{"cited_by_count":1873978,"description":"This cluster of papers represents a comprehensive exploration of advancements in prostate cancer research, covering topics such as androgen receptor signaling, genomic profiling, hormone therapy, immunotherapy, genetic mutations, clinical trials, biomarkers, and molecular biology. The papers discuss the molecular determinants of resistance to antiandrogen therapy, the impact of translocations and gene fusions on cancer causation, and the development of second-generation antiandrogens for the treatment of advanced prostate cancer.","display_name":"Prostate Cancer Treatment and Research","domain_id":"4","external_ids":{"openalex":"https://openalex.org/T10543","wikipedia":"https://en.wikipedia.org/wiki/Prostate_cancer"},"field_id":"27","id":"T10543","keywords":[{"display_name":"castration-resistant prostate cancer","id":"castration-resistant-prostate-cancer","score":0.6892,"url":"https://openalex.org/keywords/castration-resistant-prostate-cancer"},{"display_name":"androgen deprivation therapy","id":"androgen-deprivation-therapy","score":0.501,"url":"https://openalex.org/keywords/androgen-deprivation-therapy"},{"display_name":"androgen 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epithelium","id":"prostatic-epithelium","score":0.6664,"url":"https://openalex.org/keywords/prostatic-epithelium"},{"display_name":"DU145 cells","id":"du145-cells","score":0.2372,"url":"https://openalex.org/keywords/du145-cells"},{"display_name":"androgen receptor pathway inhibitors","id":"androgen-receptor-pathway-inhibitors","score":0.7663,"url":"https://openalex.org/keywords/androgen-receptor-pathway-inhibitors"},{"display_name":"TMPRSS2-ERG fusion","id":"tmprss2-erg-fusion","score":0.7261,"url":"https://openalex.org/keywords/tmprss2-erg-fusion"},{"display_name":"enzalutamide resistance","id":"enzalutamide-resistance","score":0.8872,"url":"https://openalex.org/keywords/enzalutamide-resistance"}],"legacy_keywords":["Prostate Cancer","Androgen Receptor","Genomic Profiling","Hormone Therapy","Metastatic Prostate Cancer","Immunotherapy","Genetic Mutations","Clinical Trials","Biomarkers","Molecular 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