{"cited_by_count":2459117,"description":"This cluster of papers explores the neuroendocrine regulation of appetite and body weight, focusing on the roles of leptin, ghrelin, and insulin in modulating food intake and energy balance. It delves into the intricate neural circuits within the hypothalamus and their interactions with various hormonal signals to regulate feeding behavior and metabolic homeostasis.","display_name":"Regulation of Appetite and Obesity","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10489","wikipedia":"https://en.wikipedia.org/wiki/Appetite#Neuroendocrine_regulation"},"field_id":"28","id":"T10489","keywords":[{"display_name":"appetite regulation","id":"appetite-regulation","score":0.5668,"url":"https://openalex.org/keywords/appetite-regulation"},{"display_name":"ghrelin","id":"ghrelin","score":0.4117,"url":"https://openalex.org/keywords/ghrelin"},{"display_name":"food intake regulation","id":"food-intake-regulation","score":0.6009,"url":"https://openalex.org/keywords/food-intake-regulation"},{"display_name":"energy homeostasis","id":"energy-homeostasis","score":0.3609,"url":"https://openalex.org/keywords/energy-homeostasis"},{"display_name":"satiety","id":"satiety","score":0.4032,"url":"https://openalex.org/keywords/satiety"},{"display_name":"appetite","id":"appetite","score":0.243,"url":"https://openalex.org/keywords/appetite"},{"display_name":"arcuate nucleus","id":"arcuate-nucleus","score":0.364,"url":"https://openalex.org/keywords/arcuate-nucleus"},{"display_name":"hyperphagia","id":"hyperphagia","score":0.3794,"url":"https://openalex.org/keywords/hyperphagia"},{"display_name":"leptin receptor","id":"leptin-receptor","score":0.3529,"url":"https://openalex.org/keywords/leptin-receptor"},{"display_name":"body weight regulation","id":"body-weight-regulation","score":0.4794,"url":"https://openalex.org/keywords/body-weight-regulation"},{"display_name":"leptin resistance","id":"leptin-resistance","score":0.4891,"url":"https://openalex.org/keywords/leptin-resistance"},{"display_name":"ventromedial hypothalamus","id":"ventromedial-hypothalamic-nucleus","score":0.3898,"url":"https://openalex.org/keywords/ventromedial-hypothalamic-nucleus"},{"display_name":"lateral hypothalamus","id":"lateral-hypothalamus","score":0.3142,"url":"https://openalex.org/keywords/lateral-hypothalamus"},{"display_name":"food deprivation","id":"food-deprivation","score":0.2058,"url":"https://openalex.org/keywords/food-deprivation"},{"display_name":"proopiomelanocortin","id":"proopiomelanocortin","score":0.2631,"url":"https://openalex.org/keywords/proopiomelanocortin"},{"display_name":"agouti-related protein","id":"agouti-related-protein","score":0.6645,"url":"https://openalex.org/keywords/agouti-related-protein"},{"display_name":"melanocortin-4 receptor","id":"melanocortin-4-receptor","score":0.3999,"url":"https://openalex.org/keywords/melanocortin-4-receptor"},{"display_name":"peptide YY","id":"peptide-yy","score":0.3066,"url":"https://openalex.org/keywords/peptide-yy"},{"display_name":"growth hormone secretagogue receptor","id":"growth-hormone-secretagogue-receptor","score":0.449,"url":"https://openalex.org/keywords/growth-hormone-secretagogue-receptor"},{"display_name":"hypothalamic neurons","id":"hypothalamic-neurons","score":0.2128,"url":"https://openalex.org/keywords/hypothalamic-neurons"},{"display_name":"food reward","id":"food-reward","score":0.2334,"url":"https://openalex.org/keywords/food-reward"},{"display_name":"leptin signaling","id":"leptin-signaling","score":0.4572,"url":"https://openalex.org/keywords/leptin-signaling"},{"display_name":"feeding inhibition","id":"feeding-inhibition","score":0.4387,"url":"https://openalex.org/keywords/feeding-inhibition"},{"display_name":"appetitive behavior","id":"appetitive-behavior","score":0.4173,"url":"https://openalex.org/keywords/appetitive-behavior"},{"display_name":"meal size","id":"meal-size","score":0.3799,"url":"https://openalex.org/keywords/meal-size"}],"legacy_keywords":["Leptin","Ghrelin","Hypothalamus","Food Intake","Obesity","Insulin","Neural Circuits","Energy Balance","Melanocortin System","Hormonal Regulation"],"openalex_id":"https://openalex.org/T10489","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2807","url":"/topics/T10489","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10489","works_count":84424,"label":"Regulation of Appetite and Obesity","provider":"openalex","revision":"12a0064e36e7f016","taxonomy_revision":"f050b5d4780b1289","title":"Regulation of Appetite and Obesity","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36240181565498957","address_version":"morton4x16-v1","coordinates":[1,28,2807,10489],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}