{"cited_by_count":3519846,"description":"This cluster of papers explores the intricate mechanisms involved in intracellular membrane trafficking, including endocytosis, membrane fusion, the roles of Rab proteins and SNARE proteins, the function of ESCRT machinery, the impact of phosphoinositides, and the biogenesis of lysosomes. It covers a wide range of processes such as vesicle traffic, lysosome biogenesis, and the molecular machinery involved in clathrin-mediated endocytosis.","display_name":"Cellular transport and secretion","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10617","wikipedia":"https://en.wikipedia.org/wiki/Intracellular_membrane_trafficking"},"field_id":"13","id":"T10617","keywords":[{"display_name":"Golgi apparatus","id":"golgi-apparatus","score":0.283,"url":"https://openalex.org/keywords/golgi-apparatus"},{"display_name":"endocytosis","id":"endocytosis","score":0.2594,"url":"https://openalex.org/keywords/endocytosis"},{"display_name":"exocytosis","id":"exocytosis","score":0.4327,"url":"https://openalex.org/keywords/exocytosis"},{"display_name":"membrane trafficking","id":"membrane-trafficking","score":0.5635,"url":"https://openalex.org/keywords/membrane-trafficking"},{"display_name":"vesicle trafficking","id":"vesicular-trafficking","score":0.3979,"url":"https://openalex.org/keywords/vesicular-trafficking"},{"display_name":"membrane fusion","id":"membrane-fusion","score":0.34,"url":"https://openalex.org/keywords/membrane-fusion"},{"display_name":"SNARE proteins","id":"snare-proteins","score":0.6472,"url":"https://openalex.org/keywords/snare-proteins"},{"display_name":"clathrin-mediated endocytosis","id":"clathrin-mediated-endocytosis","score":0.3914,"url":"https://openalex.org/keywords/clathrin-mediated-endocytosis"},{"display_name":"secretory pathway","id":"secretory-pathway","score":0.4205,"url":"https://openalex.org/keywords/secretory-pathway"},{"display_name":"trans-Golgi network","id":"trans-golgi-network","score":0.5922,"url":"https://openalex.org/keywords/trans-golgi-network"},{"display_name":"Rab GTPases","id":"rab-gtpases","score":0.5593,"url":"https://openalex.org/keywords/rab-gtpases"},{"display_name":"endosomes","id":"endosomes","score":0.3661,"url":"https://openalex.org/keywords/endosomes"},{"display_name":"protein sorting","id":"protein-sorting","score":0.5511,"url":"https://openalex.org/keywords/protein-sorting"},{"display_name":"endosomal trafficking","id":"endosomal-trafficking","score":0.4238,"url":"https://openalex.org/keywords/endosomal-trafficking"},{"display_name":"vesicle fusion","id":"vesicle-fusion","score":0.424,"url":"https://openalex.org/keywords/vesicle-fusion"},{"display_name":"early endosomes","id":"early-endosomes","score":0.502,"url":"https://openalex.org/keywords/early-endosomes"},{"display_name":"small GTPases","id":"small-gtpases","score":0.2122,"url":"https://openalex.org/keywords/small-gtpases"},{"display_name":"synaptic vesicle exocytosis","id":"synaptic-vesicle-exocytosis","score":0.5438,"url":"https://openalex.org/keywords/synaptic-vesicle-exocytosis"},{"display_name":"SNARE complex","id":"snare-complex","score":0.7096,"url":"https://openalex.org/keywords/snare-complex"},{"display_name":"late endosomes","id":"late-endosomes","score":0.4088,"url":"https://openalex.org/keywords/late-endosomes"},{"display_name":"clathrin","id":"clathrin","score":0.5885,"url":"https://openalex.org/keywords/clathrin"},{"display_name":"endosomal sorting","id":"endosomal-sorting","score":0.7054,"url":"https://openalex.org/keywords/endosomal-sorting"},{"display_name":"multivesicular bodies","id":"multivesicular-bodies","score":0.3307,"url":"https://openalex.org/keywords/multivesicular-bodies"},{"display_name":"dynamin","id":"dynamin","score":0.4683,"url":"https://openalex.org/keywords/dynamin"},{"display_name":"SNAP-25","id":"snap-25","score":0.3883,"url":"https://openalex.org/keywords/snap-25"}],"legacy_keywords":["Endocytosis","Membrane Fusion","Rab Proteins","Clathrin-Mediated Endocytosis","SNARE Proteins","ESCRT Machinery","Phosphoinositides","Vesicle Traffic","Lysosome Biogenesis","Dynamin"],"openalex_id":"https://openalex.org/T10617","source_created_date":"2024-01-23T15:27:07","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T10617","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10617","works_count":97847,"label":"Cellular transport and secretion","provider":"openalex","revision":"661c18fded34310e","taxonomy_revision":"f050b5d4780b1289","title":"Cellular transport and secretion","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36173984236888655","address_version":"morton4x16-v1","coordinates":[1,13,1307,10617],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}