{"cited_by_count":2815038,"description":"This cluster of papers explores the regulation and function of microtubules in cell division, with a focus on topics such as mitotic checkpoint, molecular motors, aneuploidy, and the role of kinesin proteins and Aurora kinases. It also delves into the implications of chromosomal instability and the potential applications for cancer therapy.","display_name":"Microtubule and mitosis dynamics","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10492","wikipedia":"https://en.wikipedia.org/wiki/Microtubule"},"field_id":"13","id":"T10492","keywords":[{"display_name":"mitosis","id":"mitosis","score":0.4284,"url":"https://openalex.org/keywords/mitosis"},{"display_name":"chromosome segregation","id":"chromosome-segregation","score":0.5206,"url":"https://openalex.org/keywords/chromosome-segregation"},{"display_name":"microtubules","id":"microtubules","score":0.28,"url":"https://openalex.org/keywords/microtubules"},{"display_name":"microtubule dynamics","id":"microtubule-dynamics","score":0.6319,"url":"https://openalex.org/keywords/microtubule-dynamics"},{"display_name":"mitotic spindle","id":"mitotic-spindle","score":0.7454,"url":"https://openalex.org/keywords/mitotic-spindle"},{"display_name":"spindle assembly checkpoint","id":"spindle-assembly-checkpoint","score":0.7223,"url":"https://openalex.org/keywords/spindle-assembly-checkpoint"},{"display_name":"cytokinesis","id":"cytokinesis","score":0.4576,"url":"https://openalex.org/keywords/cytokinesis"},{"display_name":"centrosome","id":"centrosome","score":0.5842,"url":"https://openalex.org/keywords/centrosome"},{"display_name":"microtubule assembly","id":"microtubule-polymerization","score":0.5591,"url":"https://openalex.org/keywords/microtubule-polymerization"},{"display_name":"kinetochore","id":"kinetochore","score":0.7329,"url":"https://openalex.org/keywords/kinetochore"},{"display_name":"tubulin","id":"tubulin","score":0.3653,"url":"https://openalex.org/keywords/tubulin"},{"display_name":"kinesin","id":"kinesin","score":0.595,"url":"https://openalex.org/keywords/kinesin"},{"display_name":"microtubule-associated proteins","id":"microtubule-associated-proteins","score":0.5069,"url":"https://openalex.org/keywords/microtubule-associated-proteins"},{"display_name":"molecular motors","id":"molecular-motors","score":0.2368,"url":"https://openalex.org/keywords/molecular-motors"},{"display_name":"microtubule nucleation","id":"microtubule-nucleation","score":0.8794,"url":"https://openalex.org/keywords/microtubule-nucleation"},{"display_name":"centromere","id":"centromere","score":0.2429,"url":"https://openalex.org/keywords/centromere"},{"display_name":"Aurora B kinase","id":"aurora-b-kinase","score":0.529,"url":"https://openalex.org/keywords/aurora-b-kinase"},{"display_name":"AURKA","id":"aurora-a-kinase","score":0.3413,"url":"https://openalex.org/keywords/aurora-a-kinase"},{"display_name":"dynein","id":"dynein","score":0.4908,"url":"https://openalex.org/keywords/dynein"},{"display_name":"PLK1","id":"plk1","score":0.3433,"url":"https://openalex.org/keywords/plk1"},{"display_name":"microtubule stabilization","id":"microtubule-stabilization","score":0.4349,"url":"https://openalex.org/keywords/microtubule-stabilization"},{"display_name":"microtubule motor proteins","id":"microtubule-motors","score":0.6935,"url":"https://openalex.org/keywords/microtubule-motors"},{"display_name":"mitotic arrest","id":"mitotic-arrest","score":0.4189,"url":"https://openalex.org/keywords/mitotic-arrest"},{"display_name":"anaphase","id":"anaphase","score":0.6956,"url":"https://openalex.org/keywords/anaphase"},{"display_name":"anaphase-promoting complex","id":"anaphase-promoting-complex","score":0.4776,"url":"https://openalex.org/keywords/anaphase-promoting-complex"}],"legacy_keywords":["Microtubules","Cell Division","Mitotic Checkpoint","Molecular Motors","Aneuploidy","Kinesin Proteins","Aurora Kinases","Chromosomal Instability","Spindle Assembly","Cancer Therapy"],"openalex_id":"https://openalex.org/T10492","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1307","url":"/topics/T10492","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10492","works_count":97925,"label":"Microtubule and mitosis dynamics","provider":"openalex","revision":"000972d53408ac4c","taxonomy_revision":"f050b5d4780b1289","title":"Microtubule and mitosis dynamics","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36173952024635975","address_version":"morton4x16-v1","coordinates":[1,13,1307,10492],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}