{"cited_by_count":2837659,"description":"This cluster of papers explores the molecular mechanisms underlying muscle regeneration, satellite cell function, myostatin regulation, ubiquitin ligases, and the role of various signaling pathways such as IGF-1/PI3K/Akt in preventing skeletal muscle atrophy. It also delves into the interaction between inflammatory processes and muscle injury, as well as the involvement of dystrophin in muscle function and disease. The research encompasses a wide range of topics related to muscle biology and potential therapeutic targets for muscle-related disorders.","display_name":"Muscle Physiology and Disorders","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10441","wikipedia":"https://en.wikipedia.org/wiki/Muscle_regeneration"},"field_id":"13","id":"T10441","keywords":[{"display_name":"Duchenne muscular dystrophy","id":"duchenne-muscular-dystrophy","score":0.5547,"url":"https://openalex.org/keywords/duchenne-muscular-dystrophy"},{"display_name":"myogenesis","id":"myogenesis","score":0.4463,"url":"https://openalex.org/keywords/myogenesis"},{"display_name":"muscle atrophy","id":"muscle-atrophy","score":0.3228,"url":"https://openalex.org/keywords/muscle-atrophy"},{"display_name":"muscle regeneration","id":"muscle-regeneration","score":0.6284,"url":"https://openalex.org/keywords/muscle-regeneration"},{"display_name":"muscular dystrophy","id":"muscular-dystrophy","score":0.4954,"url":"https://openalex.org/keywords/muscular-dystrophy"},{"display_name":"satellite cells","id":"satellite-cells","score":0.637,"url":"https://openalex.org/keywords/satellite-cells"},{"display_name":"dystrophin","id":"dystrophin","score":0.694,"url":"https://openalex.org/keywords/dystrophin"},{"display_name":"soleus muscle","id":"soleus-muscle","score":0.245,"url":"https://openalex.org/keywords/soleus-muscle"},{"display_name":"myopathy","id":"myopathy","score":0.2499,"url":"https://openalex.org/keywords/myopathy"},{"display_name":"mdx mice","id":"mdx-mice","score":0.752,"url":"https://openalex.org/keywords/mdx-mice"},{"display_name":"skeletal muscle atrophy","id":"skeletal-muscle-atrophy","score":0.5213,"url":"https://openalex.org/keywords/skeletal-muscle-atrophy"},{"display_name":"skeletal muscle regeneration","id":"skeletal-muscle-regeneration","score":0.6737,"url":"https://openalex.org/keywords/skeletal-muscle-regeneration"},{"display_name":"MyoD","id":"myod","score":0.4963,"url":"https://openalex.org/keywords/myod"},{"display_name":"Becker muscular dystrophy","id":"becker-muscular-dystrophy","score":0.6667,"url":"https://openalex.org/keywords/becker-muscular-dystrophy"},{"display_name":"myostatin","id":"myostatin","score":0.4108,"url":"https://openalex.org/keywords/myostatin"},{"display_name":"muscle fiber type","id":"muscle-fiber-type","score":0.2951,"url":"https://openalex.org/keywords/muscle-fiber-type"},{"display_name":"muscle hypertrophy","id":"muscle-hypertrophy","score":0.2108,"url":"https://openalex.org/keywords/muscle-hypertrophy"},{"display_name":"C2C12 myoblasts","id":"c2c12-myoblasts","score":0.3424,"url":"https://openalex.org/keywords/c2c12-myoblasts"},{"display_name":"muscle biopsy","id":"muscle-biopsy","score":0.2215,"url":"https://openalex.org/keywords/muscle-biopsy"},{"display_name":"denervation","id":"denervation","score":0.2188,"url":"https://openalex.org/keywords/denervation"},{"display_name":"dystrophin gene","id":"dmd-gene","score":0.7025,"url":"https://openalex.org/keywords/dmd-gene"},{"display_name":"myogenin","id":"myogenin","score":0.5393,"url":"https://openalex.org/keywords/myogenin"},{"display_name":"muscle stem cells","id":"muscle-stem-cells","score":0.7588,"url":"https://openalex.org/keywords/muscle-stem-cells"},{"display_name":"myoblasts","id":"myoblasts","score":0.3768,"url":"https://openalex.org/keywords/myoblasts"},{"display_name":"facioscapulohumeral muscular dystrophy","id":"facioscapulohumeral-muscular-dystrophy","score":0.6266,"url":"https://openalex.org/keywords/facioscapulohumeral-muscular-dystrophy"}],"legacy_keywords":["Muscle Regeneration","Skeletal Muscle Atrophy","Satellite Cells","Myostatin","Ubiquitin Ligases","Stem Cells","FoxO Transcription Factors","Dystrophin","IGF-1/PI3K/Akt Pathway","Inflammatory Processes"],"openalex_id":"https://openalex.org/T10441","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T10441","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10441","works_count":138546,"label":"Muscle Physiology and Disorders","provider":"openalex","revision":"4b7c5dfb0104a63e","taxonomy_revision":"f050b5d4780b1289","title":"Muscle Physiology and Disorders","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36173952019636747","address_version":"morton4x16-v1","coordinates":[1,13,1312,10441],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}