{"cited_by_count":2773233,"description":"This cluster of papers focuses on the p53 signaling network, exploring its role in cell cycle regulation, tumor suppression, cancer therapy, apoptosis, and the impact of mutations. The papers cover various aspects of p53-MDM2 interaction, cyclin-dependent kinases, and the intricate mechanisms of p53 regulation in the context of cancer research.","display_name":"Cancer-related Molecular Pathways","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10583","wikipedia":"https://en.wikipedia.org/wiki/P53"},"field_id":"27","id":"T10583","keywords":[{"display_name":"MDM2","id":"mdm2","score":0.4192,"url":"https://openalex.org/keywords/mdm2"},{"display_name":"retinoblastoma protein","id":"retinoblastoma-protein","score":0.2741,"url":"https://openalex.org/keywords/retinoblastoma-protein"},{"display_name":"cyclin-dependent kinases","id":"cyclin-dependent-kinases","score":0.2617,"url":"https://openalex.org/keywords/cyclin-dependent-kinases"},{"display_name":"cyclin-dependent kinase inhibitors","id":"cyclin-dependent-kinase-inhibitors","score":0.2499,"url":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors"},{"display_name":"mutant p53","id":"mutant-p53","score":0.5128,"url":"https://openalex.org/keywords/mutant-p53"},{"display_name":"CDK2","id":"cdk2","score":0.2069,"url":"https://openalex.org/keywords/cdk2"},{"display_name":"tumor suppressor proteins","id":"tumor-suppressor-proteins","score":0.2783,"url":"https://openalex.org/keywords/tumor-suppressor-proteins"},{"display_name":"E2F1","id":"e2f1","score":0.2182,"url":"https://openalex.org/keywords/e2f1"},{"display_name":"p73","id":"p73","score":0.4088,"url":"https://openalex.org/keywords/p73"},{"display_name":"G1/S transition","id":"g1-s-transition","score":0.205,"url":"https://openalex.org/keywords/g1-s-transition"},{"display_name":"cyclin E","id":"cyclin-e","score":0.2215,"url":"https://openalex.org/keywords/cyclin-e"},{"display_name":"p53 stabilization","id":"p53-stabilization","score":0.5195,"url":"https://openalex.org/keywords/p53-stabilization"},{"display_name":"E2F transcription factors","id":"e2f-transcription-factors","score":0.3562,"url":"https://openalex.org/keywords/e2f-transcription-factors"},{"display_name":"p53 activation","id":"p53-activation","score":0.3784,"url":"https://openalex.org/keywords/p53-activation"},{"display_name":"wild-type p53","id":"wild-type-p53","score":0.4482,"url":"https://openalex.org/keywords/wild-type-p53"},{"display_name":"p53 target genes","id":"p53-target-genes","score":0.5757,"url":"https://openalex.org/keywords/p53-target-genes"},{"display_name":"cyclin A","id":"cyclin-a","score":0.2391,"url":"https://openalex.org/keywords/cyclin-a"},{"display_name":"MDM2 inhibitors","id":"mdm2-inhibitors","score":0.5039,"url":"https://openalex.org/keywords/mdm2-inhibitors"},{"display_name":"cyclins","id":"cyclins","score":0.2454,"url":"https://openalex.org/keywords/cyclins"},{"display_name":"retinoblastoma protein phosphorylation","id":"rb-phosphorylation","score":0.2321,"url":"https://openalex.org/keywords/rb-phosphorylation"},{"display_name":"p53 family","id":"p53-family","score":0.5745,"url":"https://openalex.org/keywords/p53-family"},{"display_name":"p53 gene","id":"p53-gene","score":0.3376,"url":"https://openalex.org/keywords/p53-gene"},{"display_name":"p53-MDM2 interaction","id":"p53-mdm2-interaction","score":0.6022,"url":"https://openalex.org/keywords/p53-mdm2-interaction"},{"display_name":"Li-Fraumeni syndrome","id":"li-fraumeni-syndrome","score":0.227,"url":"https://openalex.org/keywords/li-fraumeni-syndrome"},{"display_name":"p53 reactivation","id":"p53-reactivation","score":0.6673,"url":"https://openalex.org/keywords/p53-reactivation"}],"legacy_keywords":["p53","cell cycle","MDM2","tumor suppression","cancer therapy","apoptosis","CDKs","mutation","regulation","oncogene"],"openalex_id":"https://openalex.org/T10583","source_created_date":"2024-01-23T15:27:07","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2730","url":"/topics/T10583","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10583","works_count":81502,"label":"Cancer-related Molecular Pathways","provider":"openalex","revision":"18925cbcd1ca8585","taxonomy_revision":"f050b5d4780b1289","title":"Cancer-related Molecular Pathways","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240213701978602","address_version":"morton4x16-v1","coordinates":[4,27,2730,10583],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}