{"cited_by_count":2609546,"description":"This cluster of papers explores the effects of stress on brain function, behavior, and cognition, with a focus on the role of cortisol, neurobiology, and the HPA axis. It covers topics such as the impact of stress on the immune system, neuroendocrine regulation, and the association between stress and disorders like depression. The research also delves into the neurobiology of resilience, hippocampal volume reduction, and the long-term consequences of prenatal stress.","display_name":"Stress Responses and Cortisol","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10529","wikipedia":"https://en.wikipedia.org/wiki/Effects_of_stress_on_brain_function_and_health"},"field_id":"28","id":"T10529","keywords":[{"display_name":"hypothalamic-pituitary-adrenal axis","id":"hypothalamic-pituitary-adrenal-axis","score":0.3547,"url":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis"},{"display_name":"corticosterone","id":"corticosterone","score":0.2237,"url":"https://openalex.org/keywords/corticosterone"},{"display_name":"chronic stress","id":"chronic-stress","score":0.2106,"url":"https://openalex.org/keywords/chronic-stress"},{"display_name":"corticotropin-releasing factor","id":"corticotropin-releasing-factor","score":0.2838,"url":"https://openalex.org/keywords/corticotropin-releasing-factor"},{"display_name":"salivary cortisol","id":"salivary-cortisol","score":0.2815,"url":"https://openalex.org/keywords/salivary-cortisol"},{"display_name":"restraint stress","id":"restraint-stress","score":0.3023,"url":"https://openalex.org/keywords/restraint-stress"},{"display_name":"stress hormones","id":"stress-hormones","score":0.2191,"url":"https://openalex.org/keywords/stress-hormones"},{"display_name":"acute stress","id":"acute-stress","score":0.2512,"url":"https://openalex.org/keywords/acute-stress"},{"display_name":"psychoneuroimmunology","id":"psychoneuroimmunology","score":0.307,"url":"https://openalex.org/keywords/psychoneuroimmunology"},{"display_name":"early life stress","id":"early-life-stress","score":0.2592,"url":"https://openalex.org/keywords/early-life-stress"},{"display_name":"dexamethasone suppression test","id":"dexamethasone-suppression-test","score":0.2357,"url":"https://openalex.org/keywords/dexamethasone-suppression-test"},{"display_name":"ACTH secretion","id":"acth-secretion","score":0.3367,"url":"https://openalex.org/keywords/acth-secretion"},{"display_name":"stress reactivity","id":"stress-reactivity","score":0.2531,"url":"https://openalex.org/keywords/stress-reactivity"},{"display_name":"stress biomarkers","id":"stress-biomarkers","score":0.2101,"url":"https://openalex.org/keywords/stress-biomarkers"},{"display_name":"Trier Social Stress Test","id":"trier-social-stress-test","score":0.4299,"url":"https://openalex.org/keywords/trier-social-stress-test"},{"display_name":"cortisol awakening response","id":"cortisol-awakening-response","score":0.526,"url":"https://openalex.org/keywords/cortisol-awakening-response"},{"display_name":"pituitary-adrenal axis","id":"pituitary-adrenal-axis","score":0.2997,"url":"https://openalex.org/keywords/pituitary-adrenal-axis"},{"display_name":"hair cortisol","id":"hair-cortisol","score":0.3503,"url":"https://openalex.org/keywords/hair-cortisol"},{"display_name":"cortisol response","id":"cortisol-response","score":0.3676,"url":"https://openalex.org/keywords/cortisol-response"},{"display_name":"diurnal cortisol rhythm","id":"diurnal-cortisol-rhythm","score":0.432,"url":"https://openalex.org/keywords/diurnal-cortisol-rhythm"},{"display_name":"stress physiology","id":"stress-physiology","score":0.2188,"url":"https://openalex.org/keywords/stress-physiology"},{"display_name":"neuroendocrine stress response","id":"neuroendocrine-stress-response","score":0.356,"url":"https://openalex.org/keywords/neuroendocrine-stress-response"},{"display_name":"neuroendocrine-immune interaction","id":"neuroendocrine-immune-interaction","score":0.3589,"url":"https://openalex.org/keywords/neuroendocrine-immune-interaction"},{"display_name":"HPA axis dysregulation","id":"hpa-axis-dysregulation","score":0.388,"url":"https://openalex.org/keywords/hpa-axis-dysregulation"},{"display_name":"neuroendocrine response","id":"neuroendocrine-response","score":0.2088,"url":"https://openalex.org/keywords/neuroendocrine-response"}],"legacy_keywords":["Stress","Brain","Cortisol","Neurobiology","HPA Axis","Immune System","Depression","Hippocampus","Psychological","Adaptation"],"openalex_id":"https://openalex.org/T10529","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2802","url":"/topics/T10529","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10529","works_count":89108,"label":"Stress Responses and Cortisol","provider":"openalex","revision":"1ea743e3a1b9a837","taxonomy_revision":"f050b5d4780b1289","title":"Stress Responses and Cortisol","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240213642977865","address_version":"morton4x16-v1","coordinates":[1,28,2802,10529],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}