{"cited_by_count":1390970,"description":"This cluster of papers focuses on the reciprocal developmental pathways for the generation of pathogenic effector TH17 cells and regulatory T cells, particularly in the context of autoimmune inflammation, interleukin-23, psoriasis, and the role of cytokines such as TGF-\u00df. It also explores the differentiation, cytokine profile, and function of human interleukin 17\u2013producing helper T cells.","display_name":"Psoriasis: Treatment and Pathogenesis","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10469","wikipedia":"https://en.wikipedia.org/wiki/TH17_cell"},"field_id":"24","id":"T10469","keywords":[{"display_name":"psoriasis","id":"psoriasis","score":0.5417,"url":"https://openalex.org/keywords/psoriasis"},{"display_name":"plaque psoriasis","id":"plaque-psoriasis","score":0.7982,"url":"https://openalex.org/keywords/plaque-psoriasis"},{"display_name":"psoriasis treatment","id":"psoriasis-treatment","score":0.8035,"url":"https://openalex.org/keywords/psoriasis-treatment"},{"display_name":"ustekinumab","id":"ustekinumab","score":0.323,"url":"https://openalex.org/keywords/ustekinumab"},{"display_name":"secukinumab","id":"secukinumab","score":0.472,"url":"https://openalex.org/keywords/secukinumab"},{"display_name":"moderate-to-severe psoriasis","id":"moderate-to-severe-psoriasis","score":0.9657,"url":"https://openalex.org/keywords/moderate-to-severe-psoriasis"},{"display_name":"psoriasis pathogenesis","id":"psoriasis-pathogenesis","score":0.9289,"url":"https://openalex.org/keywords/psoriasis-pathogenesis"},{"display_name":"PASI","id":"pasi","score":0.7164,"url":"https://openalex.org/keywords/pasi"},{"display_name":"Dermatology Life Quality Index","id":"dermatology-life-quality-index","score":0.3143,"url":"https://openalex.org/keywords/dermatology-life-quality-index"},{"display_name":"PASI score","id":"pasi-score","score":0.8218,"url":"https://openalex.org/keywords/pasi-score"},{"display_name":"acitretin","id":"acitretin","score":0.457,"url":"https://openalex.org/keywords/acitretin"},{"display_name":"pediatric psoriasis","id":"pediatric-psoriasis","score":0.879,"url":"https://openalex.org/keywords/pediatric-psoriasis"},{"display_name":"generalized pustular psoriasis","id":"generalized-pustular-psoriasis","score":0.841,"url":"https://openalex.org/keywords/generalized-pustular-psoriasis"},{"display_name":"IL-23 inhibitors","id":"il-23-inhibitors","score":0.6014,"url":"https://openalex.org/keywords/il-23-inhibitors"},{"display_name":"ixekizumab","id":"ixekizumab","score":0.6209,"url":"https://openalex.org/keywords/ixekizumab"},{"display_name":"keratinocyte proliferation","id":"keratinocyte-proliferation","score":0.2551,"url":"https://openalex.org/keywords/keratinocyte-proliferation"},{"display_name":"Psoriasis Area and Severity Index","id":"psoriasis-area-and-severity-index","score":0.8158,"url":"https://openalex.org/keywords/psoriasis-area-and-severity-index"},{"display_name":"nail psoriasis","id":"nail-psoriasis","score":0.5368,"url":"https://openalex.org/keywords/nail-psoriasis"},{"display_name":"IL-17 inhibitors","id":"il-17-inhibitors","score":0.4744,"url":"https://openalex.org/keywords/il-17-inhibitors"},{"display_name":"calcipotriol","id":"calcipotriol","score":0.5067,"url":"https://openalex.org/keywords/calcipotriol"},{"display_name":"psoriasis severity","id":"psoriasis-severity","score":0.7924,"url":"https://openalex.org/keywords/psoriasis-severity"},{"display_name":"pustular psoriasis","id":"pustular-psoriasis","score":0.627,"url":"https://openalex.org/keywords/pustular-psoriasis"},{"display_name":"apremilast","id":"apremilast","score":0.4148,"url":"https://openalex.org/keywords/apremilast"},{"display_name":"guselkumab","id":"guselkumab","score":0.5246,"url":"https://openalex.org/keywords/guselkumab"},{"display_name":"scalp psoriasis","id":"scalp-psoriasis","score":0.7605,"url":"https://openalex.org/keywords/scalp-psoriasis"}],"legacy_keywords":["IL-17","TH17 Cells","Interleukin-23","Autoimmune Inflammation","Psoriasis","TGF-\u00df","Regulatory T Cells","Inflammatory Cytokines","Pathogenic Effector Cells","Immune System"],"openalex_id":"https://openalex.org/T10469","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"2403","url":"/topics/T10469","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10469","works_count":88761,"label":"Psoriasis: Treatment and Pathogenesis","provider":"openalex","revision":"a3e89a110a506d2d","taxonomy_revision":"f050b5d4780b1289","title":"Psoriasis: Treatment and Pathogenesis","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36239922792900685","address_version":"morton4x16-v1","coordinates":[1,24,2403,10469],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}