinase-2","score":0.2663,"url":"https://openalex.org/keywords/hexokinase-2"},{"display_name":"MCT1","id":"mct1","score":0.221,"url":"https://openalex.org/keywords/mct1"},{"display_name":"glutaminolysis","id":"glutaminolysis","score":0.3233,"url":"https://openalex.org/keywords/glutaminolysis"},{"display_name":"glucose transporter 1","id":"glucose-transporter-1","score":0.2105,"url":"https://openalex.org/keywords/glucose-transporter-1"},{"display_name":"metabolic vulnerability","id":"metabolic-vulnerability","score":0.2905,"url":"https://openalex.org/keywords/metabolic-vulnerability"},{"display_name":"MCT4","id":"mct4","score":0.3302,"url":"https://openalex.org/keywords/mct4"},{"display_name":"hypoxia response element","id":"hypoxia-response-element","score":0.3369,"url":"https://openalex.org/keywords/hypoxia-response-element"},{"display_name":"prolyl hydroxylase","id":"prolyl-hydroxylase","score":0.2535,"url":"https://openalex.org/keywords/prolyl-hydroxylase"},{"display_name":"monocarboxylate transporters","id":"monocarboxylate-transporters","score":0.2285,"url":"https://openalex.org/keywords/monocarboxylate-transporters"},{"display_name":"HIF-1\u03b1 stabilization","id":"hif-1alpha-stabilization","score":0.3546,"url":"https://openalex.org/keywords/hif-1alpha-stabilization"}],"legacy_keywords":["HIF-1","Warburg Effect","Tumor Hypoxia","Cancer Cell Metabolism","Glutamine Metabolism","Oxygen Sensing","Mitochondrial Metabolism","Glycolysis Inhibition","Tumor Microenvironment","Hexokinase II"],"openalex_id":"https://openalex.org/T10631","source_created_date":"2024-01-23T15:27:07","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1306","url":"/topics/T10631","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10631","works_count":63177,"label":"Cancer, Hypoxia, and Metabolism","provider":"openalex","revision":"e0bd0cb2e8aae02e","taxonomy_revision":"f050b5d4780b1289","title":"Cancer, Hypoxia, and Metabolism","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36173986241211083","address_version":"morton4x16-v1","coordinates":[1,13,1306,10631],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}