{"cited_by_count":2688367,"description":"This cluster of papers focuses on the structure, topology, and biological functions of G-quadruplex DNA, particularly in relation to telomeres, therapeutic targets, and antisense oligonucleotides. It explores the potential of G-quadruplexes as targets for cancer therapy and drug design, as well as their role in genomic stability and molecular recognition.","display_name":"DNA and Nucleic Acid Chemistry","domain_id":"1","external_ids":{"openalex":"https://openalex.org/T10432","wikipedia":"https://en.wikipedia.org/wiki/G-quadruplex"},"field_id":"13","id":"T10432","keywords":[{"display_name":"G-quadruplex","id":"g-quadruplex","score":0.6585,"url":"https://openalex.org/keywords/g-quadruplex"},{"display_name":"oligonucleotide synthesis","id":"oligonucleotide-synthesis","score":0.7275,"url":"https://openalex.org/keywords/oligonucleotide-synthesis"},{"display_name":"DNA conformation","id":"dna-conformation","score":0.5396,"url":"https://openalex.org/keywords/dna-conformation"},{"display_name":"nucleoside synthesis","id":"nucleoside-synthesis","score":0.3033,"url":"https://openalex.org/keywords/nucleoside-synthesis"},{"display_name":"DNA structure","id":"dna-structure","score":0.4205,"url":"https://openalex.org/keywords/dna-structure"},{"display_name":"double-stranded DNA","id":"double-stranded-dna","score":0.2986,"url":"https://openalex.org/keywords/double-stranded-dna"},{"display_name":"DNA intercalation","id":"dna-intercalation","score":0.2114,"url":"https://openalex.org/keywords/dna-intercalation"},{"display_name":"B-DNA","id":"b-dna","score":0.6514,"url":"https://openalex.org/keywords/b-dna"},{"display_name":"DNA secondary structure","id":"dna-secondary-structure","score":0.5267,"url":"https://openalex.org/keywords/dna-secondary-structure"},{"display_name":"peptide nucleic acid","id":"peptide-nucleic-acid","score":0.3649,"url":"https://openalex.org/keywords/peptide-nucleic-acid"},{"display_name":"Z-DNA","id":"z-dna","score":0.6748,"url":"https://openalex.org/keywords/z-dna"},{"display_name":"Watson-Crick base pairing","id":"watson-crick-base-pairing","score":0.5329,"url":"https://openalex.org/keywords/watson-crick-base-pairing"},{"display_name":"base stacking","id":"base-stacking","score":0.5719,"url":"https://openalex.org/keywords/base-stacking"},{"display_name":"triplex DNA","id":"triplex-dna","score":0.724,"url":"https://openalex.org/keywords/triplex-dna"},{"display_name":"nucleic acid structure","id":"nucleic-acid-structure","score":0.5031,"url":"https://openalex.org/keywords/nucleic-acid-structure"},{"display_name":"oligonucleotides","id":"oligonucleotides","score":0.2962,"url":"https://openalex.org/keywords/oligonucleotides"},{"display_name":"DNA supercoiling","id":"dna-supercoiling","score":0.2288,"url":"https://openalex.org/keywords/dna-supercoiling"},{"display_name":"DNA double helix","id":"dna-double-helix","score":0.2705,"url":"https://openalex.org/keywords/dna-double-helix"},{"display_name":"oligodeoxynucleotides","id":"oligodeoxynucleotides","score":0.5495,"url":"https://openalex.org/keywords/oligodeoxynucleotides"},{"display_name":"DNA topology","id":"dna-topology","score":0.2465,"url":"https://openalex.org/keywords/dna-topology"},{"display_name":"DNA denaturation","id":"dna-denaturation","score":0.3891,"url":"https://openalex.org/keywords/dna-denaturation"},{"display_name":"modified nucleosides","id":"modified-nucleosides","score":0.4241,"url":"https://openalex.org/keywords/modified-nucleosides"},{"display_name":"telomeric DNA","id":"telomeric-dna","score":0.5263,"url":"https://openalex.org/keywords/telomeric-dna"},{"display_name":"DNA conformational change","id":"dna-conformational-change","score":0.4245,"url":"https://openalex.org/keywords/dna-conformational-change"},{"display_name":"base pairing","id":"base-pairing","score":0.3512,"url":"https://openalex.org/keywords/base-pairing"}],"legacy_keywords":["G-Quadruplexes","DNA Structure","Nucleic Acids","Therapeutic Targets","Telomeres","Antisense Oligonucleotides","Biological Functions","Molecular Recognition","Drug Design","Genomic Stability"],"openalex_id":"https://openalex.org/T10432","source_created_date":"2024-01-23T15:27:06","source_updated_date":"2026-10-17T03:02:00","subfield_id":"1312","url":"/topics/T10432","works_api_url":"https://api.openalex.org/works?filter=topics.id:T10432","works_count":116769,"label":"DNA and Nucleic Acid Chemistry","provider":"openalex","revision":"42a9ca23b875074f","taxonomy_revision":"f050b5d4780b1289","title":"DNA and Nucleic Acid Chemistry","kind":"topic-directory","aeo_cohort":"topic-directory","catalogue_revision":"f050b5d4780b1289","numeric_address":"36173952019603971","address_version":"morton4x16-v1","coordinates":[1,13,1312,10432],"answer_status":"Directory metadata; local answer requires separate source review","truth_status":"Subject descriptor, not a factual answer or a demonstrated knowledge gap","reviewed_answer":null}